Disseminated Nocardiosis: A Rare Infectious Complication Following Non–Heart-Beating Donor Liver Transplantation

Marchan, S. Jimenez-Galanes; Díaz, Juan Carlos Meneu; Maestro, Óscar Caso; Saborido, B. Perez; Elola-Olaso, A. Moreno; Usera, M. Abradelo de; Suárez, Y. Fundora; Calvo, Amelia Serraller; Molinero, V.; Reyne, Ana García; Valencia, V. Barra; Juan, Rafael San; González, Esther

doi:10.1016/j.transproceed.2009.05.011

Cited by 14 publications

(7 citation statements)

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“…Due to the poor prognosis with a mortality of 15% in cases with delayed diagnosis, an early start of effective therapy is urgently required. Nocardia infections were recently observed in CHC liver transplant patients under immunosuppressive regimens [ 8 , 9 ]. Therefore, it is tempting to speculate that in this case antiviral treatment-induced neutropenia may have favored the manifestation of Nocardia infection.…”

Section: Discussionmentioning

confidence: 99%

Pleuro-Pulmonary Nocardiosis as Opportunistic Infection in a Patient with Chronic Hepatitis C under Combination Treatment with Pegylated Interferon, Ribavirin, and Boceprevir

Putz-Bankuti

Kessler

Valentin

et al. 2013

Case Reports in Hepatology

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Section: Discussionmentioning

confidence: 99%

Pleuro-Pulmonary Nocardiosis as Opportunistic Infection in a Patient with Chronic Hepatitis C under Combination Treatment with Pegylated Interferon, Ribavirin, and Boceprevir

Putz-Bankuti

Kessler

Valentin

et al. 2013

Case Reports in Hepatology

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“…Cephalosporins, carbepenems, fluoroquinolones, linezolid and doxycycline had been documented used to treat nocardiosis [ 1 , 9 , 11 , 12 ]. The treatment is usually continued for 3–12 months [ 9 , 13 ], but in this case we achieved remission, and free of recurrence at least at 12 months of follow up, by only using 3 week course of imipenem and levofloxacin, which was the one of the shortest course of antibiotics used in any of the studies. This may have been possible because of early surgical intervention which was highly successful, due to the favorable site of the lesions.…”

Section: Discussionmentioning

confidence: 99%

"Primary" nocardial brain abscess in a renal transplant patient

et al. 2015

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BackgroundIntracranial abscesses are rare among transplant recipients, and Nocardia is responsible for less than 2 % of them. Nocardiosis, a chronic infection and is difficult to treat. Primary infection involves lungs and eventually disseminates. Primary nocardial abscesses are rare and we report a case from Sri Lanka.Case presentationA 38 year old Sri Lankan, who has received his 2nd ABO matched live donor transplantation, which was complicated with perinephric hematoma and massive transfusion syndrome. He presented with fever, worsening headache and papilledema. An urgent magnetic resonance image (MRI) showed an occipital abscess with midline shift. Craniotomy and drainage followed by 3 week course of imipenem and levofloxacin, which rendered him symptom free. After 12 months he has stayed recurrence free. Imaging and bacteriology of the respiratory tract failed to demonstrate Nocardia infection.ConclusionIsolated (Primary) nocardial brain abscess are rare, and have an excellent response to medical therapy. We achieved a good response from a relatively short course of antibiotics (not using sulfonamides, due to allergy), where long courses of antibiotic had been the norm.

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“…Nocardiosis may complicate liver transplantation [136][137][138] but is rare: an incidence of 0.1% (2/1,840) was noted in Pittsburgh (1985-2005) 54 ; 0.18% (3/1,654) in Valencia, Spain from 1980 to 2010 122 ; 0.3% (1/736) at Duke University from 1996 to 2103 128 ; and 3.7% (7/191) in London. 139 The median time to diagnosis of nocardiosis is typically late (often >1 year posttransplant).…”

Section: Liver Transplant Recipientsmentioning

confidence: 99%

Nocardia spp.: A Rare Cause of Pneumonia Globally

Lynch

Reid

Clark

2020

Semin Respir Crit Care Med

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AbstractMembers of the Nocardia genus are ubiquitous in the environment. These aerobic, gram-positive organisms can lead to life-threatening infection, typically in immunocompromised hosts such as solid organ transplant recipients or those receiving immunosuppressive medications for other reasons. This current review discusses the microbiology of nocardiosis, risk factors for infection, clinical manifestations, methods for diagnosis, and treatment. Nocardiosis primarily affects the lung but may also cause skin and soft tissue infection, cerebral abscess, bloodstream infection, or infection involving other organs. Although rare as a cause of community-acquired pneumonia, Nocardia can have severe morbidity and mortality, particularly in patients with comorbidities or compromised immunity. Early diagnosis and timely initiation of therapy are critical to optimizing patient outcomes. Species identification is important in determining treatment, as is in vitro susceptibility testing. Sulfonamide therapy is usually indicated, although a variety of other antimicrobials may be useful, depending on the species and susceptibility testing. Prolonged therapy is usually indicated, for 6 to 12 months, and in some cases surgical debridement may be required to resolve infection.

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Disseminated Nocardiosis: A Rare Infectious Complication Following Non–Heart-Beating Donor Liver Transplantation

Cited by 14 publications

References 4 publications

Pleuro-Pulmonary Nocardiosis as Opportunistic Infection in a Patient with Chronic Hepatitis C under Combination Treatment with Pegylated Interferon, Ribavirin, and Boceprevir

Pleuro-Pulmonary Nocardiosis as Opportunistic Infection in a Patient with Chronic Hepatitis C under Combination Treatment with Pegylated Interferon, Ribavirin, and Boceprevir

"Primary" nocardial brain abscess in a renal transplant patient

Nocardia spp.: A Rare Cause of Pneumonia Globally

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