Disseminated Intravascular Coagulation Syndromes

Hardaway, Robert M.

doi:10.1001/archsurg.1961.01300180042009

Cited by 55 publications

(46 citation statements)

References 18 publications

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“…aetiology of disease (Hardaway, 1966). In late pregnancy certain syndromes occur where intravascular fibrin deposition appears to be a feature and the inhibition of fibrinolytic activity may therefore be an important aetiological factor.…”

Section: Resultsmentioning

confidence: 99%

Fibrinolytic Enzyme System and Pregnancy

Bonnar¹,

McNicol²,

Douglas³

1969

BMJ

145

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Smmary: The effect of pregnancy on the components of the fibrinolytic enzyme system was determined by serial observations on 10 healthy women during normal pregnancy, labour, and the puerperium. The The haemostatic mechanism in pregnancy appears to be altered towards an enhanced capacity to form fibrin and a diminished ability to lyse fibrin. These changes may be a physiological development to ensure the integrity of the foetal and maternal circulations and provide rapid and effective haemostasis in the uterus during and after placental separation. Nevertheless, the changes may also establish a vulnerable state for intravascular fibrin deposition. Introduction The fibrinolytic enzyme system or plasminogen-plasmin system has a physiological role complementary to the coagulation mechanism in maintaining the patency of the blood vessels by promoting the removal of intravascular fibrin. The behaviour of the fibrinolytic mechanism in human pregnancy is therefore of special interest because an increase in the concentration of certain coagulation factors, particularly fibrinogen, is known to occur as pregnancy advances. Fibrinolytic activity has been reported to be decreased in late pregnancy, but many of the previous reports are single observations obtained under varying conditions and conflicting results have been presented. The purpose of this investigation was to elucidate the changes in the components of the fibrinolytic enzyme system induced by pregnancy and parturition by serial observations on a group of healthy women followed throughout normal pregnancy, labour, and the puerperium.According to current concepts the coagulation and fibrinolytic systems may be in a state of dynamic equilibrium which keeps the vascular compartment intact and patent, the coagulation system laying down fibrin on the vascular endothelium to seal any gaps which may occur, and the fibrinolytic system removing such fibrinous deposits after they have served their

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Section: Resultsmentioning

confidence: 99%

Fibrinolytic Enzyme System and Pregnancy

Bonnar¹,

McNicol²,

Douglas³

1969

BMJ

145

View full text Add to dashboard Cite

show abstract

“…it is unlikely that bradykinin is involved (7,8). Other explanations for the beneficial effects of the drugs tested in shock may include prevention of disseminated intravascular coagulation (9), stabilizing lysosomal membranes (10), blocking the aggregation of platelets (11) or interfering with the reactions of the complement system (12).…”

Section: Discussionmentioning

confidence: 99%

Effects of Anti-inflammatory Drugs in Shock Caused by Injection of Living E. coli Cells

Culp

Erdös

Hinshaw

et al. 1971

Experimental Biology and Medicine

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“…Though the microthrombi are not always easy to find as they soon disappear, probably being lysed by endogenous fibrinolysin and then washed out. On the other hand, these changes are not merely 'agonal', as they are frequently seen in association with cellular infiltration and small areas of necrosis, and are never found in cases of trauma resulting in immediate death (Hardaway, 1966).…”

Section: Resultsmentioning

confidence: 98%

“…Microthrombi were found in sections from lungs, liver, kidneys, and also from badly traumatized muscles. These features represent an episode of DIC, well recognized in connexion with severe stress syndromes, including traumatic and haemorrhagic shock (Hardaway, 1966 during the first week after birth are shown in Table VI. The most frequent damage was skin bruising in the gluteal region, usually unilateral, and oedema of external genitalia.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, babies with severe muscle trauma resulting in stagnant capillary circulation, acidosis, and myolytic and haemolytic products accumulated in crushed tissues provide all the conditions necessary for development of DIC (Hardaway and Johnson, 1963;Hardaway, 1966; R. M. Hardaway, personal communication, 1970). Leissring and Vorlick5 (1968) reported a case of a newborn baby with asphyxia, brain damage, and haemorrhagic diathesis, in whom post-mortem microscopical examination revealed typical features of DIC.…”

Section: Resultsmentioning

confidence: 99%

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