Dissociation of the effects of digitalis on myocardial potassium flux and contractility

Scherlag, B J; Rh, Helfant; Ricciutti, MA; Damato, AN

doi:10.1152/ajplegacy.1968.215.5.1288

Cited by 16 publications

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“…The results of this study would suggest that the effect of DPH and K on the positive inotropic response of ouabain should be examined under conditions in which only positive inotropy and not arrhythmia is present. Apparent increases in ouabain inotropy due to DPH and K measured near the time of ouabain toxicity (see Scherlag et al, 1968;Williams et a!., 1966) may be misleading if the enhancement in inotropy seen in the presence of the antiarrhythmic agents is thought to occur at all time periods of drug interaction.…”

Section: Discussionmentioning

confidence: 99%

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

Baskin

Dutta

Marks

1973

British J Pharmacology

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Summary1. Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guineapig isolated heart. 2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.

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Section: Discussionmentioning

confidence: 99%

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

Baskin

Dutta

Marks

1973

British J Pharmacology

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Influence of the membrane stabilizer diphenylhydantion on potassium and sodium movements in skeletal muscle

1975

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The membrane stabilizer diphenylhydantoin (DPH) did not alter the net content of Na, K, Ca or Mg in frog sartorius muscle freshly incubated or actively transporting Na and K following Na-loading and K-depletion. Resting influx of K from normal Ringer was significantly reduced by DPH, and this inhibition occurred in the ouabain-insensitive K-uptake. Inhibition of K-influx by DPH was overcome when [K]0 was raised to 10 mM, and Rb-influx was not sensitive to the inhibitor in 2.5 mM Rb-Ringer. Efflux of tracer K was reduced by DPH in the presence and absence of ouabain. Exchange of muscle Na was not affected under conditions in which K-exchange was significantly reduced, but DPH appeared to cause increased net loss of Na from muscles washed in Na-free medium. The inhibition of DPH of resting K-exchange was not sensitive to wide variations in [Na]0 or in [Ca]0. The results suggest that the effect of DPH on frog skeletal muscle in normal ionic environment is to reduce the resting, passive component of K-exchange across the fibre membrane. This effect is discussed in relation to the membrane stabilizing actions of diphenylhydantoin.

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Influence of diphenylhydantoin on the inotropic and potassium-losing effects of acetyl strophanthidin

Miller

Gilmore

1970

American Heart Journal

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Dissociation of the effects of digitalis on myocardial potassium flux and contractility

Cited by 16 publications

References 0 publications

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart

Influence of the membrane stabilizer diphenylhydantion on potassium and sodium movements in skeletal muscle

Influence of diphenylhydantoin on the inotropic and potassium-losing effects of acetyl strophanthidin

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