Disseminated Histoplasmosis with Concurrent Hairy Cell Leukemia

Khan, Abdul Moiz; Shahzad, Sheikh Raza; Najjar, Saleh; Foulke, Llewellyn

doi:10.7759/cureus.6825

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2021

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“…Clinically, features of disseminated histoplasmosis and hairy cell leukemia often overlap. They both present with fevers, weight loss, night sweats, hepatosplenomegaly, pancytopenia and pulmonary infiltrate [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis

Fohle¹,

Seth²,

Matta³

2021

Cureus

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Histoplasmosis is usually self-limiting in healthy individuals but often fatal in immunocompromised patients. It can mimic primary lung malignancy and liver metastasis, causing a delay in appropriate therapy. We report a case of a 58-year-old male, with a 20 pack-year smoking habit, who presented with a three-week history of persistent fevers and productive cough with night sweats. Computed tomography (CT) scan of chest, abdomen and pelvis showed findings suggestive for primary lung malignancy associated with liver metastasis. Liver biopsy showed budding yeast. Bronchoalveolar lavage (BAL) fluid grew fungal organisms. Urine and serology were positive for histoplasmosis. Patient was pancytopenic, hence, we decided to evaluate further with a bone marrow biopsy which revealed underlying hairy cell leukemia. In the case of disseminated histoplasmosis, a high degree of suspicion towards any immunosuppressive condition should be entertained and any signs should be promptly investigated.

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Section: Discussionmentioning

confidence: 99%