Dissociating patterns of anterior and posterior hippocampal activity and connectivity during distinct forms of category fluency

McAndrews, Mary Pat; Pruessner, Jens C.; Moscovitch, Morris

doi:10.1016/j.neuropsychologia.2016.06.028

Cited by 34 publications

(33 citation statements)

References 67 publications

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“…The coordinates for this study was from the posterior part of the hippocampus. Our results are in line with previous reports about the posterior hippocampus to work in concert with regions involved in imagery and perceptual processing to form mental constructions via relational processing (Sheldon et al, 2016a;Sheldon et al, 2016b). Strange and colleagues (1999) also reported the anterior-posterior familiarity gradient, suggesting that increase in familiarity leads to activation of the posterior hippocampus.…”

Section: Age-related Differences In Hippocampal Functional Network Dusupporting

confidence: 93%

Role of the hippocampus during logical reasoning and belief bias in aging

Ziaei

Bonyadi

Reutens

2019

Preprint

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AbstractReasoning requires initial encoding of the semantic association between premises or assumptions, retrieval of these semantic associations from memory, and recombination of information to draw a logical conclusion. Currently-held beliefs can interfere with the content of the assumptions if not congruent and inhibited. This study aimed to investigate the role of the hippocampus and hippocampal networks during logical reasoning tasks in which the congruence between currently-held beliefs and assumptions varies. Participants of younger and older age completed a series of syllogistic reasoning tasks in which two premises and one conclusion were presented and they were required to decide if the conclusion logically followed the premises. The belief load of premises was manipulated to be either congruent or incongruent with currently-held beliefs. Our whole-brain results showed that older adults recruited the hippocampus during the premise integration stage more than their younger counterparts. Functional connectivity using a hippocampal seed revealed that older, but not younger, adults recruited a hippocampal network that included anterior cingulate and inferior frontal regions when premises were believable. Importantly, this network contributed to better performance in believable inferences, only in older adults group. Further analyses suggested that, in older adults group, the integrity of the left cingulum bundle was associated with the higher correct rejection of believable premises more than unbelievable ones. Using multimodal imaging, this study highlights the importance of the hippocampus during premise integration and supports the compensatory role of the hippocampal network during a logical reasoning task among older adults.

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Section: Age-related Differences In Hippocampal Functional Network Dusupporting

confidence: 93%

Role of the hippocampus during logical reasoning and belief bias in aging

Ziaei

Bonyadi

Reutens

2019

Preprint

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“…The hippocampus tail displayed reliable connectivity with Pars Opercularis in 1 out of 2 patients. If confirmed, such hippocampal-prefrontal functional connectivity during word retrieval would add some credence to the involvement of hippocampus in visual word retrieval (Hamamé et al 2014;Llorens et al 2016; see also Covington and Duff 2016;Piai et al 2016;Sheldon et al 2016).…”

Section: Parieto-temporal Networkmentioning

confidence: 88%

“…The evidence for the pathways described above comes from comparative studies in macaque monkeys (e.g., Petrides and Pandya 2009), and, in humans, from metrics derived from structural diffusion tensor imaging (DTI) connectivity and from functional magnetic resonance imaging (fMRI) resting-state connectivity (e.g., Margulies and Petrides 2013;Fuertinger et al 2015;Saur et al 2008;Sheldon et al 2016;Sheldon and Moscovitch 2012;Uddin et al 2010). Comparatively, there are relatively few studies in which functional connectivity analysis are directly derived from word production tasks.…”

Section: Task-related Functional Connectivitymentioning

confidence: 99%

An intracerebral exploration of functional connectivity during word production

et al. 2018

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Language is mediated by pathways connecting distant brain regions that have diverse functional roles. For word production, the network includes a ventral pathway, connecting temporal and inferior frontal regions, and a dorsal pathway, connecting parietal and frontal regions. Despite the importance of word production for scientific and clinical purposes, the functional connectivity underlying this task has received relatively limited attention, and mostly from techniques limited in either spatial or temporal resolution. Here, we exploited data obtained from depth intra-cerebral electrodes stereotactically implanted in eight epileptic patients. The signal was recorded directly from various structures of the neocortex with high spatial and temporal resolution. The neurophysiological activity elicited by a picture naming task was analyzed in the time-frequency domain (10-150 Hz), and functional connectivity between brain areas among ten regions of interest was examined. Task related-activities detected within a network of the regions of interest were consistent with findings in the literature, showing task-evoked desynchronization in the beta band and synchronization in the gamma band. Surprisingly, long-range functional connectivity was not particularly stronger in the beta than in the high-gamma band. The latter revealed meaningful subnetworks involving, notably, the temporal pole and the inferior frontal gyrus (ventral pathway), and parietal regions and inferior frontal gyrus (dorsal pathway). These findings are consistent with the hypothesized network, but were not detected in every patient. Further research will have to explore their robustness with larger samples.

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“…This proposed anterior and posterior MTL network dissociation is reminiscent of the functional distinctions along the longitudinal axis of the hippocampus (Poppenk et al, ; Strange, Witter, Lein, & Moser, ). More specifically, there is a growing body of work showing that the anterior hippocampus is involved in retrieving information on a global/broader (i.e., conceptual) scale whereas the posterior hippocampus is involved in retrieving information with more fine‐grained details, particularly when information has to be retrieved within a specific spatial context (Collin et al, ; Evensmoen et al, ; Sheldon, McAndrews, Pruessner, & Moscovitch, ). These differences have also been associated with specific hippocampal‐cortical networks (McCormick et al, ; Persson, Stening, Nordin, & Soderlund, 2017; Sheldon et al, ).…”

Section: Introductionmentioning

confidence: 99%

The medial temporal lobe functional connectivity patterns associated with forming different mental representations

Levine

2018

Hippocampus

Self Cite

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The medial temporal lobes (MTL), and more specifically the hippocampus, are critical for forming mental representations of past experiences-autobiographical memories-and for forming other "nonexperienced" types of mental representations, such as imagined scenarios. How the MTL coordinate with other brain areas to create these different types of representations is not well understood. To address this issue, we performed a task-based functional connectivity analysis on a previously published dataset in which fMRI data were collected as participants created different types of mental representations under three conditions. One condition required forming and relating together details from a past event (autobiographical task), another required forming and relating together details of a spatial context (spatial task) and another condition required relating together conceptual/perceptual features of an object (conceptual task). We contrasted the connectivity patterns associated with a functionally defined region in the parahippocampal cortex (PHC) and anatomically defined anterior and posterior hippocampal segments across these tasks. Examining PHC connectivity patterns revealed that the PHC seed was distinctly connected to other MTL structures during the autobiographical task, to posterior parietal regions during the spatial task and to a distributed network of regions for the conceptual task. Examining hippocampal connectivity patterns revealed that the anterior hippocampus was preferentially connected to regions of default mode network during the autobiographical task and to areas implicated in semantic processing for the conceptual task whereas the posterior hippocampus was preferentially connected to medial-posterior regions of the brain during the spatial task. We interpret our findings as evidence that there are MTL-guided networks for forming distinct types of mental representations that align with functional distinctions within the hippocampus.

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Dissociating patterns of anterior and posterior hippocampal activity and connectivity during distinct forms of category fluency

Cited by 34 publications

References 67 publications

Role of the hippocampus during logical reasoning and belief bias in aging

Role of the hippocampus during logical reasoning and belief bias in aging

An intracerebral exploration of functional connectivity during word production

The medial temporal lobe functional connectivity patterns associated with forming different mental representations

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