Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies

Lauricella, Ana María; Garbossa, Graciela; Nesse, Alcira

doi:10.1016/s1567-5769(01)00082-0

Cited by 9 publications

(2 citation statements)

References 39 publications

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“…There is some evidence that repeated exposure to high doses of different Al forms may stimulate (Lauricella et al 2001, Yoshida et al 1989) or suppress the immune response in rodents (Golub et al 1993, Khalaf et al 2008, Yoshida et al 1989). Tsunoda and Sharma (1999) found no change in mRNA expression for cytokines TNF α, IL-1 β, and INFγ in peripheral cells of the immune system (TNF α and IL-1βin splenic macrophages and INFγ in splenic lymphocytes) of mice given Al 2 (SO 4 ) 3 in their drinking water at 0, 5, 25 or 125 mg/L (equivalent to 0, 0.95, 4.3, and 21 mg Al/kg-day) for one month.…”

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

333

201

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Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability.Address for correspondence: Calvin C. Willhite, Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON, Canada. calvinwillhite@hotmail.com. Declaration of interestPartial funding for this work was provided by a contract to review the recent scientific literature on health effects of aluminum between the International Aluminium Institute (IAI, www.world-aluminium.org), the Aluminium Reach Consortium (ARC, www.aluminium-reach-consortium.eu), and Risk Sciences International (RSI, www.risksciences.com), a Canadian company established in 2006 in partnership with the University of Ottawa. Additional financial support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) to D. Krewski, who holds the NSERC Chair in Risk Science at the University of Ottawa. C.C. Willhite, N.A. Karyakina, F. Momoli, and N. Yenugadhati were compensated by RSI for their contributions to the review. I. Arnold, T. Wisniewski and R. Yokel received no compensation from RSI for their contributions to this work. The authors, whose affiliations are shown on the title page, had sole responsibility for preparation of this paper, including determining the strategy for reviewing the scientific literature summarized in this article, synthesizing the findings, and drawing conclusions. Scientists associated with IAI/ARC were given the opportunity to review and offer technical comments on the paper, prior to submission to Critical Reviews in Toxicology. I. Arnold serves as a consultant to the International Aluminium Institute. None of the authors have appeared before regulatory agencies on behalf of the sponsors, or appeared as experts in legal proceedings concerning matters reviewed in this paper. The scientific opinions and conclusions expressed in the paper are exclusively those of the authors, and are independent of the sources of financial support. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

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Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

333

201

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“…Some studies have shown that AI possesses immunological effects (21). There are few published report on immune effect of AI exposure.…”

mentioning

confidence: 99%

Neurobehavioral, Autonomic Nervous Function and Lymphocyte Subsets among Aluminum Electrolytic Workers

Qiao

Wang³

2003

Int J Immunopathol Pharmacol

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The purpose of our study is to determine the alteration of neurobehavioral parameters, autonomic nervous function and lymphocyte subsets in aluminum electrolytic workers of long-term aluminum exposure. Thirtythree men who were 35.16 ± 2.95 (mean ± S.D) years old occupationally exposed to aluminum for 14.91 ± 6.31 (mean ± S.D) years. Air AI level and urinary aluminum concentration were measured by means of graphite furnace atomic absorption spectrophotometer. Normal reference groups were selected from a flour plant. Neurobehavioral core test battery (NCTB) recommended by WHO was utilized. Autonomic nervous function test battery recommended by Ewing DJ was conducted on subjects. FAC SCAN was used to measure the lymphocyte subsets of peripheral blood. The mean air aluminum level in the workshop was 6.36 mg/nr', ranged from 2.90 to 11.38 mg/m', Urinary aluminum of the AI electrolytic workers (40.08 ± 9.36 microgram/mg.cre) was obviously higher than that of control group (26.84 ± 8.93m/mg.cre). Neurobehavioral results showed that the scores of DSY, PAC and PA in AI electrolytic workers were significantly lower than those of control group, The scores of POMSC, POMSF and SRT among AI exposed workers were significantly augmented in relation to those of control group. The scores of SRT and SRTF were obviously decreased in AI exposed group compared to control group. Autonomic nervous function test results showed that R-R interval variability of max:min ratio of immediately standing up in AI electrolytic workers were decreased compare with the control group, while the BP-IS, HR-V, HR-DB, R 311 : 15 had no significant change. Peripheral blood lymphocyte subsets test showed that CD4'CD8+ T lymphocyte in AI electrolytic workers increased. This study suggests that AI exposure exerts adverse effects on neurobehavioral performance, especially movement coordination and negative mood, and parasympathetic nervous function; moreover it increase CD4-CD8+ T lymphocyte subsets.

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Influence of chelating therapy against aluminum chloride-induced immune suppression and hematological disorders in rabbits

2011

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Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies

Cited by 9 publications

References 39 publications

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Neurobehavioral, Autonomic Nervous Function and Lymphocyte Subsets among Aluminum Electrolytic Workers

Influence of chelating therapy against aluminum chloride-induced immune suppression and hematological disorders in rabbits

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