Disseminated extramedullary plasmacytomas

Burke, William A.; Merritt, Carolyn C.; Briggaman, Robert A.

doi:10.1016/s0190-9622(86)70038-8

Cited by 34 publications

(5 citation statements)

References 12 publications

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“…Extramedullary disease in MM is a recognised manifestation of MM characterised by involvement of different anatomical sites distant from the bone marrow including lymph nodes, skin, breast, liver, central nervous system [5][6][7][8][9][10][11][12][13]. Pericardial involvement is particularly rare with myelomatous pericardial effusions present in less than 1% of all cases of MM [3].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Tamponade as First Manifestation of Multiple Myeloma: a Case Report With Literature Review

LOUKHNATI

Khalil

LAHLIMI

et al. 2021

Preprint

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Background: Multiple myeloma is a hematologic malignancy characterized by clonal proliferation of plasma cells, mainly in bone marrow. Extramedullary disease is reported in many cases and may occur at diagnosis, at progression, or during relapse phase. Pericardial involvement is a rare condition that usually occurs with advanced-stage disease. We report a rare case of plasma cell-based pericardial effusion with cardiac tamponade as a form of presentation of multiple myeloma.Case presentation: A 76-year-old woman was admitted to the emergency department for worsening shortness of breath, on segmental examination, she had dyspnea, engorged jugulars, muffled heart sounds and lower limb edema. A Chest X-ray demonstrated cardiomegaly with a mild left pleural effusion, laboratory data showed immunoglobulin G lambda, diagnosis of plasma cell-based pericardial effusion was established by pericardial fluid cytology. The patient received systemic chemotherapy, according to Melphalan-Prednisone and thalidomid protocol. Conclusion: Multiple myeloma with cardiac effusion should be considered for differential diagnosis of patients with recurrent and unexplained pericardial effusions.

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Section: Discussionmentioning

confidence: 99%

Cardiac Tamponade as First Manifestation of Multiple Myeloma: a Case Report With Literature Review

LOUKHNATI

Khalil

LAHLIMI

et al. 2021

Preprint

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“…In our case, two skin‐colored subcutaneous nodules on the forehead and left side of the chest were presented. There are two categories of cutaneous plasmacytoma: primary cutaneous plasmacytoma develops without evidence of myeloma and has been associated with paraproteinemia 9–11 . It has been reported to progress to multiple myeloma in approximately 20% of cases, despite a negative evaluation at presentation 11–13 .…”

Section: Discussionmentioning

confidence: 99%

“…There are two categories of cutaneous plasmacytoma: primary cutaneous plasmacytoma develops without evidence of myeloma and has been associated with paraproteinemia. [9][10][11] It has been reported to progress to multiple myeloma in approximately 20% of cases, despite a negative evaluation at presentation. [11][12][13] Secondary cutaneous plasmacytoma develops in association with multiple myeloma (called "metastatic plasmacytoma"), or as a direct extension of an underlying bone lesion.…”

Section: Discussionmentioning

confidence: 99%

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

2004

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A variety of cutaneous manifestations has been described in multiple myeloma including extramedullary cutaneous plasmacytomas, cutaneous amyloidosis, pyoderma gangrenosum, leukocytoclastic vasculitis, necrobiotic xanthogranuloma, scleromyxedema, Sweet's syndrome, subcorneal pustular dermatosis, scleredema, and plane xanthomas etc. An 89-year-old Korean man, who had been suffering from multiple myeloma 1 year previous, presented for evaluation of two nodules on the right side of the forehead, left side of the chest (7th rib area), and multiple ulcers with papulopustules on both the thigh and the left side of the chest (2nd rib area) during 15 days, which developed at the same time. A biopsy of a lesion which manifested as a cutaneous nodule on the right side of the forehead revealed dermal infiltration by well-differentiated plasma cells, similar to those found on a bone marrow biopsy, and a biopsy of the lesion manifested as a painful ulceration on the right thigh area showing dermal neutrophilic infiltration. Histologic findings were consistent with plasmacytoma and pyoderma gangrenosum, respectively. We present a case of multiple myeloma which developed extramedullary cutaneous plasmacytoma and pyoderma gangrenosum simultaneously, which is very rare. The patient was treated with a systemic steroid and conservative therapy.

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“…Plasma cell cheilitis usually occurs as a single lesion, although multiple lesions occasionally develop in anatomically neighboring sites. Simultaneous development of multiple lesions on the lips and distant sites was anecdotally reported . Plasma cell cheilitis is considered to be a relatively stable disease and its progression to malignancy has not been reported…”

Section: Introductionmentioning

confidence: 99%

“…Simultaneous development of multiple lesions on the lips and distant sites was anecdotally reported. 3 Plasma cell cheilitis is considered to be a relatively stable disease and its progression to malignancy has not been reported. 4 Although pathogenesis of plasma cell cheilitis is unknown, it has been proposed that peripheral circulatory failure may cause local abnormal protein metabolism and stimulation of plasma cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Successful treatment with 308‐nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis

Yoshimura

Nakano²,

Tsuruta

et al. 2013

The Journal of Dermatology

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Plasma cell cheilitis is a chronic inflammatory disease that presents with erythema, erosions, ulcers and occasional nodules within the mucosa, including the lips. It is histopathologically characterized by dense plasma cell infiltration in the lamina propria of the mucous membranes. Several treatments for plasma cell cheilitis have been reported, including topical steroids, topical antibiotics or topical tacrolimus. However, 308-nm monochromatic excimer light (MEL) has never been reported as a treatment option, while it was reported to be very effective in treating erosive oral lichen planus. We report a 62-year-old man who had chronic plasma cell cheilitis on the lower lip, which was refractory to topical and systemic corticosteroid. The lesion and severe pain were significantly improved by the treatment with nine sessions of 308-nm MEL twice per week with a total dose of 1120 mJ/cm(2). However, the lesion gradually worsened after treatment frequency was reduced to once per month. Subsequent tacrolimus 0.03% ointment cleared the lesion completely in a month and no recurrence was observed a year later. Refractory plasma cell cheilitis and concomitant severe pain quickly responded to 308-nm MEL when administrated twice per week. Because the long interval between each MEL treatment seemed ineffective to improve the lesion, appropriate frequency and adequate total dose of MEL treatment may be necessary for a successful treatment.

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Disseminated extramedullary plasmacytomas

Cited by 34 publications

References 12 publications

Cardiac Tamponade as First Manifestation of Multiple Myeloma: a Case Report With Literature Review

Cardiac Tamponade as First Manifestation of Multiple Myeloma: a Case Report With Literature Review

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

Successful treatment with 308‐nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis

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