Dissociation Constants and Solubilities of Dalbergin and Nordalbergin in Different Solvents

Abstract

The dissociation constants (pK a ) of dalbergin and nordalbergin were measured at 298.2 K using ultraviolet (UV) spectroscopy method. The solubilities of dalbergin and nordalbergin in water, methanol, propanone, ethyl ethanoate, trichloromethane, and hexane have been determined by the UV spectrophotometric method from 283.2 to 308.2 K at atmospheric pressure. The experimental solubility values were correlated with a modified Apelblat equation, λh model, and ideal model. The pK a value of dalbergin is 8.91 ± 0.12, and the pK a1 and pK a2 values of nordalbergin are 7.31 ± 0.29 and 9.79 ± 0.39, respectively. The solubilities of dalbergin and nordalbergin in six solvents increase with an increase in temperature. The solubility order of dalbergin in six pure solvents was trichloromethane > propanone > ethyl ethanoate > methanol > hexane > water, whereas that of nordalbergin was propanone > methanol > ethyl ethanoate > trichloromethane > water > hexane. A comparison of the solubility of dalbergin with that of nordalbergin shows that the 7-methoxyl moiety of dalbergin leads to a significantly higher solubility in trichloromethane and hexane, a little higher solubility in ethyl ethanoate, an approximately equal solubility in propanone, and a little lower solubility in methanol and water (exception 283.2 K). For dalbergin, the modified Apelblat equation shows the best correlation for all solvents, and for nordalbergin, correlation results by three models are similar.

Feasibility of Using 2,3,3,3-Tetrafluoropropene (R1234yf) as a Solvent for Solid–Liquid Extraction of Biopharmaceuticals

“…The absolute values of the calculated solubilities in Table deviate from those obtained experimentally in Table but are in the expected range regarding the quantitative accuracy of COSMO-RS in the prediction of solubility values for solid solutes. − Qualitatively, there is a good agreement in the trend of solubility’s temperature dependence between the experimental and computationally predicted results.…”

Effect of a Neoflavonoid (Dalbergin) on T47D Breast Cancer Cell Line and mRNA Levels of p53, Bcl-2, and STAT3 Genes

“…The species of plant Dalbergia have been applied in traditional medicine as a remedy for blood disorders, ischemia, and inflammation. Neoflavonoids, belonging to the neoflavene family, were initially isolated from Dalbergia sissoo and Dalbergia latifolia (8,9). This polyphenol has shown to have anticancer effects in different tumor cell lines; however, it shows differential cytotoxic activity against tumor and surrounding normal cells (10).…”