Disseminated sporotrichosis in an immunocompetent patient

Hassan, Kareem E.; Türker, Tolga; Zangeneh, Tirdad T.

doi:10.3109/23320885.2016.1168703

Cited by 14 publications

(25 citation statements)

References 16 publications

(18 reference statements)

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“…Subsequently, in the majority of cases, nodules develop in the infection site leading to ulceration (Kauffman, 1999). Poorly controlled sporotrichosis can disseminate to distant anatomical sites, including bones, lungs, and central nervous system (Ferreira et al., 2016; Hassan et al., 2016; Rodrigues et al., 2016; Mialski et al., 2018). Apart from being a global health problem, sporotrichosis is hyperendemic in Brazil, mainly due to the zoonotic and crossed transmission of S. brasiliensis from infected felines (Montenegro et al., 2014; Sanchotene et al., 2015; Gremião et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Ploidy Determination in the Pathogenic Fungus Sporothrix spp.

et al. 2019

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The pathogenic clade of the Sporothrix genus comprises the etiological agents of sporotrichosis, a worldwide emergent disease. Despite the growing understanding of their successful pathogen traits, there is little information on genome sizes and ploidy within the genus. Therefore, in this work, we evaluated the ploidy of four species of the Sporothrix genus, specifically Sporothrix brasiliensis , Sporothrix schenckii , Sporothrix globosa , and Sporothrix pallida . Through cell cycle analysis of the yeast-phase cells, we showed that the DNA content of G 0 /G 1 cells was similar to the genome size determined by whole genome sequencing. Moreover, ploidy of S. schenckii , S. brasiliensis , and S. pallida that was determined by allele composition using next-generation sequencing (NGS) data is consistent with monomorphic positions at each allele. These data show that the analyzed strains of Sporothrix are haploid, or at least aneuploid, thereby laying the foundation for the development of a molecular toolbox for Sporothrix spp.

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Section: Introductionmentioning

confidence: 99%

Ploidy Determination in the Pathogenic Fungus Sporothrix spp.

et al. 2019

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“…It has mostly been documented in HIV patients and there are very few case reports of this disease in immunocompetent or non-HIV positive patients. Multiple cases of disseminated sporotrichosis have been reported in patients with HIV [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] Even more rarely, this has been seen in patients without HIV who were otherwise immunocompromised, including diabetes [7] , alcoholism [7] , [8] , and undergoing immunosuppressive therapies [10] . A comprehensive literature search reveals no cases of disseminated sporotrichosis in completely nonimmunosuppressed patients.…”

Section: Discussionmentioning

confidence: 99%

A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia

Yagnik

Skelton

Olson

et al. 2017

IDCases

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Sporothrix schenckii is a pathogen with a predilection for dissemination in immunocompromised individuals, often with HIV.We report a case of disseminated sporotrichosis in an unfortunate 25 year old male (without HIV) who was originally treated for presumed pneumonia. The patient continued to worsen clinically and further work-up eventually revealed Sporothrix schenckii species with involvement of multiple organs including the skin, heart, lungs and bone marrow. Despite treatment with multiple antibacterials and antifungals, he ultimately passed away.This case illustrates the aggressive nature of this disease along with the importance of early/proper diagnosis and treatment.

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“…However, even immunocompetent hosts, especially those with heavy alcohol intake or poorly controlled diabetes, can develop both lymphocutaneous and disseminated disease (Table 1) [5]. Dissemination occurs in ~1% of cases [6], presenting with cutaneous features that include numerous nodules that often ulcerate [7]. Osteoarticular involvement is a common feature of disseminated disease, usually manifesting as large-joint monoarthritis [1].…”

Section: Diagnosis: Disseminated Sporotrichosismentioning

confidence: 99%

Disseminated Cutaneous and Osteoarticular Sporotrichosis Mimicking Pyoderma Gangrenosum

Saeed

Weber

Puryear

et al. 2019

Open Forum Infectious Diseases

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Disseminated sporotrichosis may present with inflammatory arthritis and cutaneous ulcerations that mimic non-infectious skin conditions such as pyoderma gangreonsum (PG). Sporotrichosis must therefore be ruled out before administering immunosuppressive agents for PG. Furthermore, dimorphic fungi such as sporotrichosis may grow as yeast in bacterial cultures, even before fungal cultures become positive. We present a case of disseminated cutaneous and osteoarticular sporotrichosis mimicking PG and describe the differential diagnosis as well as the diagnostic and treatment approach to this condition.

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Disseminated sporotrichosis in an immunocompetent patient

Cited by 14 publications

References 16 publications

Ploidy Determination in the Pathogenic Fungus Sporothrix spp.

Ploidy Determination in the Pathogenic Fungus Sporothrix spp.

A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia

Disseminated Cutaneous and Osteoarticular Sporotrichosis Mimicking Pyoderma Gangrenosum

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