Disseminated Intravascular Coagulation as the Initial Presentation of Metastatic Prostate Adenocarcinoma

Greenberg, Daniel J.

doi:10.7759/cureus.14845

Cited by 2 publications

(4 citation statements)

References 9 publications

(10 reference statements)

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“…The incidence of DIC in patients with prostate cancer is estimated between 13% and 30% 2 . Although DIC is a coagulopathy that often complicates prostate cancer, it has been rarely reported as the initial presentation of prostate cancer 3–5 …”

Section: Introductionmentioning

confidence: 99%

“… 2 Although DIC is a coagulopathy that often complicates prostate cancer, it has been rarely reported as the initial presentation of prostate cancer. 3 , 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

“…2 Although DIC is a coagulopathy that often complicates prostate cancer, it has been rarely reported as the initial presentation of prostate cancer. [3][4][5] Herein, we reported a 68-year-old man who presented with a gradual deterioration of consciousness, dyspnea, and lower limb edema who later was discovered to have DIC and subdural…”

mentioning

confidence: 98%

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A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage

Shafie,

Shahmohamadi,

Hadizadeh

et al. 2023

Cancer Reports

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BackgroundDisseminated intravascular coagulation (DIC) has been reported in various solid malignancies and is a common coagulation‐related complication in prostate cancer. However, DIC has been rarely reported as the initial presentation of prostate cancer. Herein, we reported a patient referring with subdural hemorrhage (SDH) and DIC with an unexplained cause who was later diagnosed with prostate cancer.Case PresentationWe presented a 68‐year‐old man who was referred to the hospital with a gradual deterioration of consciousness, dyspnea, and edema in the genitalia and lower limbs. His primary laboratory tests showed elevated prothrombin time (PT) and partial thromboplastin time (PTT) and a decreased fibrinogen level of 47 mg/dL [200–400 mg/dL]. The DIC score was 7, which was suggestive of DIC. Moreover, cranial imaging showed SDH. Further work‐up revealed elevated prostate‐specific antigen and prostate enlargement with a mass effect on the bladder with a bone lesion, which was suggestive of metastatic prostate cancer.ConclusionThis report highlights DIC as a possible initial presentation of an underlying malignancy, as well as the importance of treatment of underlying disease in the management of DIC. A comprehensive and systematic work‐up is essential for early diagnosis in patients with DIC to avoid further complications and mortality.

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Section: Introductionmentioning

confidence: 99%

“… 2 Although DIC is a coagulopathy that often complicates prostate cancer, it has been rarely reported as the initial presentation of prostate cancer. 3 , 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

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A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage

Shafie,

Shahmohamadi,

Hadizadeh

et al. 2023

Cancer Reports

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“…The following are available online at : Supplementary Material S1: PRISMA 2020 Checklist [ 54 ]; Supplementary Material S2: List of Excluded Studies [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ].…”

mentioning

confidence: 99%

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Abufaraj,

Ramadan,

Alkhatib

2024

Current Oncology

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Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS. A total of 17 articles were included in the review. Among these, Cushing’s Syndrome (CS) due to ectopic Adrenocorticotropic hormone (ACTH) secretion was the most commonly reported PNS. Other PNS included syndrome of inappropriate Anti-Diuretic Hormone secretion (SIADH), Anti-Hu-mediated chronic intestinal pseudo-obstruction (CIPO), limbic encephalitis, Evans Syndrome, hypercalcemia, dermatomyositis, and polycythemia. Many patients had a history of prostate adenocarcinoma treated with androgen deprivation therapy (ADT) before neuroendocrine features developed. The mean age was 65.5 years, with a maximum survival of 9 months post-diagnosis. NEPC is becoming an increasingly more common subtype of PCa that can result in various PNS. This makes the diagnosis and treatment of NEPC challenging. Further research is crucial to understanding these syndromes and developing standardized, targeted treatments to improve patient survival.

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Disseminated Intravascular Coagulation as the Initial Presentation of Metastatic Prostate Adenocarcinoma

Cited by 2 publications

References 9 publications

A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage

A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

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