Disseminated pulmonary histoplasmosis in immunocompetent patients: a common epidemiological exposure

Klein, Michael A.; Khan, Mirza S.; Salinas, Jorge; Sanchez, Rolando

doi:10.1136/bcr-2018-227994

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“…In addition, PCR and specific antigen test cannot be performed since there was limited technical support in our hospital. However, it is strongly suggested to perform PCR and specific antigen test in the future to further support the diagnosis of this disease [12].…”

Section: Discussionmentioning

confidence: 99%

Disseminated histoplasmosis in an immunocompetent individual diagnosed with gastrointestinal endoscopy: a case report

et al. 2019

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BackgroundHistoplasmosis is one of the invasive fungal infections and presents with symptoms mainly in the lungs. Disseminated histoplasmosis (DH) is rare and its lesions in the gastrointestinal tract are even uncommon. The concomitant involvement of the upper and lower gastrointestinal tract has never been described in the immunocompetent individuals.Case presentationA 44-year-old immunocompetent Chinese man presented with fever, hepatosplenomegaly, fungal esophagitis and protuberant lesions with central depression and erosion along the mucous membrane of the colon. The patient was diagnosed as disseminated histoplasmosis by gastrointestinal endoscopy.ConclusionsHistoplasmosis should be taken caution in patients with fever and hepatosplenomegaly. Actions should be taken to avoid its disseminated infection associated high mortality.

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Section: Discussionmentioning

confidence: 99%