Dissociation of decision making under ambiguity and decision making under risk: A neurocognitive endophenotype candidate for obsessive–compulsive disorder

Zhang, Long; Dong, Yi; Ji, Yifu; Zhu, Chunyan; Yu, Fang; Ma, Hu; Chen, Xingui; Wang, Kai

doi:10.1016/j.pnpbp.2014.09.005

Cited by 51 publications

(59 citation statements)

References 71 publications

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“…This is consistent with mixed results reported by prior studies of uncertainty intolerance in OCD that used various paradigms, including those that allow feedback evaluation and learning (Nielen et al, 2002; Lawrence et al, 2006; Da Rocha et al, 2011; Admon et al, 2012; Zhang et al, 2015). For instance, Sohn et al (2014) utilized the Balloon Analogue Risk Task and found lower levels of risk taking in OCD relative to healthy individuals.…”

Section: Discussionsupporting

confidence: 91%

“…For instance, Sohn et al (2014) utilized the Balloon Analogue Risk Task and found lower levels of risk taking in OCD relative to healthy individuals. Several studies have found enhanced ambiguity but not risk aversion in OCD (Starcke et al, 2010; Pushkarskaya et al, 2015; Zhang et al, 2015). Sip et al (2016), using a gambling task without feedback, under different framing (gains versus losses) found that individuals with OCD are more risk averse when facing losses that are framed as gains, compared to explicit losses.…”

Section: Discussionmentioning

confidence: 98%

“…Studies of value-based making have also employed a variety of behavioral tasks, but have produced less consistent results. For instance, using the Iowa Gambling task (Bechara et al, 1994), some studies found that individuals with OCD perform worse than controls (Da Rocha et al, 2011; Zhang et al, 2015) while others studies found no between-group differences (Nielen et al, 2002; Lawrence et al, 2006). On the Cambridge Gambling Task (Manes et al, 2002), Dittrich and Johansen (2013) found that individuals with OCD are less likely to choose an objectively more valuable option and take longer to decide, but Chamberlain et al (2007) found no between-group differences.…”

Section: Introductionmentioning

confidence: 99%

“…On the Cambridge Gambling Task (Manes et al, 2002), Dittrich and Johansen (2013) found that individuals with OCD are less likely to choose an objectively more valuable option and take longer to decide, but Chamberlain et al (2007) found no between-group differences. On the Game of Dice task, some studies (Brand et al, 2002; Admon et al, 2012) found that individuals with OCD are more risk averse than healthy individuals, while others (Zhang et al, 2015) found no difference These inconsistent findings may be attributed to OCD group size and composition, effects of medication, or lack of control for effects of anxiety, depression, and other comorbidities (Kuelz et al, 2004). …”

Section: Introductionmentioning

confidence: 99%

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Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders

Pushkarskaya

Tolin

Ruderman

et al. 2017

Psychiatry Research

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Difficulties in decision making are a core impairment in a range of disease states. For instance, both obsessive-compulsive disorder (OCD) and hoarding disorder (HD) are associated with indecisiveness, inefficient planning, and enhanced uncertainty intolerance, even in contexts unrelated to their core symptomology. We examined decision-making patterns in 19 individuals with OCD, 19 individuals with HD, 19 individuals with comorbid OCD and HD, and 57 individuals from the general population, using a well-validated choice task grounded in behavioral economic theory. Our results suggest that difficulties in decision making in individuals with OCD (with or without comorbid HD) are linked to reduced fidelity of value-based decision making (i.e. increase in inconsistent choices). In contrast, we find that performance of individuals with HD on our laboratory task is largely intact. Overall, these results support our hypothesis that decision-making impairments in OCD and HD, which can appear quite similar clinically, have importantly different underpinnings. Systematic investigation of different aspects of decision making, under varying conditions, may shed new light on commonalities between and distinctions among clinical syndromes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders

Pushkarskaya

Tolin

Ruderman

et al. 2017

Psychiatry Research

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“…This task has been used to study DM impairments in BD, 17 major depressive disorder (MDD), 5 schizophrenia, 1 and obsessive-compulsive disorder. 18 Although these studies have made important contributions to the literature, additional measures of DM could complement these findings and perhaps address some of the limitations associated with the use of the IGT. These limitations include the difficulty identifying the cognitive processes underlying DM on the task, 19 its sensitivity to context-specific factors such as mood, as well as methodological variability in terms of scoring methods and number of trials.…”

Section: Introductionmentioning

confidence: 96%

Adaptation and validation of the Melbourne Decision Making Questionnaire to Brazilian Portuguese

Cotrena

Branco

Fonseca

2017

Trends Psychiatry Psychother.

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Trends in Psychiatry and Psychotherapy Original ArticleResumo Introdução: A tomada de decisão (TD) é uma das habilidades mais relevantes para a funcionalidade. No entanto, esta habilidade é geralmente avaliada por meio de tarefas comportamentais, cuja validade ecológica tem sido questionada. De acordo com a literatura, a avaliação da TD deve ser complementada por questionários ou escalas, instrumentos estes que não estão disponíveis no português brasileiro. Desta forma, o objetivo deste estudo foi a tradução e validação de uma versão do Melbourne Decision Making Questionnaire (MDMQ), o instrumento mais amplamente utilizado na avaliação da TD, para uso em português. Métodos: A adaptação da MDMQ foi realizada através da tradução, retrotradução, avaliação por painel de juízes e estudo piloto. A versão da escala produzida neste processo foi submetida a análise fatorial e avaliação de consistência interna, levando a exclusão de 4 itens da escala original. A versão resultante da MDMQ, contando com 18 itens no total, foi então utilizada em estudo de validação, em que a TD foi comparada entre adultos saudáveis e portadores de depressão e transtorno bipolar. Resultados:O instrumento demonstrou consistência interna satisfatória, apesar da obtenção de alfas de Cronbach relativamente baixos para a subescala de hipervigilância. A estrutura fatorial do questionário traduzido foi semelhante a observada no instrumento original. Todas as medidas derivadas da MDMQ, mostraram-se discriminativas na comparação entre adultos saudáveis e portadores de transtornos mentais. Conclusão: A versão da MDMQ produzida neste estudo poderá realizar uma importante contribuição para a prática clínica e pesquisa neuropsicológica acerca da TD. Descritores: Tomada de decisões; inquéritos e questionários; psicometria; neuropsicologia. AbstractIntroduction: Decision making (DM) is among the most important abilities for everyday functioning. However, the most widely used measures of DM come from behavioral paradigms, whose ecological validity and standalone use has been criticized in the literature. Though these issues could be addressed by the use of DM questionnaires as a complementary assessment method, no such instruments have been validated for use in Brazilian Portuguese. Therefore, the aim of this study was to conduct the translation and validation of the Melbourne Decision Making Questionnaire (MDMQ) for use in a Brazilian population. Methods: The adaptation of the MDMQ involved the following steps: translation, back-translation, expert review and pilot study. These steps were followed by factor analysis and internal consistency measurements, which led to the exclusion of 4 items from the scale. The 18-item version of the MDMQ was then administered to a validation sample consisting of healthy adults, as well as patients with bipolar disorder (BD) and major depressive disorder (MDD). Results: The instrument displayed good internal consistency, with the hypervigilance subscale showing the lowest, though still acceptable, Cronbach's alpha value. It...

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Neurocognitive Endophenotypes of OCD

Vaghi

2021

The Neurobiology and Treatment of OCD: Accelerating Progress

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Dissociation of decision making under ambiguity and decision making under risk: A neurocognitive endophenotype candidate for obsessive–compulsive disorder

Cited by 51 publications

References 71 publications

Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders

Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders

Adaptation and validation of the Melbourne Decision Making Questionnaire to Brazilian Portuguese

Neurocognitive Endophenotypes of OCD

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