Disseminated phaeohyphomycosis in a dog

Rothenburg, Lana; Snider, Timothy A.; Wilson, Allison; Confer, Anthony W.; Ramachandran, Akhilesh; Mani, Rinosh; Rizzi, Theresa E.; Nafe, Laura

doi:10.1016/j.mmcr.2017.02.003

Cited by 16 publications

(9 citation statements)

References 18 publications

(25 reference statements)

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“…In dogs, Curvularia lunata, C. geniculata or C. spicifera (syn. Bipolaris spicifera ) cause cutaneous/subcutaneous, 11‐16 osseous 17 or abdominal 18 granulomas; corneal ulceration; 19,20 or disseminated systemic disease with cutaneous, cardiac and renal involvement 21,22 . CNS involvement of Curvularia spp.…”

Section: Discussionmentioning

confidence: 99%

“…CNS involvement of Curvularia spp. has been reported in a dog with central vestibular signs and concurrent renal involvement, 23 whereas the fungus has been found in histopathological sections of the brain of a neurologically normal dog with cutaneous phaeohyphomycosis by Curvularia spicifera 22 . In cats, Curvularia lunata and C. spicifera (syn.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, the presence of a CNS‐encapsulated mass with purulent material, histopathologically characterised by lymphocytes, polymorphonuclear leukocytes and red blood cells, leads to the nomenclature of 'brain abscess' in the literature 10 . In dogs with extraneural phaeohyphomycosis by Curvularia spp., features of pyogranulomatous inflammation are evident 22 …”

Section: Discussionmentioning

confidence: 99%

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Brainstem phaeohyphomycosis due to Curvularia lunata (Cochliobolus lunatus) in a cat

et al. 2021

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A 13‐year‐old female neutered domestic short‐hair cat was presented with chronic progressive vestibular ataxia, lethargy and anorexia. Clinical examination revealed bilateral mucopurulent nasal discharge. Neurological examination revealed obtundation, a right head tilt, ambulatory tetraparesis, generalised vestibular ataxia, decreased postural reactions in all limbs, right Horner's syndrome, spontaneous conjugate jerk rotatory nystagmus and right positional ventral strabismus. Neuroanatomical localisation was observed in the right central vestibular system. Computed tomography revealed a solitary ill‐defined contrast‐enhancing mass lesion at the level of the right cerebellopontine angle. Cerebrospinal fluid (CSF) analysis revealed mild mononuclear pleocytosis and fungal elements. CSF culture was positive for Curvularia spp. Further tests for underlying diseases were all negative. The cat was treated with antibiotic and antifungal treatment, but it deteriorated rapidly and was euthanased. Necropsy of the brainstem mass lesion revealed pyogranulomatous inflammation. Panfungal polymerase chain reaction (PCR) targeting the internal transcribed spacer (ITS) region and subsequent sequencing identified Curvularia lunata in the formalin fixed brain tissue. This is the first report of brainstem phaeohyphomycosis by Curvularia lunata (Pleosporales) in a cat. In addition, this is the first report among animal and humans where fungal elements of Curvularia lunata were found in the CSF cytology. Opportunistic fungal pathogens should be always considered within the differential diagnoses list in cats with neurological signs and advanced imaging findings compatible with solitary mass lesions in the brain. In feline patients with pyogranulomatous meningoencephalitis and a suspicion of a fungal aetiology, panfungal PCR for the ITS region and sequencing should be performed regardless of the absence of fungal elements in histopathology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Brainstem phaeohyphomycosis due to Curvularia lunata (Cochliobolus lunatus) in a cat

et al. 2021

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“…This species has been increasingly recognised as an opportunistic pathogen in people with the emergence of HIV infections and increasing use of immunosuppressive drugs 14 22. In dogs, C glabrata has been mostly involved in urinary tract infections although two cases of peritonitis3 23 and disseminated infection have also been reported 2 24…”

Section: Discussionmentioning

confidence: 99%

Fungal osteomyelitis caused by Candida glabrata in a Groenendael dog

Levy¹,

Harran²,

Hammer³

et al. 2020

Vet Record Case Reports

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A four-year-old male intact Groenendael was presented for intermittent shifting lameness affecting all four limbs, lethargy, reduced appetite and weight loss of two to four weeks’ duration. Thoracic radiography revealed enlarged cranial mediastinal lymph nodes. Osteolytic lesions were identified on the spinous process of T13 and L1. Limb radiographs revealed multiple rounded, osteolytic lesions with sclerotic peripheral rim in the medullar cavity of radii, ulnas and tibias bilaterally. Fine-needle aspiration cytology of the mediastinal lymph nodes and osteolytic lesions affecting the spinous processes and histopathology of a right tibial osteolytic lesion were consistent with fungal osteomyelitis. Fungal culture performed on a right tibial biopsy grew Candida glabrata susceptible to itraconazole. Marked clinical improvement was observed following six months of itraconazole therapy. Repeated radiography revealed resolution of the bony lesions and persistence of mild cranial mediastinal lymphadenomegaly.

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“…Candida albicans and some other Candida species have been identified in urinary tract infections in cats and dogs (Pressler et al 2003, Jin andLin 2005). It was reported that, Candida glabrata (together with Fusarium oxysporum) were isolated in a patient who started with foot soles and skin lesions and continued myocardial, liver, renal interstitium in dog (Rothenburg et al 2017). In addition, Candida albicans was isolated from samples of internal organs of sepsis foals with new born necrotizing enterocolitis, renal insufficiency and incompatibility syndrome.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antifungal Activity of Some Benzothiazole Derivatives

Osmaniye¹,

Sağlık²,

Çevik³

et al. 2019

Kocatepe Veterinary Journal

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The antifungal activity of the previously synthesized compounds was evaluated in order to provide solutions to the candida-induced diseases in animals. In the present study, 10 benzothiazole derivatives (4a-4j) were resynthesized to evaluate their antifungal activity. IR, 1HNMR, 13C-NMR and HRMS (Infrared Spectroscopy, 1 H Nuclear Magnetic Resonance Spectroscopy, 13 C Nuclear Magnetic Resonance Spectroscopy, High Resolution Mass Spectrometry) spectroscopic methods, determined the structure of the synthesized compounds. MIC50(Minimum Inhibitory Concentration) values of the re-synthesized compounds against Candida species were evaluated by in vitro experiments. As a result of activity studies, it was found that compounds 4c and 4d showed significant activity. Compound 4d was found to be the most potent derivative against Candida krusei with a MIC50 value of 1.95 µg / mL.

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Disseminated phaeohyphomycosis in a dog

Cited by 16 publications

References 18 publications

Brainstem phaeohyphomycosis due to Curvularia lunata (Cochliobolus lunatus) in a cat

Brainstem phaeohyphomycosis due to Curvularia lunata (Cochliobolus lunatus) in a cat

Fungal osteomyelitis caused by Candida glabrata in a Groenendael dog

Evaluation of Antifungal Activity of Some Benzothiazole Derivatives

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