Disseminated nocardiosis due to unusual species: Two case reports

Alp, Emine; Yıldız, Orhan; Aygen, Bilgehan; Sümerkan, Bülent; Sarı, İsmail; Koc, Kemal; Couble, A.; Laurent, François; Boiron, P.; Doğanay, Mehmet

doi:10.1080/00365540500532860

Cited by 20 publications

(20 citation statements)

References 13 publications

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“…This is an important point to clarify because it would mean that, at least in the southern United States, N. cyriacigeorgica is the most important cause of nocardiosis (5). The fact that N. cyriacigeorgica has been identified in Canada (11) and now in the northeastern United States with this report suggests that N. cyriacigeorgica might actually be distributed across all of North America, in addition to Europe and Asia (1,3,7,11,17,18,22,27,35). Clearly, N. cyriacigeorgica is a species that requires closer attention, and clinical microbiology laboratories need to adapt laboratory protocols for its specific identification.…”

Section: Discussionmentioning

confidence: 99%

“…Recent reviews of collections of Nocardia clinical isolates by genotypic methods have found that a significant proportion, originally identified by routine phenotypic and chemotaxonomic methods, belong to a new species, Nocardia cyriacigeorgica (18,27,29,35). This species was first described in 2001 (38), and strains of N. cyriacigeorgica have since been recovered as the etiologic agent of human infection in Western Europe, Greece, Turkey, Japan, Thailand, and Canada (1,3,6,7,11,17,18,22,27,35,39). Most cases of infection have occurred in the context of human immunodeficiency virus-related or iatrogenic immune suppression.…”

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confidence: 99%

“…Most cases of infection have occurred in the context of human immunodeficiency virus-related or iatrogenic immune suppression. However, only a few complete clinical histories of N. cyriacigeorgica infection have been published to date (1,3,11,22).…”

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Nocardia cyriacigeorgica , an Emerging Pathogen in the United States

Salais¹,

2008

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Nocardia cyriacigeorgica is recognized as an emerging pathogen in many parts of the world. We present the first case description of invasive N. cyriacigeorgica pulmonary infection in the United States identified to the species level by 16S rRNA and hsp65 sequence analysis. A subsequent retrospective molecular screening of recent Nocardia clinical isolates at our New York City medical center yielded an additional six N. cyriacigeorgica isolates. Because routine laboratory algorithms for the phenotypic identification of Nocardia species are limited in practice, the true prevalence of N. cyriacigeorgica infections may be greater than currently appreciated. Indeed, we present evidence confirming that N. cyriacigeorgica is coincident with the unofficial species designation Nocardia asteroides complex antimicrobial susceptibility pattern type VI and distinct from the N. asteroides sensu stricto strain ATCC 19247 T . As nocardial species identity can predict antimicrobial susceptibility and guide clinical management, we offer simplified phenotypic and molecular protocols to assist the identification of N. cyriacigeorgica.

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Section: Discussionmentioning

confidence: 99%

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Nocardia cyriacigeorgica , an Emerging Pathogen in the United States

Salais¹,

2008

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“…8 In addition, isolates of N. cyriacigeorgica have been identified by 16S r RNA gene sequence analysis from patients with disseminated disease in Canada, France, Greece and The Netherlands. [9][10][11][12][13] In these paper we described a pneumonia case in which N. cyriacigeorgica is causative agent.…”

Section: A Case Of Pulmonary Nocardiosis Due Tomentioning

confidence: 99%

A Case of Pulmonary Nocardiosis Due to Nocardia cyriacigeorgica

Hazırolan¹,

Aksu²,

Baran³

et al. 2015

Turkiye Klinikleri J Case Rep

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N ocardia species belong to aerobic family Actinomycetaceae. Aerobic actinomycetes are divided into two sections such as Nocardia and other than Nocardia bacteria. Nocardia spp. are common in nature in earth and waters and they are mostly saprophytic bacteria. There are 70 known Nocardia species. More than 25 of them are describes as human isolates and many others are pathogenic in animals. A An na ah ht ta ar r K Ke el li im me el le er r: : Nokardiya enfeksiyonları; dizi analizi, DNA T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J C Ca as se e R Re ep p 2 20 01 15 5; ;2 23 3( (3 3) ): :2 27 75 5--8 8

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“…Using sequence analysis, an additional study of 121 isolates identified as "N. asteroides" from Japan and Thailand showed 27 of these isolates (22.3%) to have 16S rRNA gene sequences identical to that of the type strain of N. cyriacigeorgica. In addition, isolates of N. cyriacigeorgica have been identified by 16S rRNA gene sequence analysis from patients with disseminated disease in Canada, France, Greece, The Netherlands, and Turkey (1,2,11,14,21).…”

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confidence: 99%