Dissociating the spatio-temporal characteristics of cortical neuronal activity associated with human volitional swallowing in the healthy adult brain

Furlong, Paul L.; Hobson, Anthony; Aziz, Qasim; Barnes, Gareth R.; Singh, Krish Devi; Hillebrand, Arjan; Thompson, David G.; Hamdy, Shaheen

doi:10.1016/j.neuroimage.2004.02.041

Cited by 96 publications

(88 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These ERDs have also been reported in different swallowing studies before [Dziewas et al, 2003;Furlong et al, 2004;Teismann et al, 2007].…”

Section: Introductionsupporting

confidence: 79%

“…In an MEG study, Furlong et al [2004] examined the temporal patterns of swallowing activation through time-frequency plots using wavelet analysis and showed ERD bilaterally in the sensorimotor cortex in the beta frequency band during human swallowing with a marked reduction of the ERD at the beginning of the volitional swallowing phase [Furlong et al, 2004]. Unlike our study, Furlong et al, instructed their subjects to swallow in response to a visual stimulus and no EMG was recorded to precisely monitor swallowing related-muscle activity.…”

Section: Discussionmentioning

confidence: 64%

See 1 more Smart Citation

Time‐dependent hemispheric shift of the cortical control of volitional swallowing

Teismann

Dziewas

Steinstraeter³

et al. 2007

Human Brain Mapping

View full text Add to dashboard Cite

An important part of the cortical processing of swallowing takes place in the sensorimotor cortex, predominantly in the left hemisphere. However, until now, only deglutition related brain activation with low time resolution exceeding a time interval of 1 s has been reported. In this study, we have examined the chronological sequence of cortical swallowing processing in humans by means of high temporal resolution magnetoencephalography (MEG). The cortical MEG activity was recorded during self-paced volitional swallowing in 10 healthy subjects. Data were analyzed using synthetic aperture magnetometry and the group analysis was performed using a permutation test. Swallowingrelated muscle activity was recorded by electromyography. Within the time interval of 1 s of the most pronounced muscular swallowing execution, the MEG analysis revealed neural activation in the primary sensorimotor cortex. During the first 600 ms, only left hemispheric activation was found, bihemi-

show abstract

“…These ERDs have also been reported in different swallowing studies before [Dziewas et al, 2003;Furlong et al, 2004;Teismann et al, 2007].…”

Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 64%

Time‐dependent hemispheric shift of the cortical control of volitional swallowing

Teismann

Dziewas

Steinstraeter³

et al. 2007

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Because of these advantages, SAM has become an increasingly popular analytic tool for MEG data (Vrba and Robinson, 2001;Hillebrand et al, 2005;Brooks et al, 2005;Hall et al, 2005;Fawcett et al, 2004;Furlong et al, 2004;Singh et al, 2003). Moreover, event-related oscillation as revealed by SAM also has a demonstrable spatial coincidence with the BOLD (blood oxygenation level-dependent) fMRI response (Brookes et al, 2005;Foucher et al, 2003;Singh et al, 2002;Hall et al, 2005;Crone, 1998; See, for a review, Hillebrand et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Neural dynamics for facial threat processing as revealed by gamma band synchronization using MEG

et al. 2007

View full text Add to dashboard Cite

Facial threat conveys important information about imminent environmental danger. The rapid detection of this information is critical for survival and social interaction. However, due to technical and methodological difficulties, the spatiotemporal profile for facial threat processing is unknown. By utilizing Magnetoencephalography (MEG), a brain-imaging technique with superb temporal resolution and fairly good spatial resolution, Synthetic Aperture Magnetometry (SAM), a recently developed source analysis technique, and a sliding window analysis, we identified the spatiotemporal development of facial threat processing in the gamma frequency band. We also tested the dual-route hypothesis by LeDoux who proposed, based on animal research, that there are two routes to the amygdala: a quick subcortical routeand a slower and cortical route. Direct evidence with humans supporting this model has been lacking. Moreover, it has been unclear whether the subcortical route responds specifically to fearful expressions or to threatening expressions in general. We found early event-related synchronizations (ERS) in response to fearful faces in the hypothalamus/thalamus area (10-20 ms) and then the amygdala (20-30 ms). This was even earlier than the ERS response seen to fearful faces in visual cortex (40-50 ms). These data support LeDoux's suggestion of a quick, subcortical thamaloamygdala route. Moreover, this route was specific for fear expressions; the ERS response in the amygdala to angry expressions had a late onset (150-160 ms). The ERS onset in prefrontal cortex followed that seen within the amygdala (around 160-210 ms). This is consistent with its role in higher-level emotional/cognitive processing.

show abstract

“…Numerous techniques have been applied to investigate functional brain activity during swallowing (primarily in healthy individuals), including positron emission tomography (PET) [31][32][33][34], magnetoencephalography (MEG) [35][36][37][38][39], transcranial magnetic stimulation (TMS) [31,[40][41][42], and electroencephalography [43][44][45] (EEG). Functional MRI (fMRI) has been especially useful in studying brain activity during swallowing in normal individuals, mainly because of its high spatial and temporal resolution (ability to detect changes in an image across different spatial locations and over time) for various tissue types, its lack of use of radiation or need for other invasive procedures (needle injections), and its ability to obtain images in any plane [46].…”

mentioning

confidence: 99%

Normal Swallowing and Functional Magnetic Resonance Imaging: A Systematic Review

2007

View full text Add to dashboard Cite

Unknowns about the neurophysiology of normal and disordered swallowing have stimulated exciting and important research questions. Previously, these questions were answered using clinical and animal studies. However, recent technologic advances have moved brain-imaging techniques such as functional magnetic resonance imaging (fMRI) to the forefront of swallowing neurophysiology research. This systematic review has summarized the methods and results of studies of swallowing neurophysiology of healthy adults using fMRI. A comprehensive electronic and hand search for original research was conducted, including few search limitations to yield the maximum possible number of relevant studies. The participants, study design, tasks, and brain image acquisition were reviewed and the results indicate that the primary motor and sensory areas were most consistently active in the healthy adult participants across the relevant studies. Other prevalent areas of activation included the anterior cingulate cortex and insular cortex. Review limitations and suggested future directions are also discussed. KeywordsDeglutition; Deglutition disorders; Functional magnetic resonance imaging An estimated 18 million adults have dysphagia, or swallowing disorders, in the United States [1]. Dysphagia is a condition that becomes more prevalent with increasing age and often results from neurologic damage or disorders such as stroke, Alzheimer's disease, and Parkinson's disease. As a result, much of the research on swallowing disorders has focused on understanding and delineating the neurophysiology of swallowing with the overall goal of increasing the efficacy and accuracy with which diagnosis and intervention procedures are employed.Data from clinical and animal studies have provided the earliest insight into the central control of swallowing. In particular, clinical studies have provided an evolving foundation of thought pertaining to the central control of swallowing. These investigations have characteristically started with a disordered neurologic group (i.e., poststroke population) and combined both anatomical brain-imaging techniques (still pictures of the brain) such as computerized tomography (CT) and/or magnetic resonance imaging (MRI) with a swallowing assessment to correlate damaged brain areas with the presence or type of dysphagia observed. The vast majority of clinical studies have focused on the effects of stroke on swallowing [2][3][4][5][6][7][8][9][10][11][12][13][14][15] This systematic review summarizes studies that have explored the neurophysiology of swallowing in healthy adults using fMRI. The goal of a systematic review is to gather and present objectively the current status of research in a particular area of interest. It presents an unbiased review of the relevant literature by describing the systematic methods for obtaining the relevant literature on this topic. Search Strategies ElectronicAn electronic database search was completed using Medline (Ovid and PubMed), CINAHL, DARE, ACP Journal Club, the Cochrane L...

show abstract

Dissociating the spatio-temporal characteristics of cortical neuronal activity associated with human volitional swallowing in the healthy adult brain

Cited by 96 publications

References 40 publications

Time‐dependent hemispheric shift of the cortical control of volitional swallowing

Time‐dependent hemispheric shift of the cortical control of volitional swallowing

Neural dynamics for facial threat processing as revealed by gamma band synchronization using MEG

Normal Swallowing and Functional Magnetic Resonance Imaging: A Systematic Review

Contact Info

Product

Resources

About