Disseminated Rhodococcus equi infection in a patient with Hodgkin’s lymphoma

Mikić, Dragan; Djordjevic, Zoran; Kojič, Miroslav; Tomanovic, Branka

doi:10.2298/vsp121218035m

Cited by 5 publications

(5 citation statements)

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“…Later, due to the increasing number of HIV infections, the development of transplantation, and diagnostic methods, the number of diagnosed cases of R. equi surged in apparently immunocompetent individuals. Nowadays, the amount of infection in immunocompromised people is growing, which is highly alarming due to the emerging antibiotic resistance of R. equi [ 8 , 33 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

“…Pneumonia is the most common manifestation in humans, but EPDs, including pericarditis, mastitis, empyema, pericarditis, mediastinal and intra-abdominal lymphadenopathy, brain and psoas abscesses, osteomyelitis, and spondylodiscitis are also observed. There are also cases of sepsis in preterm infants who had respiratory distress [ 8 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

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Rhodococcus equi—Occurrence in Goats and Clinical Case Report

et al. 2021

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Background: Rhodococcus equi infection is commonly known in equine medicine to cause frequently fatal rhodococcosis. Infections in other species and people are also reported. Clinical manifestation in goats is relatively similar to horses and humans, but data regarding bacterium prevalence are scarce. Thus, the study aimed to estimate the occurrence of R. equi in goats. Methods: During post mortem examination, submandibular, mediastinal, and mesenteric lymph nodes were collected. Standard methods were used for bacteria isolation and identification. Results: A total of 134 goats were examined, and 272 lymph node samples were collected. R. equi was isolated from four animals. All four isolates carried the choE gene, and one also had traA and pVAPN plasmid genes. Conclusions: To the authors’ best knowledge, this is the first report of R. equi occurrence and genetic diversity in goats. The results may help create a model for treating rhodococcosis in other animal species and assessing the role of meat contamination as a potential source of human infection. This research should be considered a pilot study for further application of the goat as a model of R. equi infection in horses and humans.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rhodococcus equi—Occurrence in Goats and Clinical Case Report

et al. 2021

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“…Nonetheless, the heterogenic clinical presentation is seldom limited to this population alone. The variation present in this study, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 consistent with overall spinal infection cases, urges additional research within other subsets to construct reliable diagnosis patterns. Because this is the first systematic review of PSI in a previously unexplored population, its purpose is to supplement the aforementioned goal of ultimately guiding clinical decision making for PSI patient populations.…”

Section: Discussionmentioning

confidence: 64%

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

et al. 2023

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Purpose: Primary spinal infections (PSIs) are a group of infectious diseases characterized by inflammation of the end plate-disk unit or its surroundings. PSI is considered more prevalent and aggressive among patients with chronic immunocompromised states. Association of PSIs, immunocompromising cancers, and hemoglobinopathies has not been systematically analyzed. We conducted a systematic review to study characteristics, clinical presentation, and mortality of patients with PSI in the setting of hematologic disease. Methods: A systematic literature search in PubMed, Web of Science, and Scopus was conducted in April 2022 in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included retrospective case series and individual case reports. Results: On careful review, 28 articles published between 1970 and 2022 were selected. These studies featured 29 patients who met inclusion criteria (mean age 29 years, age range 1.5 to 67 years; 63.3% male). Lumbar infection was the most common location (65.5%), with Salmonella (24.1%) as the main causative microorganism. Neurologic compromise was present in 41% of patients, and surgical intervention occurred in 48.3%. Average antibiotic duration was 13 weeks. The postoperative complication rate was 21.4%, with a mortality of 6.9%. Conclusion: PSI in patients with hematologic disease, while having shorter periods to diagnosis, presents increased rates of neurologic deficit, surgical intervention, and complications.

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“…Given the high incidence of pulmonary involvement, the infection may involve the mediastinal lymph nodes, but axillary lymphadenitis has also been described [5]. Previously, mediastinal lymphadenopathy was mostly found in immunocompromised patients [6].…”

Section: Commentmentioning

confidence: 99%

Isolated Mediastinal Lymphadenopathy Caused by Rhodococcus equi Infection

Tootsi

Tamm

Laisaar

2018

The Annals of Thoracic Surgery

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Mediastinal lymphadenopathy is common finding in thoracic surgery, and it often requires morphologic confirmation to establish the definitive diagnosis. The most frequent diagnoses are metastatic lung cancer, sarcoidosis, lymphoma, tuberculosis, and other causes of granulomatous infections. Rhodococcus equi is a rare pathogen in humans that mostly affects immunocompromised patients. This report presents a case with isolated mediastinal lymphadenopathy caused by Rhodococcus equi infection in a 71-year-old immunocompetent patient.

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Disseminated Rhodococcus equi infection in a patient with Hodgkin’s lymphoma

Abstract: Since the eradication od R equi is very difficult, it is very important to make the diagnosis and initiate appropriate antibiotic therapy as soon as possible.

Cited by 5 publications

References 34 publications

Rhodococcus equi—Occurrence in Goats and Clinical Case Report

Rhodococcus equi—Occurrence in Goats and Clinical Case Report

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

Isolated Mediastinal Lymphadenopathy Caused by Rhodococcus equi Infection

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