Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats

Miyagawa, Hidekazu; Hasegawa, Masaya; Fukuta, Takanori; Amano, Minoru; Yamada, Kiyofumi; Nabeshima, Toshitaka

doi:10.1016/s0166-4328(97)00105-8

Cited by 73 publications

(54 citation statements)

References 43 publications

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“…They used an object recognition memory task and an olfactory discrimination task, in addition to a spatial task (radial water maze), to examine the relationships between age-related sensorimotor impairments (beam walking, open field and tightrope) and cognitive decline. Confirming previous findings in rodents (Gage et al 1989;Gallagher and Burwell 1989;Miyagawa et al 1998;Rapp et al 1987), they failed to find an association between sensorimotor performance and spatial task performance. In contrast, sensorimotor impairment was related to performance in the non-spatial tasks (object recognition memory and olfactory discrimination).…”

Section: Effects Of Age and Sex On Cognitive Function And Motor Speedsupporting

confidence: 83%

“…In sharp contrast with these findings in humans, several studies using rodent models have suggested that age-related deficits in learning and memory are independent of the motor deficits that develop with age (Gage et al 1989;Gallagher and Burwell 1989;Miyagawa et al 1998;Rapp et al 1987) but see Chen et al (2004). The source of these discrepancies between the human and rodent literature is unclear but may be related to differences in the assessment of motor function between the two species, with human motor function typically measured by some aspects of manual ability (finger tapping, mirror tracing, pegboard tests), while motor function is typically assessed through gross locomotor skills in rodents.…”

Section: Introductionmentioning

confidence: 84%

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Relationships among cognitive function, fine motor speed and age in the rhesus monkey

Lacreuse

Espinosa

Herndon

2006

AGE

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Declines in fine motor skills and cognitive function are well known features of human aging. Yet, the relationship between age-related impairments in motor and cognitive function remains unclear. Rhesus monkeys, like humans, show marked decline in cognitive and fine motor function with age and are excellent models to investigate potential interactions between age-related declines in cognitive and motor functioning. We investigated the relationships among cognition, motor function and age in 30 male and female rhesus monkeys, 5-28 years of age, tested on a battery of cognitive tasks [acquisition of the delayed non-matching-to-sample (DNMS), DNMS-120s, DNMS-600s, acquisition of delayed recognition span test (DRST), spatial-DRST and object-DRST] and a fine motor task (Lifesaver test). Global cognitive ability, as assessed by the cognitive performance index (CPI), was impaired with age in both sexes, while age-related motor slowing was found only in males. After age was controlled for, half the variance in CPI was predicted by motor speed, with better cognitive ability associated with slower motor skills. Analyses at the level of each cognitive task revealed that motor speed and age predicted the rate of acquisition of the DNMS. This relationship was robust in males and absent in females. Motor speed was not a significant predictor of any other cognitive variable. We conclude that the relationship between cognition and motor function (1) may be limited to non-spatial tasks; (2) exists independently of age; (3) may reflect different contributions of the fronto-striatal system; (4) may be particularly evident in males.

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Section: Effects Of Age and Sex On Cognitive Function And Motor Speedsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 84%

Relationships among cognitive function, fine motor speed and age in the rhesus monkey

Lacreuse

Espinosa

Herndon

2006

AGE

View full text Add to dashboard Cite

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“…Indeed, learning ability correlates with behavior in conditioned fear models (29). However, neither the elevated plus maze nor our punished drinking procedure relies on conditioning, and it has previously been demonstrated that learning and memory deficits per se, such as observed during aging (30) or following treatment with amnestic drugs, such as the noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MK-801 or the muscarinic cholinergic antagonist scopolamine (31), are not sufficient to produce anxiolytic-like behavior in this type of model. Based on this dissociation, we believe it unlikely that the anti-stress effects observed in NPY-tg subjects might be accounted for by effects on learning and memory.…”

Section: Discussionmentioning

confidence: 93%

Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression

Thorsell

Michalkiewicz

Dumont

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

284

192

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Exogenous neuropeptide Y (NPY) reduces experimental anxiety in a wide range of animal models. The generation of an NPYtransgenic rat has provided a unique model to examine the role of endogenous NPY in control of stress and anxiety-related behaviors using paradigms previously used by pharmacological studies. Locomotor activity and baseline behavior on the elevated plus maze were normal in transgenic subjects. Two robust phenotypic traits were observed. (i) Transgenic subjects showed a markedly attenuated sensitivity to behavioral consequences of stress, in that they were insensitive to the normal anxiogenic-like effect of restraint stress on the elevated plus maze and displayed absent fear suppression of behavior in a punished drinking test. (ii) A selective impairment of spatial memory acquisition was found in the Morris water maze. Control experiments suggest these traits to be independent. These phenotypic traits were accompanied by an overexpression of prepro-NPY mRNA and NPY peptide and decreased NPY-Y1 binding within the hippocampus, a brain structure implicated both in memory processing and stress responses. Data obtained using this unique model support and extend a previously postulated anti-stress action of NPY and provide novel evidence for a role of NPY in learning and memory.anxiety ͉ amygdala N europeptide Y (NPY) (1) is highly expressed in the mammalian brain. Its pharmacological administration into the central nervous system reduces experimental anxiety in a wide range of animal models (2-5), but its involvement in memory function is less clear. NPY receptors cloned to date all belong to the superfamily of G protein-coupled receptors but differ in their ligand affinity profiles. The NPY-Y1 receptor (6-8) requires the intact NPY sequence for recognition and activation, and seems to be the subtype mediating anti-anxiety actions of NPY (3-5, 9, 10). The Y2 receptor subtype is also activated by C-terminal fragments of NPY, such as NPY 13-36 (11). The highest number of NPY-binding sites, predominantly of the Y2 subtype, is found within the hippocampus. Activation of Y2 receptors within this structure has been shown to suppress hippocampal glutamatergic transmission through presynaptic mechanisms (12, 13), but the behavioral consequences of Y2 signaling in this area are unclear.In agreement with anti-stress effects observed following central administration of NPY, a role for endogenous NPY in control of stress and anxiety-related behaviors is suggested by several findings. Acute physical restraint, which promotes experimental anxiety (14), suppresses NPY mRNA and peptide levels within the amygdala and cortex. In contrast, repeated exposure to the same stressor once daily for 10 days leads to a complete behavioral and endocrine habituation, accompanied by an up-regulation of amygdala NPY expression (15). We have therefore proposed that an up-regulation of NPY expression may contribute to the behavioral adaptation to stress. This extends a hypothesis that NPY may act to ''buffer'' behavioral effects of st...

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“…Behavioral responses of animals to treatment was assessed in several behavioral tests in the following order: assessment of the degree of anxiety in the elevated plus maze, observation of locomotor exploratory activity in an open field, and spatial memory task in the Morris water maze [28,29]. Each test was performed once for each animal.…”

Section: Behavioral Testingmentioning

confidence: 99%

Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats

Stefanova

Фурсова

Kolosova

2010

JAD

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Abstract. Mitochondrial dysfunction is involved in aging and in neurodegenerative diseases and, therefore, pharmacological agents that alleviate mitochondrial dysfunction are expected to have neuroprotective effects. Promising in this respect is mitochondrial-targeted antioxidant plastoquinonyl-decyl-triphenylphosphonium (SkQ1). We investigated the effects of SkQ1 (250 nmol SkQ1/kg × day with food) on behavior in the elevated plus-maze (EPM) and open field (OF) and on spatial memory in a Morris water maze (MWM) in middle-aged (12 mo) Wistar and senescence-accelerated OXYS rats. Given that changes in the behavior of OXYS rats may be associated with visual impairment, the condition of the retina and the lens was evaluated by ophthalmoscopy. 14-month-old as well as 3-month-old OXYS rats had considerably reduced activities in OF, increased anxiety in EPM, and manifested impaired learning abilities in the MWM in comparison with Wistar rats. SkQ1-treated rats of both strains displayed significantly higher locomotor and exploratory activity in the OF and less anxiety in the EPM compared to age-matched controls. SkQ1 significantly improved visual ability of the rats reducing the severity of the developed signs of retinopathy and cataract but had no impact on OXYS rat's spatial memory in the MWM. SkQ1-treated Wistar rats exhibited slower learning in the MWM task comparison to the control group. Thus, SkQ1 had beneficial effects on locomotor and exploratory functions of the rat brain. Nevertheless, SkQ1 did not alter learning performance in the MWM in OXYS rats and slightly reduced it in the Wistar strain, which may be associated with differences in redox homeostasis.

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Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats

Cited by 73 publications

References 43 publications

Relationships among cognitive function, fine motor speed and age in the rhesus monkey

Relationships among cognitive function, fine motor speed and age in the rhesus monkey

Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression

Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats

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