Dissociation of malondialdehyde mutagenicity in Salmonella typhimurium from its ability to induce interstrand DNA cross-links

Basu, Ashis K.; Marnett, Lawrence J.; Romano, Louis J.

doi:10.1016/0027-5107(84)90121-0

Cited by 50 publications

(29 citation statements)

References 17 publications

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“…MDA-induced DNA-ICLs are known to exist although they were reported to be formed only at acidic pH (55). We were able to detect DNA ICLs in MDA-modified plasmid and short duplex oligonucleotides under reaction conditions identical to those used for the mutation assay (Fig.…”

Section: Discussionmentioning

confidence: 83%

Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

Niedernhofer

Daniels

Rouzer

et al. 2003

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 83%

Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

Niedernhofer

Daniels

Rouzer

et al. 2003

Journal of Biological Chemistry

Self Cite

481

324

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“…Some carcinogens found in cigarette smoke, such as PAHs, N-nitrosamines, and dioxins require enzymatic activation to be toxic. In contrast, reactive carbonyl compounds analyzed in the present study can be directly cross-linked to proteins and bind covalently to nucleic acids (Lam et al, 1986;Matsufuji and Shibamoto, 2004) and consequently cause biological complications, including carcinogenesis (Basu et al, 1984;Nair et al, 1986). Therefore, it is important to determine the amounts of reactive carbonyl compounds to which people are exposed to assess the further health risks associated with cigarette smoke.…”

Section: Discussionmentioning

confidence: 86%

Determination of toxic carbonyl compounds in cigarette smoke

2006

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Toxic carbonyl compounds, including formaldehyde, malonaldehyde, and glyoxal, formed in mainstream cigarette smoke were quantified by derivatization-solid phase extraction-gas chromatography methods. Cigarette smoke from 14 commercial brands and one reference (2R1F) was drawn into a separatory funnel containing aqueous phosphate-buffered saline. Reactive carbonyl compounds trapped in the buffer solution were derivatized into stable nitrogen containing compounds (pyrazoles for -dicarbonyl and , -unsaturated aldehyde; quinoxalines for -dicarbonyls; and thiazolidines for alkanals). After derivatives were recovered using C 18 solid phase extraction cartridges, they were analyzed quantitatively by a gas chromatograph with a nitrogen phosphorus detector. The total carbonyl compounds recovered from regular size cigarettes ranged from 1.92 mg/cigarette À1 to 3.14 mg/cigarette À1 . The total carbonyl compounds recovered from a reference cigarette and a king size cigarette were 3.23 mg/cigarette À1 and 3.39 mg/cigarette À1 , respectively. The general decreasing order of the carbonyl compounds yielded was acetaldehyde (1110-2101 g/cigarette À1 ) > diacetyl (301-433 g/cigarette À1 ), acrolein (238-468 g/cigarette À1 ) > formaldehyde (87.0-243 g/cigarette À1 ), propanal (87.0-176 g/cigarette À1 ) > malonaldehyde (18.9-36.0 g/cigarette À1 ), methylglyoxal (13.4-59.6 g/cigarette À1 ) > glyoxal (1.93-6.98 g/cigarette À1 ).

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“…cancer initiating or promoting properties (Fischer et al, 1983). In vitro experiments have shown that MA can bind to DNA bases, as well as form DNAinterstrand and DNA-protein crosslinks (Chio and Tappel, 1969;Yonei and Furui, 1981;Basu et al, 1984;Nair et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Production of Malonaldehyde From Squalene, a Major Skin Surface Lipid, During Uv‐irradiation

Dennis

Shibamoto

1989

Photochem & Photobiology

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Malonaldehyde (MA), a product of lipid peroxidation, is known to have a number of toxicological effects. Among skin surface components, squalene has been suggested as a significant source of MA following UV exposure. Irradiation of squalene coated on the inside surface of glass tubes served as a simple model to examine skin surface photochemistry. Malonaldehyde produced during UV-irradiation was reacted with methyl hydrazine to form N-methylpyrazole, which was then measured by gas chromatographic analysis. Ultraviolet A-irradiation produced low levels of MA from squalene, with a maximum of 1.0 nmol MA/mumol squalene near 6 h. Malonaldehyde production varied with the energy of irradiation, with levels of 176 nmol/mg squalene and 9 nmol/mg squalene produced after 3 h of irradiation with UVB and UVA, respectively. The thiobarbituric acid (TBA) assay for lipid peroxidation showed large overestimations of MA levels under all irradiation conditions tested. The TBA assay predicted the highest levels of MA with UVC but we did not detect any MA with our assay.

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Dissociation of malondialdehyde mutagenicity in Salmonella typhimurium from its ability to induce interstrand DNA cross-links

Cited by 50 publications

References 17 publications

Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

Determination of toxic carbonyl compounds in cigarette smoke

Production of Malonaldehyde From Squalene, a Major Skin Surface Lipid, During Uv‐irradiation

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