Disseminated paracoccidioidomycosis with chorioretinal involvement

Bovo, Lucas Borelli; Pierre-Filho, Paulo de Tarso P.; Carvalho, F do Carmo; Carneiro, Antonio José V.; Filho, Nelson Macchiaverni

doi:10.1038/sj.eye.6701718

Cited by 3 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bonomo et al presented the first description of the angiographic characteristics of a choroidal granuloma caused by this fungus, both the angiofluoresceinographic and fundoscopic aspects being similar to those of the present case [17]. Bovo et al presented the most recent description of retinal and choroidal involvement in systemic PCM [18]. …”

Section: Discussionsupporting

confidence: 71%

Retinal involvement of Paracoccioidomycosis: A Case Report

et al. 2012

View full text Add to dashboard Cite

Purpose: to describe the clinicopathologic features and treatment of a rare case of systemic paracoccidioidomycosis with choroidal and retinal involvement. Design: retrospective interventional case report. Participant: A 36-year-old young man with visual impairment in left eye with anterior uveitis and presence of whitish perimacular choroidal nodule, multiple underlying whitish spots and mid-periphery exudative retinal detachment. A primary extensive work-up for systemic infectious, autoimmune, neoplasic or inflammatory conditions was performed and high-resolution computer tomography scan demonstrated asymmetric parietal thickening of the trachea and bilateral diffuse multiple lobular opacities. Pulmonary bronchoscopy/biopsy of larynx, trachea and bronchial tube were also performed. Histopathological evaluation showed characteristic of Paracoccidioidomycosis. Intervention: Patient was treated with oral sulphadiazine (1.5 g/day). Main Outcome Measures: Anterior uveitis, retinal examination, histopathological evaluation and primary clinical outcome were observed during systemic treatment. Results: After 3 months of irregular treatment, choroidal lesions decreased in size forming atrophic scars and fibrotic spots; however visual acuity did not show any improvement. Conclusion: We report a rare case of systemic paracoccidioidomycosis with choroidal and retinal involvement treated with oral sulphadiazine.

show abstract

Section: Discussionsupporting

confidence: 71%

Retinal involvement of Paracoccioidomycosis: A Case Report

et al. 2012

View full text Add to dashboard Cite

show abstract

“… 11 Isolated chorioretinal involvement is infrequent, with only a few reports existing in the literature. Bovo et al described a case of multifocal chorioretinitis, which responded well to oral trimethoprim-sulfamethoxazone 160–800 mg. 8 The choroidal lesions formed atrophic scars and the subretinal fluid slowly resorbed over the course of 6 months. Bonomo et al described a case treated with amphotericin B with flattening of the chorioretinal lesion and resolution of the serous retinal detachment over 3 months.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 2 It is contracted through inhalation of the spores of Paracoccidioides brasiliensis , an organism endemic to much of South and Central America with high incidences noted in Brazil, Colombia, Argentina, and Venezuela 3 , 4 Ocular involvement is rare and most frequently involves the eyelid and conjunctiva, 5 , 6 with rare cases of choroidal granulomas and endophthalmitis. 7 , 8 , 9 , 10 We describe a case of ocular paracoccidioidomycosis presenting with a large chorioretinal lesion and describe successful treatment with serial intravitreal antifungal injections and surgical excision.…”

Section: Introductionmentioning

confidence: 99%

Chorioretinal paracoccidioidomycosis treated with intravitreal voriconazole and therapeutic vitrectomy

Oke

Loporchio

Siegel

et al. 2021

American Journal of Ophthalmology Case Reports

View full text Add to dashboard Cite

Purpose To report a case of aggressive chorioretinal paracoccidioidomycosis requiring treatment with systemic antifungal agents, frequent intravitreal voriconazole injections, and surgical excision. Observations A Brazilian man in his mid-30s with a history of chronic, biopsy-proven cutaneous paracoccidioidomycosis, chronic sinusitis, and perichondritis secondary to paracoccidioidomycosis presented with profound vision loss. He was found to have significant vitreous inflammation and a large chorioretinal lesion in the posterior pole concerning for ocular involvement. He was treated initially with combined topical and systemic steroids as well as systemic antifungals and antibiotics, then with serial intravitreal voriconazole injections resulting in a significant reduction of intraocular inflammation and subretinal fluid. The residual tractional retinal detachment from the chorioretinal lesion was addressed surgically by pars plana vitrectomy. Conclusion and importance Intravitreal voriconazole can be an effective adjuvant treatment for the vitreous inflammation and subretinal fluid associated with chorioretinal paracoccidioidomycosis. Surgical intervention may be indicated in cases complicated by tractional retinal detachment.

show abstract

“…The states of Sao Paulo, Rio de Janeiro and Minas Gerais have a higher incidence [3]. Ocular involvement is rare and, although some cases have had retinal and uveal involvement, cases normally involve the eyelid and conjunctiva [12,13].…”

Section: Introductionmentioning

confidence: 99%

Ocular Involvement as the Only Manifestation in Paracoccidioidomycosis

Freitas¹,

Godoy²,

Walters³

2022

Act Sci Oph

View full text Add to dashboard Cite

Introduction:Paracoccidioidomycosis is a systemic infection caused by Paracoccidioides Brasiliensis fungus that primarily affects the lungs. Ocular involvement is rare, in most cases having a secondary manifestation typically found in the eyelid and conjunctiva. Patient and Clinical Findings:We reported a case of paracoccidioidomycosis in a female patient with a localized ocular manifestation. Conclusions:This case shows the importance of including paracoccidioidomycosis as a differential diagnostic hypothesis in patients with only ocular manifestations that display tumors characterized by eyelid thickening.

show abstract

Disseminated paracoccidioidomycosis with chorioretinal involvement

Cited by 3 publications

References 7 publications

Retinal involvement of Paracoccioidomycosis: A Case Report

Retinal involvement of Paracoccioidomycosis: A Case Report

Chorioretinal paracoccidioidomycosis treated with intravitreal voriconazole and therapeutic vitrectomy

Ocular Involvement as the Only Manifestation in Paracoccidioidomycosis

Contact Info

Product

Resources

About