Disseminated cutaneous with nasopharyngeal rhinosporidiosis: Light microscopy changes following dapsone therapy

Madke, Bhushan; Mahajan, Sunanda; Kharkar, Vidya; Chikhalkar, Siddhi; Khopkar, Uday

doi:10.1111/j.1440-0960.2010.00633.x

Cited by 18 publications

(14 citation statements)

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“…A case of disseminated rhinosporidiosis with cutaneous, laryngeal and nasopharyngeal involvement has also been reported from India [15]. Another disseminated case of nasopharyngeal rhinosporidiosis in a 48-yearold man with a six-month history of six subcutaneous swellings on the body, and a five-year history of a pea- sized swelling on the inner aspect of the lower eyelid, a rarely known clinical presentation of the disease, has also been reported from Mumbai in Western India [16]. There are several reports of cases of ocular rhinosporidioisis form many parts of India [4,12,[17][18][19][20], some of them dealing with large series of cases [17][18][19].…”

Section: Discussionmentioning

confidence: 91%

Ocular rhinosporidiosis: a case report from Delhi

Sood

Agarwal

Gugnani³

2012

J Infect Dev Ctries

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Rhinosporidiosis caused by Rhinosporidium seeberii, a protistal microorganism, is endemic in several parts of India. Infection involves mucous membranes of the nose and paranasal sinuses and usually manifests as vascular friable polyps. A few cases of rhinosporidoisis have been reported from Delhi, in patients who were migrants from other states. The present case constitutes the first report of rhinosporidiosis in a Delhi resident; the lesion occurred as polypoidal mass of the palpebral conjunctiva.

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Section: Discussionmentioning

confidence: 91%

Ocular rhinosporidiosis: a case report from Delhi

Sood

Agarwal

Gugnani³

2012

J Infect Dev Ctries

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“…Dapsone (diaminodiphenylsulfone) is a relatively safe drug to use, and no major side effects were noticed in this trial (Nair, 1979). In one study, dosage of 100 mg/day of dapsone for several months is recommended in human patient to prevent the recurrence of disease after surgical removal ( Job et al, 1993;Crosara et al, 2009;Madke et al, 2011). Immunological response is not of much value.…”

Section: Treatmentmentioning

confidence: 84%

Rhinosporidiosis: A Riddled Disease of Man and Animals

Tiwari¹

2015

Adv. Anim. Vet. Sci.

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| Rhinosporidiosis is a non-contagious, sporadic, chronic granulomatous infection of man and large domestic animals, characterised by the production of large polyps with high recurrence rate. Polyps occur mainly in nasal, ocular regions; cutaneous and disseminated forms are relatively rare. Spread of these organisms to other areas in an affected person may involve blood, lymph or auto infection. Rhinosporidiosis has been reported form more than 70 countries and mainly the reports are concentrated from Sri Lanka and Southern India. Surgical removal of the polyp will be the cure and in some cases dapsone has given some cure. From the day of inception of this disease there had been a controversy for causative agent of this condition among eukaryotic protozoan parasite or algae or fungi or prokaryotic blue green algae which finally confirmed as a fungi Rhinosporidium seeberi. Recent works by various researchers shows that R. seeberi belong to the class Mesomycetozoea. Other mystery remains in its habitat and its inability to be cultured on laboratory media. Similarly, laboratory animal infection does not yield classical form of disease as it does in human and large animals. The pathogen is so mysterious that the mechanism behind evasion of immune mechanism is also not clear. Still various aspects of disease such as mode of transmission, mechanism of infection, biology of rhinosporidiosis, immunological response and laboratory culture techniques are unresolved mysteries due to paucity of documented data which demands more exploration. This review illustrates main features of rhinosporidiosis and systematic approaches for the diagnosis and treatment of this controversial pathogen.

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“…Most cases of nasal tuberculosis are unilateral and lesions can be proliferative, infiltrative or ulcerative or round in shape filled with spores which may be seen bursting through its chitin walls (11). Rhinoscleroma is another differential diagnosis with demonstration of characteristic Mikulicz cells in its histology (12).…”

Section: Discussionmentioning

confidence: 99%