Dissociation between the effect of bovine growth hormone in articular cartilage and in bone of the adult dog.

A chondral modeling theory

“…Some inherent difference in the magnitude of responsiveness to mechanical force distinguishes epiphyseal plate from articular cartilage (some published evidence supports this idea [37,39]. Some inherent difference in the magnitude of responsiveness to mechanical force distinguishes epiphyseal plate from articular cartilage (some published evidence supports this idea [37,39].…”

No effect of growth hormone on recovery of load-protected bone Cortical bone mass and strength studied in rabbits

“…Growth hormone is known to affect the metabolism of bone; it is necessary for the normal development and growth of bone (Thorngren 1973). It also increases formation and resorption of bone in the adult skeleton resulting in a net increase in bone mass (Frost 1962, Hams et al 1972, Mankin et al 1978. However, growth hormone does not seem to to affect the healing of fresh fractures (Hams et al 1975, Lindholm et al 1977, Northmore-Ball et al 1980, although it has been reported to enhance the healing of delayed union (Koskinen et al 1978, Ah1 & KalCn 1979.…”

Magnetic resonance imaging of knee hyaline cartilage and intraarticular pathology

“…J Bone Joint Surg 44A. 1962 14 Campbell CJ The healing of cartilage defects Clin Orthop 64 [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63]1969 82 Turner DA, Prodomos CC, Clark JW MR imaging in detecting acute injury of ligaments of the knee Proceedings of the 70th Scientific Assembly and Annual Meeting of the Radiological Society of North Amenca, Washington D C , November 25-30, 1984 83 Wolf GL, Popp C NMR-A pnmer for medical imaging SLACK Incorp, Thorofare, NJ, 1984…”

“…Chondrocytes from immature cartilage are capable of increasing metabolic activity. 21,46-47 However, mature chondrocytes show little potential for replication49 unless a chronic injury situation such as degenerative arthritis is induced.30,31,54,68, 78, 79 Despite their lack of cellular division, adult cartilage cells can increase matrix production in response to various stimuli.9, 10, 34,35,37,39,43,44,48,[50][51][52][53][54][55]62,[71][72][73]76 Various authors have documented the ineffectual response of hyaline cartilage to superficial lacerations.1, 2, 5, 6,13,14,20, 22,24,26,28,45,48,49,61,64,75 Others have stated that superficial lacerations remain stable and only occasionally produce early degenerative arthritis. 56,81 Deep penetrating injuries through the subchondral plate, on the other hand, stimulate a response similar to that of vascular tissue, including hematoma formation, influx of fibroblasts, and vascular ingrowth.…”