Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response
Lara S.U. Schwab,
Thi H. T. Do,
Marios Koutsakos
Abstract:The global burden of disease caused by Influenza B virus (IBV) is substantial, however IBVs remain overlooked. Understanding host-pathogen interactions as well as establishing physiologically relevant models of infection are important for the development and assessment of therapeutics and vaccines against IBV. Here, we assessed an upper respiratory tract (URT)-restricted model of mouse IBV infection, comparing it to the conventional administration of virus to the total respiratory tract (TRT). We found that UR… Show more
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