Disseminated Intravascular Coagulopathy Is Associated with the Outcome of Persistent Inflammation, Immunosuppression and Catabolism Syndrome

Nakamura, Kensuke; Ogura, Kentaro; Nakano, Hidehiko; Naraba, Hiromu; Takahashi, Yūji; Sonoo, Tomohiro; Hashimoto, Hideki; Goto, Tadahiro

doi:10.3390/jcm9082662

Cited by 14 publications

(22 citation statements)

References 24 publications

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“…Nakamura et al reported that age, sex, sepsis, albumin level, lymphocyte count, Hb and HbA1c levels, Cr level, and overt DIC were signi cantly associated with PIICS [5]. Thus, the results of the present study are consistent with their ndings.…”

Section: Discussionsupporting

confidence: 92%

“…To analyze the factors related to the onset of PIICS, univariate analysis was performed with PIICS as the objective variable and with each of the following factors as explanatory variables: patient pro le (age, sex, height, and weight); factors involved in the diagnosis of PIICS (CRP and albumin levels and lymphocyte count); factors reported as potential risk factors in previous studies (sepsis; Cr, Hb, and HbA1c levels, overt DIC, and APACHE II score) [5]; history of steroid use; and blood transfusion (RBC, FFP, PLT). Next, a multivariate logistic regression analysis was performed with PIICS as the objective variable and all the above variables as explanatory variables.…”

Section: Discussionmentioning

confidence: 99%

“…Patients who required hospitalization for > 15 days and met the criteria of CRP > 3.0 mg/dL or albumin < 3.0 mg/dL or lymph < 800/µL on day 14 were assigned to the PIICS group [4,5]. Patients who required hospitalization for > 15 days and did not meet the PIICS criteria were assigned to the non-PIICS group.…”

Section: De Nition Of Piicsmentioning

confidence: 99%

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Association of Red Blood Cell and Platelet Transfusions With Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Critically Ill Patients

Suzuki

Ichibayashi

Masuyama

et al. 2021

Preprint

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The objective of this single-center retrospective cohort study was to investigate the relationship between blood transfusion and persistent inflammation, immunosuppression, and catabolism syndrome (PIICS). The study was conducted at the Critical Care Center at Toho University Omori Medical Center, Japan. We included 391 patients in the PIICS group (hospitalization for > 15 days, C-reactive protein > 3.0 mg/dL or albumin < 3.0 mg/dL or lymph < 800/µL on day 14) and 762 patients in the non-PIICS group (hospitalization for > 15 days and not meeting the PIICS criteria). We performed univariate and multivariate logistic regression analyses using PIICS as the objective variable and red blood cell (RBC) or fresh frozen plasma or platelet (PLT) transfusion and other confounding factors as explanatory variables. In addition, we conducted sensitivity analysis using propensity score matching analysis. The multivariate and propensity score analyses showed that RBC and PLT transfusions were significantly associated with PIICS. This is the first study to report an association between RBC and PLT transfusions and PIICS. Our findings have contributed to better understanding the risk factors of PIICS and suggest that physicians should consider the risk of PIICS occurrence when administering blood transfusions in intensive care unit (ICU) patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Association of Red Blood Cell and Platelet Transfusions With Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Critically Ill Patients

Suzuki

Ichibayashi

Masuyama

et al. 2021

Preprint

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“…Some patients experience chronic inflammation, which is also known as persistent inflammation, immunosuppression, and catabolism syndrome [ 90 ]. This condition may be caused by various conditions including disseminated intravascular coagulopathy [ 91 ] and electrolyte imbalance [ 92 ]. Chronic inflammation is known to cause muscle atrophy [ 93 ].…”

Section: Picsmentioning

confidence: 99%

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Nakanishi

Tsutsumi

Hara

et al. 2021

JCM

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Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

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“…Some patients experience chronic inflammation, which is called the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome [71]. This condition may be caused by various conditions including disseminated intravascular coagulopathy [72] and electrolyte imbalance [73]. Chronic inflammation is known to cause muscle atrophy [74].…”

Section: Picsmentioning

confidence: 99%

Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Nakanishi¹,

Tsutsumi²,

Hara³

et al. 2020

Preprint

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Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interplays the contraction of actin-containing thin filaments and myosin-containing thick filaments. The breakdown product of titin has been measurable in urine as urinary titin N-fragments. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

show abstract

Disseminated Intravascular Coagulopathy Is Associated with the Outcome of Persistent Inflammation, Immunosuppression and Catabolism Syndrome

Cited by 14 publications

References 24 publications

Association of Red Blood Cell and Platelet Transfusions With Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Critically Ill Patients

Association of Red Blood Cell and Platelet Transfusions With Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Critically Ill Patients

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

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