Dissipation of antibiotics by microalgae: Kinetics, identification of transformation products and pathways

Kiki, Claude; Rashid, Abbas; Wang, Yuwen; Li, Yan; Zeng, Qiaoting; Yu, Chang-Ping; Sun, Qian

doi:10.1016/j.jhazmat.2019.121985

Cited by 146 publications

(54 citation statements)

References 54 publications

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“…This low OT removal by hydrolysis was likely due to its relatively higher water partitioning coefficient and lower water solubility with the log Kow of 0.95 ( Olisah et al, 2021 ). Moreover, photolysis induced 9.0% OT removal, and it was in agreement with a 5-14% photolytic removal of sulfamerazine, sulfamethoxazole, levofloxacin, and flumequine by microalgae ( Kiki et al, 2020 ). The photolytic loss was primarily governed by light irradiation through the cleavage of C-H and C-N bonds, hydrogen abstraction of radicals, disproportionation of alkyl radicals, and the consecutive free-radical oxidations ( Luo et al, 2020 ).…”

Section: Resultssupporting

confidence: 78%

“…The dissolved, bioadsorbed, bioaccumulated, and biodegraded fractions of OT were determined by a recent method ( Kiki et al, 2020 ). Firstly, the residual OT concentration was routinely quantified by using HPLC (instrument: U3000-UV, Agilent, USA) at electrospray ionization (+ESI) mode.…”

Section: Methodsmentioning

confidence: 99%

“…Removal rates of sulfamethoxazole (99.3%) and methylpenantherine (99.8%) were achieved by C. pyrenoidosa and Pseudokirchneriella subcapitata, respectively ( Xiong et al, 2020 ). Similarly, Haematococcus pluvialis , C. vulgaris , and S elenestrum capricornutum achieved almost complete removal of trimethoprim, azithromycin, and levofloxacin, respectively ( Kiki et al, 2020 ). Nonetheless, due to increasing global consumption, knowledge of the occurrence, transport, and ecotoxicity implications of AVDs and their metabolites in downstream environments is essential.…”

Section: Introductionmentioning

confidence: 99%

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Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Zeeshan

Qiu

et al. 2022

Journal of Hazardous Materials

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Increased worldwide consumption of antiviral drugs (AVDs) amid COVID-19 has induced enormous burdens to the existing wastewater treatment systems. Microalgae-based bioremediation is a competitive alternative technology due to its simultaneous nutrient recovery and sustainable biomass production. However, knowledge about the fate, distribution, and interaction of AVDs with microalgae is yet to be determined. In this study, a concentration-determined influence of AVD oseltamivir (OT) was observed on the biochemical pathway of Chlorella sorkiniana (C.S-N1) in synthetic municipal wastewater. The results showed that high OT concentration inhibited the biomass growth through increased oxidative stress, and restrained photosynthesis. Nevertheless, complete OT removal was achieved at its optimized concentration of 10 mg/L by various biotic (82%) and abiotic processes (18.0%). The chemical alterations in three subtypes of extracellular polymeric substances (EPS) were primarily investigated by electrostatic (OT +8.22 mV vs. C.S-N1 -18.31 mV) and hydrophobic interactions between EPS-OT complexes supported by secondary structure protein analysis. Besides, six biodegradation-catalyzed transformation products were identified by quadrupole-time-of-flight mass spectrometer and by density functional theory. Moreover, all the TPs exhibited log Kow ≤ 5 and bioconcentration factor values of < 5000 L/kg, meeting the practical demands of environmental sustainability. This study broadens our understanding of microalgal bioadsorption and biodegradation, promoting microalgae bioremediation for nutrient recovery and AVDs removal.

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Section: Resultssupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Zeeshan

Qiu

et al. 2022

Journal of Hazardous Materials

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“…Five phase I metabolites (TMP277, TMP261, TMP305, TMP307, and TMP325) were formed by hydroxylation, oxidation, demethylation, or dehydroxylation reactions. These reactions have also been reported during TMP degradation by nitrifying sludge bacteria [49], algae [44], and biological wastewater treatment [50]. Hydroxylation of TMP has been reported as the most prevalent reaction of biotransformation by algae [44], and during degradation in soil [51].…”

Section: Biotransformation Reactionsmentioning

confidence: 78%

“…These reactions have also been reported during TMP degradation by nitrifying sludge bacteria [49], algae [44], and biological wastewater treatment [50]. Hydroxylation of TMP has been reported as the most prevalent reaction of biotransformation by algae [44], and during degradation in soil [51]. In addition, Kiki et al [44] reported several other degradation products during algae treatment, which were formed mainly by TMP cleavage and thus considered phase I.…”

Section: Biotransformation Reactionsmentioning

confidence: 87%

Systematic identification of trimethoprim metabolites in lettuce

et al. 2022

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Antibiotics are some of the most widely used drugs. Their release in the environment is of great concern since their consumption is a major factor for antibiotic resistance, one of the most important threats to human health. Their occurrence and fate in agricultural systems have been extensively investigated in recent years. Yet whilst their biotic and abiotic degradation pathways have been thoroughly researched, their biotransformation pathways in plants are less understood, such as in case of trimethoprim. Although trimethoprim has been reported in the environment, its fate in higher plants still remains unknown. A bench-scale experiment was performed and 30 trimethoprim metabolites were identified in lettuce (Lactuca sativa L.), of which 5 belong to phase I and 25 to phase II. Data mining yielded a list of 1018 ions as possible metabolite candidates, which was filtered to a final list of 87 candidates. Molecular structures were assigned for 19 compounds, including 14 TMP metabolites reported for the first time. Alongside well-known biotransformation pathways in plants, additional novel pathways were suggested, namely, conjugation with sesquiterpene lactones, and abscisic acid as a part of phase II of plant metabolism. The results obtained offer insight into the variety of phase II conjugates and may serve as a guideline for studying the metabolization of other chemicals that share a similar molecular structure or functional groups with trimethoprim. Finally, the toxicity and potential contribution of the identified metabolites to the selective pressure on antibiotic resistance genes and bacterial communities via residual antimicrobial activity were evaluated.

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Ecotoxicological assessment, in freshwater environment, of wastewater sludge coupled and uncoupled with micro‐polyvinyl chloride on algae and water fleas

Pignattelli,

Provenza,

Rampih

et al. 2024

Water Environment Research

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In the frame of bioeconomy and circular economy, wastewater sludge (WS) could be a good candidate for its use in agriculture as fertilizer, due to its high content of organic matter, N and P, but on the other hand, it is full of toxicants such as heavy metal, microplastics, detergent, antibiotics, and so on that can reach groundwater and water bodies in leachate form. In this study, we have investigated different sludge concentrations in the eluate form, combined and not with PVC on two different freshwater organisms Selenastrum capricornutum and Daphnia magna, using ecotoxicity tests. At the endpoint, we have evaluated inhibition growth rate, oxidative stress, and pigments production for S. capricornutum, while in case of D. magna, we have assessed organism immobilization and development. From our results, it emerged that at the higher WS concentration, there was not inhibition growth rate, while at oxidative stress, it was higher in algae treated with WS and PVC. Higher Chl‐a production was shown for algae treated with 0.3 g/L of sludge coupled with PVC, where higher phaeopigments production were recorded for algae treated with 0.3 g/L of WS. D. magna has shown an opposite trend when compared with algae, where at the highest WS concentrations supplied was corresponding to an increased mortality explaned as the highest immobility percentage.Practitioner Points Wastewater sludge is used in agriculture as fertilizer. PVC microplastic presence and associate ecotoxicity was tested. PVC presence increased oxidative stress in S. capricornutum. D. magna was significantly affected by sludge concentrations supplied.

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Dissipation of antibiotics by microalgae: Kinetics, identification of transformation products and pathways

Cited by 146 publications

References 54 publications

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Systematic identification of trimethoprim metabolites in lettuce

Ecotoxicological assessment, in freshwater environment, of wastewater sludge coupled and uncoupled with micro‐polyvinyl chloride on algae and water fleas

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