Disseminated mycobacterium kansasii presenting with skin lesions in a patient with chronic lymphocytic leukemia

Tempero, Margaret A.; Smith, Philip W.

doi:10.1002/mpo.2950090313

Cited by 9 publications

(4 citation statements)

References 21 publications

(1 reference statement)

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“…Eight cases of disseminated skin infection were identified among 1735 previous studies of M. kansasii disease reported from 1956 to February 2017 in the PubMed database (Fraser et al, 1975;Hirsh and Saffold, 1976;Tempero and Smith, 1981;Kramers et al, 1992;Mandal et al, 1992;Kotb et al, 2001;Nomura et al, 2009;Han et al, 2010). The case presented herein is the second case of disseminated M. kansasii disease involving the skin in a previously healthy patient, with the first case reported in 2001 (Kotb et al, 2001).…”

Section: Discussionmentioning

confidence: 85%

Disseminated Mycobacterium kansasii infection with cutaneous lesions in an immunocompetent patient

Zhang

Feng

2017

International Journal of Infectious Diseases

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A case of disseminated Mycobacterium kansasii infection involving the skin and soft tissue in a 57-year-old male farmer who presented with recurrent fever, respiratory syndromes, and skin lesions is reported. The positive findings of syndromes, laboratory examinations, and identification of M. kansasii in puncture fluid indicated the diagnosis of disseminated M. kansasii infection involving the skin and soft tissue, lungs, and mediastinal lymph nodes. After applying the standard HRE regimen (isoniazid 300mg/day, rifampicin 600mg/day, and ethambutol 750mg/day), the patient's temperature normalized and his symptoms improved gradually. No notable adverse drug reactions occurred and the skin lesions had healed after 4 months of follow-up. Disseminated M. kansasii infections occur mainly in immunocompromised patients. Moreover, disseminated infections with skin lesions is rare in immunocompetent patients. Following a review of the literature, only eight similar cases were identified as of disseminated M. kansasii infection with cutaneous lesions, and thecase presented here appears to be the second involving an immunocompetent individual. Special attention should be paid to a persistent and chronic rash following a chronic respiratory syndrome in order to exclude skin disease caused by non-tuberculous mycobacteria.

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Section: Discussionmentioning

confidence: 85%

Disseminated Mycobacterium kansasii infection with cutaneous lesions in an immunocompetent patient

Zhang

Feng

2017

International Journal of Infectious Diseases

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“…Hilar or mediastinal lymphadenopathies have been found in only 8% of patients with M. kansasii lung disease, and the most common pulmonary radiographic findings are nodules and consolidation [6]. There have been several case reports of M. kansasii infection in hematologic patients; 6 cases in hairy cell leukemia patients, 1 in a chronic myelogenous leukemia patient, 1 in chronic lymphocytic leukemia patient, 1 in a follicular lymphoma patient, and 1 in a hemophagocytic syndrome patient [13141516]. Of these 10 cases, 6 cases were disseminated infection with lung involvement, 2 cases were pneumonia, and 2 cases were skin infection [13141516].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium kansasiiPneumonia with Mediastinal Lymphadenitis in a Patient with Acute Myeloid Leukemia: Successful Treatment to Stem Cell Transplantation

et al. 2017

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Non-tuberculous mycobacterial (NTM) disease is a relatively rare cause of neutropenic fever in patients with hematologic malignancies. During the neutropenic period, performing invasive procedures for microbiological or pathological confirmation is difficult. In addition, the optimal treatment duration for NTM disease in patients with leukemia, especially prior to stem cell transplantation (SCT), has not been documented. Therefore, we report a case of pneumonia with necrotizing lymphadenitis caused by Mycobacterium kansasii diagnosed during chemotherapy being performed for acute myeloid leukemia. The radiologic findings were similar to those of invasive fungal pneumonia; however, a bronchoalveolar washing fluid culture confirmed that the pathogen was M. kansasii. After 70 days from starting NTM treatment, allogeneic SCT was performed without any complications. The patient fully recovered after 12 months of NTM treatment, and neither reactivation of M. kansasii infection nor related complications were reported.

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“…Cutaneous infection by M. kansasii is rare. To our knowledge, 45 patients have been described, with ages ranging from 16 to 84 years (6–33). In 72% of those cases, an immunologic disorder resulting from chemotherapy, autoimmune disease, AIDS, renal or cardiac transplantation, or other predisposing factors (14) was identified.…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous M. kansasii infections are rare. The first case was described by Mayberry et al (6) in 1965, and an additional 44 cases have been reported since then (7–33). Furthermore, none of these patients with cutaneous M. kansasii infection were children.…”

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confidence: 99%

Primary Cutaneous Mycobacterium kansasii Infection in a Child

Chaves

Torrelo²,

Mediero³

et al. 2001

Pediatric Dermatology

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Disseminated mycobacterium kansasii presenting with skin lesions in a patient with chronic lymphocytic leukemia

Cited by 9 publications

References 21 publications

Disseminated Mycobacterium kansasii infection with cutaneous lesions in an immunocompetent patient

Disseminated Mycobacterium kansasii infection with cutaneous lesions in an immunocompetent patient

Mycobacterium kansasiiPneumonia with Mediastinal Lymphadenitis in a Patient with Acute Myeloid Leukemia: Successful Treatment to Stem Cell Transplantation

Primary Cutaneous Mycobacterium kansasii Infection in a Child

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