Dissociation between Postrhinal Cortex and Downstream Parahippocampal Regions in the Representation of Egocentric Boundaries

Gofman, Xenia; Tocker, Gilad; Weiss, Shahaf; Boccara, Charlotte N; Lu, Li; Moser, May‐Britt; Moser, Edvard I; Morris, Genela; Derdikman, Dori

doi:10.1016/j.cub.2019.07.007

Cited by 66 publications

(95 citation statements)

References 25 publications

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“…Next, we compare neural selectivity in ATN and the retrosplenial cortex (RSC), noting few similarities. Unlike the ATN, we find that RSC is dominated by the coding of arena boundaries in an egocentric frame of reference (Alexander et al 2019; Hinman et al 2019; Gofman et al 2019; see also Peyrache et al 2017; Wang et al 2018; Derdikman, 2009). We also characterized neuronal responses in anterior parts of the hippocampal formation (CA2/CA3).…”

Section: Introductionmentioning

confidence: 60%

“…Here we found that, although 28% of RSC cells were tuned to HD, the majority of these were in fact EBC with weaker but significant responses to HD, such that only 4% of RSC cells were classified as HDC. Over half of EBC in the RSC were significantly tuned to HD (similar to EBC in the parasubiculum and medial enthorinal cortex, Gofman et al 2019), which suggests that the RSC may be involved in combing multiple reference frames (see Clark et al 2018). Note that the population responses appear similar in the granular (animal AA2; Suppl.…”

Section: Discussionmentioning

confidence: 95%

“…We found that about half of RSC neurons encode the egocentric position of the arena’s boundary. The existence of egocentric boundary cells (EBC) was proposed by Derdikman (2009), and EBC were recently identified in the entorhinal cortex (Wang et al 2018, Gofman et al 2019), postrhinal cortex (Gofman et al 2019), parasubiculum (Gofman et al 2019), striatum (Hinman et al 2019) and RSC (Alexander et al 2019). Several studies have described HDC in the RSC (Chen et al 1994a,b; Cho et al 2001; Jacob et al 2017; Lozano et al 2017).…”

Section: Discussionmentioning

confidence: 99%

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Multiplexed code of navigation variables in anterior limbic areas

Laurens

Abrego

Cham

et al. 2019

Preprint

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The brain’s navigation system integrates multimodal cues to create a sense of position and orientation. Here we used a multimodal model to systematically assess how neurons in the anterior thalamic nuclei, retrosplenial cortex and anterior hippocampus of mice, as well as in the cingulum fiber bundle and the white matter regions surrounding the hippocampus, encode an array of navigational variables when animals forage in a circular arena. In addition to coding head direction, we found that some thalamic cells encode the animal’s allocentric position, similar to place cells. We also found that a large fraction of retrosplenial neurons, as well as some hippocampal neurons, encode the egocentric position of the arena’s boundary. We compared the multimodal model to traditional methods of head direction tuning and place field analysis, and found that the latter were inapplicable to multimodal regions such as the anterior thalamus and retrosplenial cortex. Our results draw a new picture of the signals carried and outputted by the anterior thalamus and retrosplenial cortex, offer new insights on navigational variables represented in the hippocampus and its vicinity, and emphasize the importance of using multimodal models to investigate neural coding throughout the navigation system.

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Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Multiplexed code of navigation variables in anterior limbic areas

Laurens

Abrego

Cham

et al. 2019

Preprint

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“…Only recently have externally anchored egocentric representations that extend beyond self-motion been reported (15)(16)(17)(18)(19)(20). Egocentric representations of this nature may anchor to environmental boundaries.…”

Section: Introductionmentioning

confidence: 99%

Egocentric boundary vector tuning of the retrosplenial cortex

et al. 2020

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The retrosplenial cortex is reciprocally connected with multiple structures implicated in spatial cognition, and damage to the region itself produces numerous spatial impairments. Here, we sought to characterize spatial correlates of neurons within the region during free exploration in two-dimensional environments. We report that a large percentage of retrosplenial cortex neurons have spatial receptive fields that are active when environmental boundaries are positioned at a specific orientation and distance relative to the animal itself. We demonstrate that this vector-based location signal is encoded in egocentric coordinates, is localized to the dysgranular retrosplenial subregion, is independent of self-motion, and is context invariant. Further, we identify a subpopulation of neurons with this response property that are synchronized with the hippocampal theta oscillation. Accordingly, the current work identifies a robust egocentric spatial code in retrosplenial cortex that can facilitate spatial coordinate system transformations and support the anchoring, generation, and utilization of allocentric representations.

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“…The transformation from egocentric to allocentric coordinates was proposed to occur in retrosplenial cortex, which has been shown to code both egocentric and allocentric reference frames (Alexander & Nitz, 2015Alexander, Rangel, Tingley, & Nitz, 2018). The prediction of a transformation from egocentric to allocentric coordinate frames was supported by the recent discovery of neurons coding the egocentric position of boundaries in the retrosplenial cortex as well as in associated structures involved in input or output from medial entorhinal cortex (Gofman et al, 2019;Hinman, Chapman, & Hasselmo, 2019;LaChance, Todd, & Taube, 2019). The computational modeling of tranformations from egocentric to allocentric coordinates has been used to model navigation in a range of environments, including navigating around barriers in cluttered environments (Bicanski & Burgess, 2018;Edvardsen, Bicanski, & Burgess, 2020).…”

Section: Data Supports Role In Transformation From Egocentric To Almentioning

confidence: 99%

Overview of computational models of hippocampus and related structures: Introduction to the special issue

et al. 2020

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Extensive computational modeling has focused on the hippocampal formation and associated cortical structures. This overview describes some of the factors that have motivated the strong focus on these structures, including major experimental findings and their impact on computational models. This overview provides a framework for describing the topics addressed by individual articles in this special issue of the journal Hippocampus.

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Dissociation between Postrhinal Cortex and Downstream Parahippocampal Regions in the Representation of Egocentric Boundaries

Cited by 66 publications

References 25 publications

Multiplexed code of navigation variables in anterior limbic areas

Multiplexed code of navigation variables in anterior limbic areas

Egocentric boundary vector tuning of the retrosplenial cortex

Overview of computational models of hippocampus and related structures: Introduction to the special issue

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