Disseminated intravascular coagulation following cranial trauma

Clark, Jerrold A.; Finelli, Robert E.; Netsky, Martin G.

doi:10.3171/jns.1980.52.2.0266

Cited by 47 publications

(13 citation statements)

References 23 publications

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“…A related case associated with trauma was reported by Clark et al [23]. A 78-year-old man fell off a 20-foot ladder and hit his head.…”

Section: Discussionmentioning

confidence: 97%

Diffuse Intravascular Coagulation Associated with Brain Tumor Surgery in Children

Huang¹,

Koo²

1990

Pediatr Neurosurg

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There have been numerous reported cases of diffuse intravascular coagulation (DIC) or defibrination syndrome associated with head trauma, but very few reported cases associated with primary brain tumor. This report concerns the findings in a case of DIC associated with brain tumor surgery in an infant. The patient died 2 days after surgery from acute renal and respiratory failure as a result of postoperative DIC. Therapy for DIC is controversial and shows mixed results.

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“…A related case associated with trauma was reported by Clark et al [23]. A 78-year-old man fell off a 20-foot ladder and hit his head.…”

Section: Discussionmentioning

confidence: 97%

Diffuse Intravascular Coagulation Associated with Brain Tumor Surgery in Children

Huang¹,

Koo²

1990

Pediatr Neurosurg

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“…Furthermore, although the association between coagulopathy and the severity of head injury and clinical outcome has been reported among adults [6, 7, 8, 9, 10], it has not been extensively studied among children. Nonetheless, two published studies do suggest that coagulopathy can be a serious complication among children with head injury [1, 11].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical manifestation of posttraumatic coagulopathy ranges from discrete abnormalities of hemostasis to very severe disorders, such as hyperfibrinolysis and disseminated intravascular coagulation (DIC). The severity of head injury and DIC are associated with increased mortality, with DIC provoking hemorrhagic and/or thrombotic damage of the central nervous system, lungs, liver and spleen [6, 7, 8, 9]. …”

Section: Introductionmentioning

confidence: 99%

The Influence of Hemocoagulative Disorders on the Outcome of Children with Head Injury

et al. 2001

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Background: Although disseminated intravascular coagulation (DIC) and other hemocoagulative abnormalities are severe complications of head injury, their effect on clinical outcome remains unclear, particularly among children. Objectives: To evaluate the frequency of hemocoagulative abnormalities and their influence on outcome among children with head injury. Study Design: We conducted a prospective observational study among 60 children with head injury, immediately evaluating severity of head injury (Glasgow Coma Scale, GCS); cerebral axial tomography; prothrombin time; activated partial thromboplastin time (aPTT); fibrinogen level; concentration of fibrin-fibrinogen degradation products (FDP), and platelet count. Two months after injury, we applied the Glasgow Outcome Score (GOS). Associations with GOS were evaluated using univariate and multivariate logistic models. Results: Among children with severe head injury, 22.2% (6/27) developed DIC, all of whom died and had shown severe brain edema. Among those with severe head injury yet without DIC, the mortality was only 14.2%. A low GOS was significantly and independently associated with a low GCS, multiple trauma, delayed aPTT, low fibrinogen level, elevated FDP and low platelet count. Brain edema was also associated with a low GOS, though not significantly. Conclusions: In addition to GCS, type of trauma, type of brain lesion and certain coagulation abnormalities are predictors of GOS.

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“…Repeated unsuccessful attempts to halt severe intracranial bleeding often becomes progressively more technically difficult, more desperate in character, and, in patients with extensive parenchymal injury from trauma, the severe coagulopathy often develops into disseminated intravascular coagulation [5,6,7,8,9,10]. This cascade increases the risk for additional parenchymal injury from traction, disruption of more blood vessels, and worsening hemorrhage with a likely outcome of either poor survival status or death from exsanguination.…”

Section: Discussionmentioning

confidence: 99%

Packing to Tamponade Severe Intracranial Hemorrhage in Pediatric Patients

Winston

Byers²,

Freeman³

et al. 2015

Pediatr Neurosurg

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The medical records of all children in whom packing was used to control severe intracranial hemorrhage were reviewed. Eight children, with ages ranging from newborn to 4 years, met the inclusion criteria and all survived. Five were victims of severe closed head trauma, 2 had received penetrating cranial injuries, and 1 developed severe bleeding while undergoing surgery for a malignant tumor in the posterior fossa. Blood loss at the time of removal of the packing was minimal in 7 patients and was surgically controllable in the other. Packing is a simple, efficient, and safe maneuver which can very often halt intracranial bleeding that is considered to be otherwise uncontrollable, and can thereby limit the consequences of prolonged or repeated periods of hypotension and possible exsanguination.

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Disseminated intravascular coagulation following cranial trauma

Cited by 47 publications

References 23 publications

Diffuse Intravascular Coagulation Associated with Brain Tumor Surgery in Children

Diffuse Intravascular Coagulation Associated with Brain Tumor Surgery in Children

The Influence of Hemocoagulative Disorders on the Outcome of Children with Head Injury

Packing to Tamponade Severe Intracranial Hemorrhage in Pediatric Patients

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