Disseminated Mycobacterium avium complex infection in an immunocompetent pregnant woman

Song, Joon Young; Park, Cheong Won; Kee, Sae Yoon; Choi, Won Seok; Kang, Eun Young; Cheong, Hee Jin

doi:10.1186/1471-2334-6-154

Cited by 15 publications

(10 citation statements)

References 17 publications

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“…In contrast, MAH is considered a pathogenic species belonging to the Mycobacterium avium complex, frequently causing respiratory illness in immunocompromised patients [26,27]. In addition, cases of M. avium infections in immunocompetent patients do occur regularly and are increasing [28,29,30]. MAH is able to invade macrophages and inhibits intracellular killing to ensure its survival and replication [1].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium smegmatis But Not Mycobacterium avium subsp. hominissuis Causes Increased Expression of the Long Non-Coding RNA MEG3 in THP-1-Derived Human Macrophages and Associated Decrease of TGF-β

et al. 2019

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Pathogenic mycobacteria are able to persist intracellularly in macrophages, whereas non-pathogenic mycobacteria are effectively combated and eliminated after their phagocytosis. It is known that TGF-β plays an important role in this context. Infection with pathogenic mycobacteria such as Mycobacterium tuberculosis or M. avium leads to production of active TGF-β, which blocks the ability of IFN-γ and TNF-α to inhibit intracellular replication. On the other hand, it is known that the long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) is involved in the regulation of TGF-β. In this study, we show how the infection of THP-1-derived human macrophages with the saprophytic M. smegmatis but not with the facultatively pathogenic M. avium subsp. hominissuis leads to increased MEG3 expression. This is associated with the downregulation of DNA methyltransferases (DNMT) 1 and 3b, which are known to regulate MEG3 expression via promoter hypermethylation. Consequently, we observe a significant downregulation of TGF-β in M. smegmatis-infected macrophages but not in M. avium subsp. hominissuis pointing to lncRNAs as novel mediators of host cell response during mycobacterial infections.

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Section: Discussionmentioning

confidence: 99%

Mycobacterium smegmatis But Not Mycobacterium avium subsp. hominissuis Causes Increased Expression of the Long Non-Coding RNA MEG3 in THP-1-Derived Human Macrophages and Associated Decrease of TGF-β

et al. 2019

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“…A case report from Korea described a 26-year-old immunocompetent pregnant woman who presented with fever and general malaise and was found to have MAC isolated from the sputum and placenta 4. However, it was concluded that disseminated infection in this case might be related to pregnancy, as there are alterations of the immune status in pregnant women which lead to impaired cell-mediated immunity.…”

Section: Discussionmentioning

confidence: 84%

An opportune finding in suspected liver metastases

Hurley

Turner²,

Campbell³

et al. 2011

Case Reports

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Opportunistic mycobacterial infections are rare in immunocompetent patients. The authors describe a case of disseminated Mycobacterium avium complex disease in a previously healthy patient presenting with hepatosplenomegaly and non-specific symptoms which initially led to a diagnosis of metastatic carcinoma. After correct treatment she made a full recovery, with resolution of symptoms and the radiological findings.

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“…Cases of disseminated tuberculosis in pregnancy in non-immune-compromised women have rarely been published and none after in vitro fertilisation for as far as we were able to find. [1][2][3][4][5][6][7][8][9][10] A chest radiograph does not have to be done during routine study of infertility. Learning points ▸ Clinicians should be alert for tuberculosis also in women that have lived in endemic areas in the past but have moved to the West since several years.…”

Section: Discussionmentioning

confidence: 99%

Disseminated tuberculosis in pregnancy unknown to doctors in Western Europe case presentation: ‘part of the routine study in infertility’

Jacquemyn¹,

Casteren²,

Luijks³

et al. 2012

BMJ Case Reports

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Tuberculosis in pregnancy is possibly increasing in Western Europe due to a higher incidence in immigrant women from endemic regions. Common in recent immigrants. Diagnosis during pregnancy is delayed because the disease is more frequently extra-pulmonary with few symptoms and western doctors are no longer familiar with signs and symptoms of tuberculosis. We report the case of a 28-year-old woman presenting in the 13th week of pregnancy with vaginal bleeding, respiratory symptoms including persistent coughing and fever since 1 month. Diagnosis was delayed because of doubts on taking x-rays during pregnancy, and only 6 days after admission chest x-ray and blood-cultures led to diagnose miliary tuberculosis. Despite tuberculostatic medication expulsion of an infected fetus and placenta occurred. Histological examination of the placenta confirmed tuberculosis in the placental tissue.

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Disseminated Mycobacterium avium complex infection in an immunocompetent pregnant woman

Abstract: Background: Disseminated mycobacterium avium complex (MAC) occurs mainly in immunocompromised hosts, which is associated with abnormal cellular immunity.

Cited by 15 publications

References 17 publications

Mycobacterium smegmatis But Not Mycobacterium avium subsp. hominissuis Causes Increased Expression of the Long Non-Coding RNA MEG3 in THP-1-Derived Human Macrophages and Associated Decrease of TGF-β

Mycobacterium smegmatis But Not Mycobacterium avium subsp. hominissuis Causes Increased Expression of the Long Non-Coding RNA MEG3 in THP-1-Derived Human Macrophages and Associated Decrease of TGF-β

An opportune finding in suspected liver metastases

Disseminated tuberculosis in pregnancy unknown to doctors in Western Europe case presentation: ‘part of the routine study in infertility’

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