Disseminated superficial actinic porokeratosis occurring in two members of an Asian family

Abstract

Disseminated superficial actinic porokeratosis (DSAP) is a genodermatosis which usually affects fair-skinned individuals at sites of chronic sun exposure, although the face is usually spared. We now report the occurrence of this condition in a Pakistani mother and her 13-year-old daughter, both predominantly with facial lesions.

Identification of a Locus for Disseminated Superficial Actinic Porokeratosis at Chromosome 12q23.2–24.1

“…The cutaneous lesions, which occur primarily in sun-exposed areas of the skin, begin to develop in the teenagers of affected families, with penetrance nearly complete by the third and fourth decades of life. The earliest onset of the disease reported previously is 13 y (Holmes et al, 1997). In this study, the earliest onset of DSAP is 12 y.…”

Congenital facial linear porokeratosis

“…Facial porokeratosis is reported to be solar, superficial, destructive, or a segmental manifestation of DSAP and PM. [5][6][7][8][9] The pathogenesis and heritable pattern of congenital LP is unknown. Congenital LP is regarded as a genetic mosaic form of porokeratosis in which the pattern of affected and healthy skin often follows the lines of Blaschko.…”

“…Congenital LP is most commonly located on the extremities, 1–3 and unusually on face. Facial porokeratosis is reported to be solar, superficial, destructive, or a segmental manifestation of DSAP and PM 5–9 …”

Disseminated superficial actinic porokeratosis

“…2 Involvement of the face, mucosae, palms and soles is infrequent. 4 Lesions generally develop in areas exposed to the sun or become more prominent in the summer months. 2 Most lesions are asymptomatic.…”