Disseminated Nannizziopsis Infection in an Adolescent With a STAT1 Mutation

Abstract

An adolescent with failure to thrive developed cuboid bone osteomyelitis and brain abscesses. Mold isolated from both locations was identified by universal genetic sequencing as Nannizziopsis spp, which is typically a pathogen of reptiles. The patient was subsequently diagnosed with a STAT1 mutation and was successfully treated.

Uncommon fungal pyomyositis in a kidney transplant recipient

“…Nannizziopsis obscura is a very rare but emerging fungus in immunocompromised patients from Sub‐Saharan West Africa, 1,2 originally known and studied in reptiles 3 . So far, reported cases of human Nannizziopsis infection involve cutaneous/subcutaneous tissue, lungs, liver, bone/joints, or the central nervous system 1,2,4–6 . Nanizziopsis can be easily misdiagnosed as more common fungal pathogens such as keratinophile species, as it shares the same mycological morphological characteristics as species like Trichophyton, Trichosporon , Geotrichum, or Chrysosporium sp.…”