Dissociation of serotonergic regulation of anxiety and ethanol self-administration

Buczek, Yvona; Dm, Tomkins; Ga, Higgins; Em, Sellers

doi:10.1097/00008877-199408000-00008

Cited by 22 publications

(9 citation statements)

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“…All injections were made 30 min prior to training. Previous data showed that the doses of DZP (2 mg/kg) and PTZ (15 mg/kg) used in the present study show anxiolytic and anxiogenic effects, respectively, both in the conventional elevated plus-maze (File et al, 1987;Guimarães et al, 1990;Taukulis and Goggin, 1990;Almeida et al, 1991;Buczek et al, 1994) and in the aversive version of the discriminative task in this apparatus (unpublished data). It also should be noted that the PTZ dose used here is much lower than the usual dose range used in convulsion studies (50 mg/kg or more- Lian et al, 2006;Obay et al, 2007;Palencia et al, 2007;Mao et al, 2009).…”

Section: Drugssupporting

confidence: 56%

A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior

Godinho

Ribeiro

Fernandes

et al. 2009

Journal of Neuroscience Methods

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Section: Drugssupporting

confidence: 56%

A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior

Godinho

Ribeiro

Fernandes

et al. 2009

Journal of Neuroscience Methods

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“…However, responding maintained by water occurred at very low rates, and was chosen less than ethanol. Others have shown similar results using free access to ethanol and water, but again water intake was substantially lower than ethanol intake (Buczek et al ., ). In the present study, both DOI and mCPP appeared to selectively reduce ethanol‐ versus food‐maintained responding under the multiple schedule.…”

Section: Discussionmentioning

confidence: 97%

Drug effects on multiple and concurrent schedules of ethanol‐ and food‐maintained behaviour: context‐dependent selectivity

Ginsburg

Lamb

2014

British J Pharmacology

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BACKGROUND AND PURPOSEDrugs that more potently or effectively reduce ethanol-maintained behaviour versus an alternative are considered selective and are considered promising pharmacotherapies for alcoholism. Such results are often obtained using separate groups or multiple schedules where ethanol and the alternative are available alone or sequentially. Recently, we observed that when ethanol and food were available sequentially under a multiple schedule, fluvoxamine and varenicline were selective; yet this selectivity disappeared when ethanol and food were concurrently available. EXPERIMENTAL APPROACHWe examined the generality of these findings by comparing doses of several drugs required to decrease ethanol-and food-maintained responding under a multiple schedule and under a concurrent schedule. Effects were determined for chlordiazepoxide, 2,5-dimethoxy-4-iodoamphetamine (DOI), meta-chlorophenylpiperazine (mCPP), morphine, naltrexone and d-amphetamine. KEY RESULTSUnder the multiple schedule, ED50 values for decreases in ethanol-maintained responding were significantly different and lower than ED50s for decreases in food-maintained responding (demonstrating selectivity) for each drug except for chlordiazepoxide (which was equipotent) and naltrexone (which did not affect responding). However, this selectivity vanished or even inverted under the concurrent schedule, such that ED50 values for decreasing ethanol-and food-maintained responding were not different (or, following DOI, the ED50 for food-maintained responding was lower than for ethanol-maintained responding). CONCLUSIONS AND IMPLICATIONSResults are consistent with those seen following fluvoxamine and varenicline administration, and suggest that selectivity is assay-dependent. These results indicate the need for careful interpretation of selective drug effects, especially when obtained in situations where ethanol or the alternative is the only programmed reinforcement available.Abbreviations 5-HT, 5-hydroxytryptamine; DOI, 2,5-dimethoxy-4-iodoamphetamine; IQR, interquartile range; mCPP, meta-chlorophenylpiperazine

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“…Previously, we have used m-chlorophenylpiperazine (mCPP), a mixed 5-HT receptor agonist, to explore how the serotonergic regulation of anxiety behavior correlates with that of voluntary ETOH consumption in rats. 6 Our results indicate a dissociation between the role played by the serotonergic system in the regulation of anxiety and ETOH drinking behavior. 6 The GABAergic system is another neurotransmitter system that could possibly underlie a common link between stress and excessive alcohol use.…”

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confidence: 68%

“…6 Our results indicate a dissociation between the role played by the serotonergic system in the regulation of anxiety and ETOH drinking behavior. 6 The GABAergic system is another neurotransmitter system that could possibly underlie a common link between stress and excessive alcohol use. GABAergic mechanisms have been linked to pathophysiology of stress-related mood disorders, such as anxiety and d e p r e~s i o n ,~-~ and benzodiazepines that act at the GABA receptor complex have been very effective as anxiolytic agents."…”

mentioning

confidence: 68%

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Effect of Pentylenetetrazole on Ethanol Intake, Ethanol Kinetics, and Social Behavior in Male Wistar Rats

Buczek

Lê

Sellers

et al. 1998

Alcoholism Clin & Exp Res

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Stress and anxiety are often implicated in excessive alcohol use. The nature of this interaction, however, is not understood. The aim of this study was to examine the effect of the anxiogenic agent, pentylenetetrazole (PTZ), on the acquisition and maintenance of ethanol drinking behavior in male Wistar rats. In rats maintained on a limited access procedure, with a choice between a 12% w/v ethanol (ETOH) solution and water available for 30 min each day, acute PTZ administration (1.5 to 15.0 mg/kg) did not modify ETOH intake. Chronic PTZ administration elicited a significant suppression in ETOH intake; however, this effect developed gradually over time. During the acquisition phase, chronic PTZ treatment also suppressed ETOH consumption. Chronic, but not acute, treatment with PTZ seemed to enhance water consumption. To assess whether the effect of PTZ on ETOH intake was due to either alterations in ETOH kinetics or behavior, blood ETOH levels and social interaction behaviour were examined. PTZ (15.0 mg/kg) produced a significant suppression in social interaction behavior, although tolerance developed to this effect on chronic PTZ administration. Both acute and chronic PTZ treatment (15 mg/kg) resulted in lower blood ETOH levels achieved after administration of 1.0 g/kg po of ETOH. Because the anxiogenic effect of PTZ was not maintained on repeated administration, yet the suppression of ETOH intake was only observed after chronic treatment, this suggests a dissociation between the processes regulating these behaviors.

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Dissociation of serotonergic regulation of anxiety and ethanol self-administration

Cited by 22 publications

References 0 publications

A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior

A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior

Drug effects on multiple and concurrent schedules of ethanol‐ and food‐maintained behaviour: context‐dependent selectivity

Effect of Pentylenetetrazole on Ethanol Intake, Ethanol Kinetics, and Social Behavior in Male Wistar Rats

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