Disseminated &lt;i&gt;Mycobacterium chelonae&lt;/i&gt; Infection, Including Discitis

Watanabe, Yusuke; Fujita, Hiroaki; Fukushima, Shinji; Nakamura, Itaru

doi:10.2169/internalmedicine.8539-21

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…The results of susceptibility testing ( Franco-Paredes et al, 2018 ; Uslu et al, 2019 ; Watanabe et al, 2022 ) indicated that M. chelonae is often susceptible to macrolides, cefoxitin, fluoroquinolones, and tobramycin. The monotherapy (clarithromycin) can be sufficient for localized or superficial infections but not enough for patients who develop potential resistance.…”

Section: Main Textmentioning

confidence: 99%

Treatment of non-tuberculosis mycobacteria skin infections

Wang,

Jia,

2023

Front. Pharmacol.

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Non-tuberculosis mycobacteria (NTM) skin infections have become increasingly prevalent in recent years, presenting a unique challenge in clinical management. This review explored the complexities of NTM infections localized to the superficial tissues and provided valuable insights into the optimal therapeutic strategies. The antibiotic selection should base on NTM species and their susceptibility profiles. It is recommended to adopt a comprehensive approach that considers the unique characteristics of superficial tissues to improve treatment effectiveness and reduce the incidence of adverse reactions, infection recurrence, and treatment failure. Infection control measures, patient education, and close monitoring should complement the treatment strategies to achieve favorable outcomes in managing NTM skin infections. Further efforts are warranted to elucidate factors and mechanisms contributing to treatment resistance and relapse. Future research should focus on exploring novel treatment options, innovative drug development/delivery platforms, and precise methodologies for determining therapeutic duration. Longitudinal studies are also needed to assess the long-term safety profiles of the integrated approaches.

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Section: Main Textmentioning

confidence: 99%

Treatment of non-tuberculosis mycobacteria skin infections

Wang,

Jia,

2023

Front. Pharmacol.

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Mycobacterium marseillense bloodstream infection combined with skin fungal infection: a case report and literature review

Wang,

Xue,

Chen

et al. 2024

BMC Infect Dis

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Background Non-tuberculous mycobacteria (NTM) are present widely in the natural environment and can invade the human body through the respiratory tract, gastrointestinal tract, and skin. Immunocompromised patients are particularly prone to infection, which primarily affects multiple organs, including the lungs, lymph nodes, and skin. However, cases of NTM bloodstream infections are rare. Here, we report a rare case of Mycobacterium marseillense bloodstream infection with concurrent skin fungal infection in a patient after kidney transplantation. Related literature was reviewed to enhance the understanding of this rare condition.Case presentation A 58-year-old male with a history of long-term steroid and immunosuppressant use after kidney transplantation presented with limb swelling that worsened over the past two months. Physical examination revealed redness and swelling of the skin in all four limbs, with a non-healing wound on the lower left limb. Skin tissue analysis by metagenomic next-generation sequencing (mNGS) and fungal culture indicated infection with Trichophyton rubrum. Blood culture results suggested infection with Mycobacterium marseillense. After receiving anti-NTM treatment, the patient's symptoms significantly improved, and he is currently undergoing treatment. ConclusionMycobacterium marseillense is a NTM. Gram staining suffered from misdetection, and the acid-fast staining result was positive. This bacterium was identified by mass spectrometry and mNGS analyses. Antimicrobial susceptibility tests for NTM were performed using the broth microdilution method. The results of the susceptibility test showed that Mycobacterium marseillense was sensitive to clarithromycin, an intermediary between moxifloxacin and linezolid. Bacterial clearance requires a combination of drugs and an adequate course of treatment. NTM bloodstream infections are relatively rare, and early identification and proactive intervention are key to their successful management.

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Mycobacterium maeseillense bloodstream infection combined with skin fungal infection: a case report and literature review

Wang,

Xue,

Chen

et al. 2024

Preprint

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Background Non-tuberculous mycobacteria (NTM) are widely present in the natural environment and can invade the human body through the respiratory tract, gastrointestinal tract, and skin. They are particularly prone to infecting immunocompromised patients, primarily affecting multiple organs including the lungs, lymph nodes, and skin. However, reported cases of NTM bloodstream infections are rare. We aim to report a rare case of Mycobacterium massiliense bloodstream infection with concurrent skin fungal infection in a patient after kidney transplantation. We also provide a literature review to enhance understanding of this uncommon condition. Case presentation A 58-year-old male with a history of long-term steroid and immunosuppressant use after kidney transplantation presented with limb swelling for three years, which worsened over the past two months. Physical examination revealed redness and swelling of the skin on all four limbs, with a non-healing wound on the lower left limb. Skin tissue analysis using metagenomic next-generation sequencing (mNGS) and fungal culture indicated infection with red-colored trichophyton rubrum. Blood culture suggested infection with Mycobacterium massiliense. After receiving anti-NTM treatment, the patient’s symptoms have significantly improved and they are currently still undergoing treatment. Conclusion Mycobacterium maeseillense belongs to NTM. Gram staining is prone to miss detection and acid-fast staining was positive. This bacterium could be identified by mass spectrometry and mNGS. The drug sensitivity test of NTM was performed by broth microdilution method. The results of the susceptibility test showed that Mycobacterium maeseillense was sensitive to clarithromycin, intermediary to moxifloxacin and linezolid. The bacteria needs a combination of drugs and an adequate course of medication. NTM bloodstream infections are relatively rare, and early identification and proactive intervention are key to successful management.

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Disseminated <i>Mycobacterium chelonae</i> Infection, Including Discitis

Cited by 4 publications

References 2 publications

Treatment of non-tuberculosis mycobacteria skin infections

Treatment of non-tuberculosis mycobacteria skin infections

Mycobacterium marseillense bloodstream infection combined with skin fungal infection: a case report and literature review

Mycobacterium maeseillense bloodstream infection combined with skin fungal infection: a case report and literature review

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