Dissociation between 2-[18F]fluoro-2-deoxy-D-glucose positron emission computed tomography, ultrasound and clinical assessments in patients with non-severe rheumatoid arthritis, including remission

Rinkin, Charline; Fosse, Pacôme; Malaise, Olivier; Chapelier, Nathalie; Horrion, J; Seidel, Laurence; Albert, Adelin; Hustinx, Roland; Malaise, Michel

doi:10.1186/s41927-021-00196-1

Cited by 4 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In non-severe RA patients, including those in remission, PET/CT results were discordant from US and clinical observations. 38 FDG-PET/CT also provides sensitive monitoring of treatment, being able to predict anti-inflammatory treatment of RA (eg DMARDs and biologics such as anti-TNFa( and rituximab), already within a few weeks after initiation of treatment. [39][40][41] However, no predictive values were found for FDG-PET/CT parameters for successful tapering and/or discontinuation of anti-TNFa.…”

Section: Fdg-pet For Ra Disease Activity Assessment and Monitoringmentioning

confidence: 99%

Update on Imaging of Inflammatory Arthritis and Related Disorders

Jamar

Laken²,

Panagiotidis

et al. 2023

Seminars in Nuclear Medicine

View full text Add to dashboard Cite

Section: Fdg-pet For Ra Disease Activity Assessment and Monitoringmentioning

confidence: 99%

Update on Imaging of Inflammatory Arthritis and Related Disorders

Jamar

Laken²,

Panagiotidis

et al. 2023

Seminars in Nuclear Medicine

View full text Add to dashboard Cite

Optical imaging (HandScan) can identify ultrasound remission in rheumatoid arthritis

Rinkin,

Malaise,

Chauveheid

et al. 2024

BMC Musculoskelet Disord

Self Cite

View full text Add to dashboard Cite

Background Identifying remission is of high importance in rheumatoid arthritis (RA) because remission is associated with less structural progression. We investigated the efficacy of a new optical imaging device, HandScan, to identify RA remission, as defined by ultrasound (US). Methods 61 RA patients were included. Disease activity was evaluated by clinical assessment and US, using gray-scale (GS) and Power Doppler (PD). HandScan determined unitary optical spectral transmission (OST) values for wrists, metacarpophalangeal and proximal interphalangeal joints. At the patient level, three composite HandScan (HS) scores were calculated: total HS score; disease activity score OST (DAS-OST) and DAS-OST without patient global assessment (PtGA). Using ROC curves, we determined HS cut-offs to identify US-defined remission. Results At the joint level, unitary OST values significantly correlated with GS synovitis [odds ratio (OR) 2.43, p < 0.0001] and PD positivity (OR 3.72, p = 0.0002 ). At the patient level, total HS score and DAS-OST were significantly associated with all gray-scale US (GSUS) and power doppler US (PDUS) parameters evaluated (synovitis number and grade, synovial thickness, PD grade) (p < 0.05). The cut-off to identify US-defined remission at the joint level was of 0.92, giving an 81% sensitivity and a 96% positive predictive value (PPV). At the patient level, ROC-curves failed to identify a robust cut-off for the total HS score, but did identify a cut-off (3.68) for DAS-OST to identify US-defined remission, but with lower sensitivity (75%), specificity (56%) and PPV (67%). Conclusions HandScan is a non-invasive optical imaging technique providing OST values that correlate with GSUS and PDUS parameters. In addition, HandScan is able to reliably identify US-defined remission in RA at the joint level, with a good sensitivity and high PPV. At the patient level, HandScan DAS-OST can also determine US remission (while total HS score failed to do so), but with lower performance.

show abstract

Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study

Evbuomwan,

Engelbrecht,

Driver

et al. 2023

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using 99mTc-glucosamine single photon emission computed tomography/computed tomography (SPECT/CT) imaging and compare this radiopharmaceutical's diagnostic performance with ultrasound (US) imaging. This prospective study included 22 participants with active RA and 380 joints were assessed with SPECT/CT and US imaging. SPECT/CT imaging of the joints of interest was performed in each participant three hours after injection of 99mTc-glucosamine, with US imaging of the same joints performed on the same day. The affected joints were qualitatively assessed for 99mTc-glucosamine uptake and compared with the findings on US imaging. Results Abnormal increased uptake of 99mTc-glucosamine, localized specifically to the synovial space, was noted in the affected joints. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 99mTc-glucosamine SPECT/CT imaging were 86%, 60%, 61%, 85% and 73%, respectively. A sensitivity of 100% was noted in the identification of synovitis in the carpal and knee joints. Disease activity in the distal interphalangeal (DIP) joints was not observed with either SPECT/CT or US. Conclusions SPECT/CT imaging with 99mTc-glucosamine is a valuable tool for assessing disease activity in the joints of patients with RA. It has a very high sensitivity in detecting synovitis and it correlates very well with US imaging in this regard.

show abstract

Dissociation between 2-[18F]fluoro-2-deoxy-D-glucose positron emission computed tomography, ultrasound and clinical assessments in patients with non-severe rheumatoid arthritis, including remission

Cited by 4 publications

References 28 publications

Update on Imaging of Inflammatory Arthritis and Related Disorders

Update on Imaging of Inflammatory Arthritis and Related Disorders

Optical imaging (HandScan) can identify ultrasound remission in rheumatoid arthritis

Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study

Contact Info

Product

Resources

About