Dissociation between numerosity and duration processing in aging and early Parkinson's disease

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults

“…Human lesion studies show that processing of numerosity and of time duration are independent (Cappelletti et al 2011). Moreover, Parkinson's disease patients, who have deficits in DA signaling in the dorsal striatum, are selectively impaired in comparisons of duration but not of numerosity (Dormal et al 2012). This latter finding is consistent with abundant evidence linking deficiencies in DA signaling with overestimation of time (see Merchant et al 2013 for a recent review).…”

Is there a generalized magnitude system in the brain? Behavioral, neuroimaging, and computational evidence

“…Stimulation of the left IPS slowed down performance in a numerosity comparison task, whereas left (or right) IPS stimulation did not affect duration comparison (Dormal et al, 2008). Dormal and colleagues showed a similar dissociation between duration and number processing in non-demented Parkinson's disease patients: Whereas the patient group suffered from a decrease in performance compared to controls in a duration task, this was not the case in a numerosity comparison task (Dormal et al, 2012). Recent research also demonstrated impaired time perception in children with difficulties in numbers and mathematics, but failed to show a correlation between timing performance and mathematical abilities (Hurks and Van Loosbroek, 2012; Vicario et al, 2012).…”

The impact of emotion on numerosity estimation

“…For instance, similar parietal activation is seen when processing time and numerosity (Rao et al, 2001; Pinel et al, 2004; Buhusi and Meck, 2005; Cantlon et al, 2006). However, while the above evidence suggests that a common mechanism may underlie representations of both numerosity and time, other evidence exists which implicates numerosity-specific cognitive mechanisms (e.g., Cohen Kadosh et al, 2008; Dormal et al, 2008, 2012). …”