Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone

Choo, Wei-Chieh; Lee, Wei-Wei; Venkatraman, Vinod; Sheu, Fwu‐Shan; Chee, Michael W.L.

doi:10.1016/j.neuroimage.2004.11.029

Cited by 181 publications

(180 citation statements)

References 28 publications

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“…Previous studies have shown a load--related increase in activation in the left thalamus during WM tasks (Altamura et al, 2007;Choo et al, 2005;Nyberg et al, 2009). Furthermore, a specific role for the thalamus during WM maintenance has been proposed by Ashby et al (2005), in which activation during the delay interval is sustained by an excitatory prefrontal cortico--thalamic loop (in conjunction to the fronto--parietal excitatory loop).…”

Section: Discussionmentioning

confidence: 92%

The effect of caffeine on working memory load-related brain activation in middle-aged males

et al. 2013

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Section: Discussionmentioning

confidence: 92%

The effect of caffeine on working memory load-related brain activation in middle-aged males

et al. 2013

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“…TSD effects on frontal lobe functions often include reductions in response inhibition (Harrison and Horne, 1997), complex decision-making (Harrison and Horne, 2000), divergent thinking (Wimmer et al, 1992), word generation and appropriate intonation (Drummond et al, 2001), a delayed-match-to-sample task , and verbal working memory (Mu et al, 2005;Chee and Choo, 2004;Choo et al, 2005). According to Durmer and Dinges (2005), the neurocognitive abilities that are particularly vulnerable to sleep deprivation include executive attention, working memory, and divergent higher cognitive functions.…”

Section: Introductionmentioning

confidence: 99%

Frontal Lobe Metabolic Decreases with Sleep Deprivation not Totally Reversed by Recovery Sleep

Gillin

Buchsbaum

et al. 2006

Neuropsychopharmacol

139

100

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We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.

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“…The response of posterior cortical regions to SD is of interest, because prior experiments involving verbal short-term memory in the context of SD have consistently shown reduced taskrelated activation in the parietal cortex (5)(6)(7)(8). This decline in activation has been shown to reliably correlate with the extent of performance decline in verbal short-term memory after SD.…”

mentioning

confidence: 99%

Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation

Chee

Chuah

2007

Proc. Natl. Acad. Sci. U.S.A.

154

124

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Sleep deprivation (SD) impairs short-term memory, but it is unclear whether this is because of reduced storage capacity or processes contributing to appropriate information encoding. We evaluated 30 individuals twice, once after a night of normal sleep and again after 24 h of SD. In each session, we evaluated visual memory capacity by presenting arrays of one to eight colored squares. Additionally, we measured cortical responses to varying visual array sizes without engaging memory. The magnitude of intraparietal sulcus activation and memory capacity after normal sleep were highly correlated. SD elicited a pattern of activation in both tasks, indicating that deficits in visual processing and visual attention accompany and could account for loss of short-term memory capacity. Additionally, a comparison between better and poorer performers showed that preservation of precuneus and temporoparietal junction deactivation with increasing memory load corresponds to less performance decline when one is sleepdeprived.attention ͉ extrastriate cortex ͉ parietal cortex ͉ functional MRI ͉ fatigue A ir or ship traffic control and long-distance driving, as well as patient status monitoring in intensive care units, are examples where failure to detect, register, and process visual information as a result of sleep deprivation (SD) may have disastrous outcomes. One of the bottlenecks constraining visual information processing is the capacity to capture and briefly retain items in visual short-term memory (VSTM) to detect behaviorally salient events (1).VSTM capacity is limited to approximately four easily discriminated objects (2, 3). The neural substrate for temporary storage of visual information has been localized to the parietal lobes (4). When VSTM is deliberately engaged, the intraparietal sulcus (IPS) in both hemispheres shows a monotonic increase in activation corresponding to set size until memory capacity is reached, whereupon activation asymptotes. When the same arrays are viewed without having to remember the constituent elements, parietal activation is insensitive to perceptual load. In contrast, activation in the extrastriate visual region is sensitive to perceptual load, increasing monotonically with increasing set size (at least up to a set size of eight). These observations provide dissociable regions to examine the neural substrates of storage capacity and perceptual load.The response of posterior cortical regions to SD is of interest, because prior experiments involving verbal short-term memory in the context of SD have consistently shown reduced taskrelated activation in the parietal cortex (5-8). This decline in activation has been shown to reliably correlate with the extent of performance decline in verbal short-term memory after SD. Additionally, we found that of various metrics, response-time variability best correlated with SD-related reduction in posterior parietal activation (9). This suggests that degraded attention rather than loss of storage capacity per se may account for the observed changes in bra...

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Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone

Cited by 181 publications

References 28 publications

The effect of caffeine on working memory load-related brain activation in middle-aged males

The effect of caffeine on working memory load-related brain activation in middle-aged males

Frontal Lobe Metabolic Decreases with Sleep Deprivation not Totally Reversed by Recovery Sleep

Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation

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