Dissociating thalamic alterations in alcohol use disorder defines specificity of Korsakoff's syndrome

Segobin, Shailendra; Lanièpce, Alice; Ritz, Ludivine; Lannuzel, Coralie; Boudehent, Céline; Cabé, Nicolas; Urso, Laurent; Vabret, François; Eustache, Francis; Beaunieux, Hélène; Pitel, Anne‐Lise

doi:10.1093/brain/awz056

Cited by 77 publications

(61 citation statements)

References 42 publications

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“…Postmortem histology indicates neuronal loss in AV and MD nuclei of brains chronically exposed to alcohol (Belzunegui et al, 1995;Harding et al, 2000). A recent diffusion tensor imaging (DTI) study partially supports these histological findings: probabilistic tractography used to segment the thalamus showed that the MD, which preferentially connects to the prefrontal cortex, is affected by both chronic alcoholism and KS (i.e., untreated thiamine deficiency) while the anterior thalamus, preferentially connected to the hippocampus, is principally affected in KS but not alcoholism per se (Segobin et al, 2019). The current assessment of MR images using semi-automated parcellation of thalamic nuclei did not demonstrate sensitivity of either AV or MD to AUD.…”

Section: Discussionmentioning

confidence: 96%

Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV

Zahr

Sullivan

Pohl

et al. 2019

Human Brain Mapping

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Volumes of thalamic nuclei are differentially affected by disease‐related processes including alcoholism and human immunodeficiency virus (HIV) infection. This MRI study included 41 individuals diagnosed with alcohol use disorders (AUD, 12 women), 17 individuals infected with HIV (eight women), and 49 healthy controls (24 women) aged 39 to 75 years. A specialized, high‐resolution acquisition protocol enabled parcellation of five thalamic nuclei: anterior [anterior ventral (AV)], posterior [pulvinar (Pul)], medial [mediodorsal (MD)], and ventral [including ventral lateral posterior (VLp) and ventral posterior lateral (VPl)]. An omnibus mixed‐model approach solving for volume considered the “fixed effects” of nuclei, diagnosis, and their interaction while covarying for hemisphere, sex, age, and supratentorial volume (svol). The volume by diagnosis interaction term was significant; the effects of hemisphere and sex were negligible. Follow‐up mixed‐model tests thus evaluated the combined (left + right) volume of each nucleus separately for effects of diagnosis while controlling for age and svol. Only the VLp showed diagnoses effects and was smaller in the AUD (p = .04) and HIV (p = .0003) groups relative to the control group. In the AUD group, chronic back pain (p = .008) and impaired deep tendon ankle reflex (p = .0005) were associated with smaller VLp volume. In the HIV group, lower CD4 nadir (p = .008) was associated with smaller VLp volume. These results suggest that the VLp is differentially sensitive to disease processes associated with AUD and HIV.

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Section: Discussionmentioning

confidence: 96%

Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV

Zahr

Sullivan

Pohl

et al. 2019

Human Brain Mapping

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show abstract

“…The resulting losses in recollection, but not familiarity, correlate closely with the extent of mammillary body atrophy (Tsivilis et al 2008). Renewed interest in the mammillary body-anterior thalamic axis has provided novel insights into the memory loss in conditions such as developmental amnesia (Dzieciol et al 2017), Korsakoff's syndrome (Segobin et al 2019), thalamic vascular damage (Carlesimo et al 2011), and Alzheimer's disease (Aggleton et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Cutting out the middleman: Separating attributional biases from memory deficits

Wang

2019

Behav Brain Sci

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“…Thalamic function via corticothalamic or thalamocortical pathways integrates inputs from the PFC and other cortices. Indeed, the PFC and thalamus can be activated by alcohol cues (29), and decreased connectivity in the thalamus-PFC fibre pathway is associated with AUD (30). In addition, a thalamus-dorsomedial-PFC circuit was recently demonstrated to link to social dominance in mice (31).…”

Section: Examining Nki-rs Datamentioning

confidence: 99%

Brain Anatomical Covariation Patterns Linked to Binge Drinking and Age at First Full Drink Prior to 21 Years

Zhao

Constable

Hien

et al. 2020

Preprint

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Binge drinking and age at first full drink of alcohol prior to 21 years (AFD<21) have been linked to neuroanatomical differences in cortical and subcortical grey matter (GM) volume, cortical thickness, and surface area. Despite the potential to reveal novel network-level relationships, structural covariation patterns among these morphological measures have yet to be examined relative to binge drinking and AFD<21. Here, we used the Joint and Individual Variance Explained (JIVE) method to characterize structural covariation patterns common across and specific to morphological measures in 293 participants (149 individuals with binge drinking and 144 healthy controls) from the Human Connectome Project (HCP). An independent dataset (Nathan Kline Institute Rockland Sample; NKI-RS) was used to examine reproducibility/ generalizability. We identified a highly reproducible joint component dominated by structural covariation between GM volume in the brainstem and thalamus proper, and GM volume and surface area in prefrontal cortical regions. Using linear mixed regression models, we found that this joint component was related to AFD<21 in both the HCP and NKI-RS datasets, whereas the individual thickness component associated with binge drinking and AFD<21 in the HCP dataset was not statistically significant in the NKI-RS sample. Taken together, our results show that a highly reproducible structural pattern involving covariation in brain regions relevant to thalamic-PFC-brainstem neural circuitry is linked to age at first full drink.

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Dissociating thalamic alterations in alcohol use disorder defines specificity of Korsakoff's syndrome

Cited by 77 publications

References 42 publications

Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV

Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV

Cutting out the middleman: Separating attributional biases from memory deficits

Brain Anatomical Covariation Patterns Linked to Binge Drinking and Age at First Full Drink Prior to 21 Years

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