Dissociated vertical deviation: evidence of abnormal visual pathway projection.

Pattern- and flash-evoked potentials in patients with dissociated vertical deviation

“…The results of the present study do not support the conclusions of Fitzgerald and Billson [1] that most patients with DVD appear to have an anomalous visual pathway similar to that reported to occur in ocular albinos [2]. In our group of patients with DVD and good binocular Snellen acuities, a 0-14 ~ radius half-field stimulus produced similar occipital distributions of pattern reversal responses in both DVD patients and matched controls.…”

“…Nor did we find significant differences when assessing left/right differences in lateral responses following independent flash stimulation of each eye. Asymmetries in flash responses are reported to occur in albinism [2] but this type of stimulus was not used by Fitzgerald and Billson [1].…”

“…However, we have noted that pattern responses in these patients are not completely normal and we suggest reasons for this and for the anomalous pattern of asymmetry described by Fitzgerald and Billson [1].…”

“…DVD is commonly found in patients with infantile esotropia, although it may not be clinically apparent until some years after birth. Fitzgerald and Billson [1] reported that most patients with DVD have pattern reversal visual evoked potentials (PVEPs) which are delayed and show abnormalities to half-field stimulation, indicating anomalies in retino-cortico fiber projection similar to that reported to occur in albinos [2].…”

Unilateral Optic Nerve Hypoplasia with Contralateral Optic Pathway Hypoplasia: A Case Report

“…Abnormalities in temporal retinal projections have been reported in albinos, 5 Chédiak-Higashi syndrome, 6 chiasmal lesions, 7 congenital nystagmus, 8 and in dissociated vertical deviation (DVD). 9 The bilaterally asymmetric, photically evoked potentials after monocular illumination in human albinos suggest that there is a disorganization of the nondecussated optic fibres similar to that reported for albino mammals. As yet there is no histological confirmation of abnormal retinostriate projections in humans, and there are no reports on asymmetry by MRI and MRDTI in human albinos.…”