Disseminated Mycobacterium abscessus subspecies massiliense infection and subsequent prosthetic joint infection in a hemodialysis patient: A case report

Management of M. abscessus subsp. abscessus early-onset prosthetic joint infection: Case report and literature review

“…Prosthesis removal has been associated with a favorable outcome at 6–12 months, and in NTM PJI is required in almost 90% of cases, but the optimal surgical strategy for the treatment of RGM PJI has yet to be defined [5] , [24] . As reported in Table 1 [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] 14 of 17 (82 %) successfully treated MABC PJI cases required a 2-stage revision arthroplasty, one patient [8] underwent hemipelvectomy and one [13] underwent arthrodesis. Only one patient [17] was successfully treated with debridement, antibiotics and implant retention (DAIR).…”

“…As reported in Table 1 [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] 14 of 17 (82 %) successfully treated MABC PJI cases required a 2-stage revision arthroplasty, one patient [8] underwent hemipelvectomy and one [13] underwent arthrodesis. Only one patient [17] was successfully treated with debridement, antibiotics and implant retention (DAIR). Our patient underwent a revision surgery, with debridement and spacer renewal, approximately one week after the start of targeted therapy.…”

“…There is a high grade of variability in the number of molecules and duration of therapy used to treat MABC PJI. As reported in Table 1 [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] in all but two [10] , [19] cases of successfully treated MABC PJI, a multidrug regimen containing at least 3 molecules was used, at least for the intensive phase. The mean duration of antimycobacterial therapy of successfully treated MABC PJI was 39 ± 23 weeks.…”

“…REA. Reimplantation at 11 months 6 months No relapse Tsuruyama Y et al [17] 74/male M. abscessus subsp. massiliense Knee IMP + AMK (5) IMP + AMK + AZM (25) IMP + AMK + AZM (not reported) AMK + AZM (not reported) Multiple arthrocentesis 6 months No relapse Genovese N et al [18] 79/male M. abscessus subsp.…”

“…bolletii [6] . To our knowledge, 17 cases of MABC PJI are reported in the literature, of which only 1 is from M. abscessus [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] ( Table 1 ). There is no standardized treatment or strength recommendation correlating in vitro RGM susceptibility and clinical response [23] .…”