Disseminated histoplamosis

Abstract

A case of disseminated histoplasmosis in a 45-year-old male patient with acquired immunodeficiency syndrome (AIDS) from Pune is reported. The patient presented with high-grade fever and pain in hypochondrium. Clinical signs were pallor and hepatosplenomegaly. Bone marrow and splenic aspirate revealed numerous intracellular oval shaped yeast forms. Histoplasma capsulatum was isolated from the bone marrow and splenic aspirate. H. capsulatum infection is an opportunistic infection usually reported from patient with AIDS in areas endemic for H. capsulatum. The present case highlights the fact that histoplasmosis could be an emerging opportunistic infection in India.

Cutaneous histoplasmosis in a HIV seronegative patient

“…[3] Three main clinical manifestations of histoplasmosis are pulmonary, progressive disseminated and chronic cavitory forms: all may be accompanied with skin lesions, or rarely, the disease manifests as PCH. [4] PCH in immunocompetent individuals itself is very rare, with hardly three case reports, and can present with nodules, ulcers and abscesses. [35]…”

A rare case of juvenile systemic lupus erythematosus with disseminated histoplasmosis

“…[9] Disseminated histoplasmosis is quite rare and is seen in only 10% of patients with histoplasmosis,[4] particularly seen in immunocompromised individuals like those receiving immunosuppressive drugs and corticosteroids after transplantation, or suffering from acquired immunodeficiency syndrome. [9]…”

“…Progressive disseminated histoplasmosis (PDH) which commonly affects immunocompromised patients represents a severe form of the disease. [345]…”

SkIndia Quiz 10 - Papulonodular lesions in a Human Immunodeficiency Virus-positive patient

“…[1] Histoplasmosis is found throughout the world, but is endemic in the central Eastern part of united states especially, Ohio and lower Mississippi river valleys. [2] Several cases have been reported from India,[345] although cultural confirmation has been obtained only in some. [2] Histoplasmosis may occur in three major clinical forms: Primary cutaneous, pulmonary, and progressive disseminated histoplasmosis.…”

“…[2] Several cases have been reported from India,[345] although cultural confirmation has been obtained only in some. [2] Histoplasmosis may occur in three major clinical forms: Primary cutaneous, pulmonary, and progressive disseminated histoplasmosis. [6] Since the onset of the acquired immunodeficiency syndrome pandemic, disseminated histoplasmosis has become a more common opportunistic fungal infection.…”