Disseminated Histoplasmosis with Oral Manifestation in an Immunocompetent Patient

Chatterjee, Debopriya; Chatterjee, Aishwarya; Agarwal, Manoj; Mathur, Meetu; Mallikarjun, ReddyN; Banerjee, Subrata

doi:10.1155/2017/1323514

Cited by 8 publications

(9 citation statements)

References 8 publications

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“…Areas such chicken coops, bird roosts, caves and building sites harbour high level of Histoplasma capsulatum . People with exposure to such areas along with immunosuppression are susceptible to Histoplasmosis [2,3]. Gupta et al analyzed 95 published studies with 204 cases from India.…”

Section: Discussionmentioning

confidence: 99%

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Disseminated Histoplasmosis presenting as oropharyngeal mass lesion

Choudhury¹,

Baruah²,

Shah³

et al. 2019

Medical Mycology Case Reports

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A 62 year old man from Silchar in North East India presented with complaints of painful swallowing, hoarseness, fever, anorexia and weight loss. Oropharyngeal examination revealed reddish ulcero-nodular lesion involving left tonsillar area and base of tongue which was clinically suspicious of malignancy. Radiological examination revealed involvement of bilateral adrenals by a mass. The biopsy of the oropharyngeal lesion showed many fungal spores morphologically favoring Histoplasmosis. Treatment with Amphotericin B followed by Itraconazole resulted recovery of lesions.

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Section: Discussionmentioning

confidence: 99%

“…Human and animal infections are caused by inhalation of fungus in dust [1]. In India, Histoplasmosis is endemic in West Bengal and Gangetic delta [2]. In humans Histoplasmosis may occur in three form: (i) Primary acute pulmonary form, (ii) chronic pulmonary and (iii) disseminated form.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Histoplasmosis presenting as oropharyngeal mass lesion

Choudhury¹,

Baruah²,

Shah³

et al. 2019

Medical Mycology Case Reports

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“…Infection is largely caused by inhalation of droppings from infected birds or bats. Histoplasma capsulatum mainly infects the lungs and passes asymptomatically to involve the skin and reticuloendothelial system [ 1 ]. In immunocompetent individuals without underlying structural lung disease, the infection is usually benign and asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…Histoplasmosis is extremely rare in presumed immunocompetent patients who do not reside in endemic areas [ 1 ]. This is a case of a young male who presented with right middle lobe pneumonia, later diagnosed with histoplasmosis and immunoglobulin (IgM) deficiency.…”

Section: Introductionmentioning

confidence: 99%

Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency

Preneta

Nada

Raja

et al. 2018

Case Reports in Infectious Diseases

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Chronic histoplasmosis is typically diagnosed in patients who are immunocompromised or severely debilitated and who either live in or who have travelled to endemic areas. We report the case of a young, otherwise immunocompetent male patient who presented to a New York hospital with lobar consolidation and was found to have chronic pulmonary histoplasmosis. He described no history of travel to an endemic area. Immunological workup later revealed selective immunoglobulin M (IgM) deficiency. The literature has suggested a link between IgM deficiency and fungal infections. Recent research has also proposed a link between autoimmunity and IgM deficiency. Our clinical vignette describes the case of a patient with selective IgM deficiency who was diagnosed with pulmonary histoplasmosis without any clinical evidence of autoimmune disease.

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“…To the best of our knowledge, the literature contains only 1 report of an immunocompetent patient presenting with laryngeal histoplasmosis 12 and only 4 cases of patients with an oral lesion. [13][14][15][16] Considering the rarity of histoplasmosis of the head and neck in immunocompetent patients, the paucity of reports, and the constellation of nonspecific symptoms, few clinicians possess the knowledge needed to make a proper diagnosis. In this article, we describe the cases of 2 immunocompetent patients who presented with a head and neck manifestation of histoplasmosis-one involving the oral cavity and the other the larynx.…”

Section: Introductionmentioning

confidence: 99%

Histoplasmosis of the Head and Neck in the Immunocompetent Patient: Report of 2 Cases

Ferster

Jaworek

2018

Ear Nose Throat J

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Histoplasmosis of the head and neck is rarely seen in immunocompetent patients. We report 2 new cases of histoplasmosis of the head and neck in immunocompetent patients, one an 80-year-old man and the other a 57-year-old man. The older man presented with oral cavity histoplasmosis; his symptoms included pain, dysphagia, and ulcerative lesions. The younger man had laryngeal histoplasmosis, which resulted in hoarseness and dyspnea. We discuss the methods of diagnosis and the classic findings in histoplasmosis, including the microscopic appearance of caseating granulomas, the results of periodic acid-Schiff staining and Gomori staining, and antibody detection of histoplasmosis. We also review the treatment options with antifungals, including amphotericin B and the oral conazole drugs. With an accurate diagnosis and proper treatment, both of our patients recovered well and their symptoms resolved. Because their symptoms overlapped with those of other, more common disease processes, an accurate diagnosis of these patients was essential to treating their infection.

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Disseminated Histoplasmosis with Oral Manifestation in an Immunocompetent Patient

Cited by 8 publications

References 8 publications

Disseminated Histoplasmosis presenting as oropharyngeal mass lesion

Disseminated Histoplasmosis presenting as oropharyngeal mass lesion

Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency

Histoplasmosis of the Head and Neck in the Immunocompetent Patient: Report of 2 Cases

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