Dissociating effects of aging and genetic risk of sporadic Alzheimer’s disease on path integration

Colmant, Lise; Bierbrauer, Anne; Bellaali, Youssef; Kunz, Lukas; Dongen, Jasper Van; Sleegers, Kristel; Axmacher, Nikolai; Lefèvre, Philippe; Hanseeuw, Bernard

doi:10.1016/j.neurobiolaging.2023.07.025

Cited by 7 publications

(10 citation statements)

References 56 publications

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“…Recently, Newton et al reported that entorhinal-based PI selectively predicts the midlife risk of AD in asymptomatic adults, linking it to early neurodegenerative changes before other cognitive declines are observable [29] . Our results also confirmed that the presence of the APOE ε4 allele is significantly associated with increased PI errors [13,30,31] . These results support the idea that immersive VR to measure PI can effectively reveal early-stage AD-related changes.…”

Section: Discussionsupporting

confidence: 86%

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers

Shima,

Ohdake,

Mizutani

et al. 2024

Preprint

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BACKGROUND: We investigated the association between path-integration (PI) errors related to entorhinal cortex function detectable using a 3D virtual reality (VR) navigation system and various biomarkers to explore its potential as an early AD indicator. METHODS: The PI capabilities of 111 healthy adults were assessed using a head-mounted 3D VR system. Demographic and cognitive assessments, AD-related plasma biomarkers, and apolipoprotein E genotypes were also evaluated. Predictive factors for PI errors were identified using multivariate linear regression, logistic regression, and random forest. RESULTS: PI errors positively correlated with age, plasma levels of glial fibrillary acidic protein [GFAP], neurofilament light, and p-tau181. Multivariate analysis identified plasma GFAP and p-tau181 levels as significant predictors. Random forest analysis and receiver operating characteristic curves underscored plasma p-tau181 levels as the most substantial predictor. DISCUSSION: PI errors, particularly in conjunction with plasma p-tau181 levels, could reflect early AD pathophysiology, highlighting their potential as early biomarkers.

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Section: Discussionsupporting

confidence: 86%

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers

Shima,

Ohdake,

Mizutani

et al. 2024

Preprint

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“…One possibility is that older adults were less effective than young adults at using the distal landmark cues to navigate. Recent findings suggest that the ability to orient and navigate with reference to external landmarks declines during healthy aging (Colmant et al, 2023; West et al, 2023), and that older adults may benefit from boundary cues (Bécu et al, 2019; 2023). Therefore, in the second experiment, we included a circular boundary wall located outside the perimeter of the navigable space (diameter = 20 virtual meters).…”

Section: Methodsmentioning

confidence: 99%

Age differences in spatial memory are mitigated during naturalistic navigation

Hill

McAvan

Garren

et al. 2023

Preprint

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Spatial navigation deficits in older adults are well documented. These findings are based on experimental paradigms that require using a joystick or keyboard to navigate a virtual desktop environment. In the present study, cognitively normal young and older adults navigated in each of two virtual reality (VR) conditions: a desktop VR condition which required using a mouse and keyboard to navigate and an immersive and ambulatory VR condition which permitted unrestricted locomotion. Consistent with past studies, older adults navigated to target locations less precisely than did younger individuals in the desktop condition. These age differences were significantly attenuated when tested in the immersive environment. Additional analyses indicated that older adults showed a preference for route-based search strategies compared to young adults, regardless of condition. These findings suggest that certain aspects of navigation performance in older adults are improved in paradigms that offer a fuller range of enriched and naturalistic cues.

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“…It has also been demonstrated that virtual and ecological SN tasks can detect the SN alteration of amyloid-positive MCI patients [89,90]. According to Colmant et al [91], we also presume that APOE-ε4 carriers will report a PPI deficit in the VR task differently from non-carriers, regardless of subgroup.…”

Section: Discussionmentioning

confidence: 73%

Exploring the Remediation of Behavioral Disturbances of Spatial Cognition in Community-Dwelling Senior Citizens with Mild Cognitive Impairment via Innovative Technological Apparatus (BDSC-MCI Project): Protocol for a Prospective, Multi-Center Observational Study

Cammisuli,

Tuena,

Riva

et al. 2024

JPM

Self Cite

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Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer’s disease (AD), which occurs as a result of progressive neuropathology involving specific brain areas. Moreover, the epsilon 4 isoform of apolipoprotein-E (APOE-ε4) has been associated with both sporadic and familial late-onset AD, and patients with mild cognitive impairment (MCI) due to AD are more likely to progressively deteriorate. Spatial navigation performance will be examined on a sample of 76 community-dwelling senior citizens (25 healthy controls; 25 individuals with subjective cognitive decline (SCD); and 26 patients with MCI due to AD) via a virtual computer-based task (i.e., the AppleGame) and a naturalistic task (i.e., the Detour Navigation Test—modified version) for which a wearable device with sensors will be used for recording gait data and revealing physiological parameters that may be associated with spatial disorientation. We expect that patients with MCI due to AD and APOE-ε4 carriers will show altered SN performances compared to individuals with SCD and healthy controls in the experimental tasks, and that VR testing may predict ecological performance. Impaired SN performances in people at increased risk of developing AD may inform future cognitive rehabilitation protocols for counteracting spatial disorientation that may occur during elders’ traveling to unfamiliar locations. The research protocol has been approved by the Ethics Committee of the Istituto Auxologico Italiano. Findings will be published in peer-reviewed medical journals and discussed in national and international congresses.

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Dissociating effects of aging and genetic risk of sporadic Alzheimer’s disease on path integration

Cited by 7 publications

References 56 publications

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers

Age differences in spatial memory are mitigated during naturalistic navigation

Exploring the Remediation of Behavioral Disturbances of Spatial Cognition in Community-Dwelling Senior Citizens with Mild Cognitive Impairment via Innovative Technological Apparatus (BDSC-MCI Project): Protocol for a Prospective, Multi-Center Observational Study

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