Disseminated penicilliosis (non-Penicillium marneffei) in an immuno-competent individual in Malaysia

Abstract

Penicilliosis infection caused by Penicillium marneffei is the third most common opportunistic infection in Human Immunodeficiency Virus patients in South-east Asia; however, Penicillium infection caused by non-P. marneffei is uncommon. We present a case of an immunocompetent male with disseminated penicilliosis (non-P. marneffei) presenting with recurrent empyema. The case described illustrates the challenges in managing a complicated systemic infection and the outcomes of a delayed presentation, in a potentially treatable disease.

Talaromyces (Penicillium) Species Infection in the Central Nervous System

“…Talaromycosis, caused by Talaromyces marneffei, is the third most common opportunistic infection in HIV-infected Southeast Asian patients. 1 However, it is rare to fi nd non-marneffei infection among non-HIV patients. While most cases reported in the literature describe infection in the lungs, we report an extremely rare Talaromyces species infection in the central nervous system confi rmed by CSF culture.…”