Disseminated cutaneous sporotrichosis in patient with alcoholism

Benvegnú, Ana Maria; Stramari, Juliana Mazzoleni; Dallazem, Lia Natália Diehl; Chemello, Raíssa Massaia Londero; Beber, André Avelino Costa

doi:10.1590/0037-8682-0281-2017

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…The man had no medical condition, only alcoholism for more than three decades, therefore, based on the data, it was diagnosed sporotrichosis of the skin disseminated non-systemic, in an ethylist man who during his anamnesis reported to reside in an endemic site of the disease. 14 The hypothesis of susceptibility to fungal infection was alcoholic dependence, which corroborates with the case described by Barros and collaborators (2020), however, distinguishing in the diagnosis, such cases were compared to emphasize that even having the extrinsic factor, alcoholic dependence, they had singular diseases. 11 The literature emphasize that the immunological response to the fungal infection by the genus Sporothrix is based on in vitro studies and experimental specimen of rodents, being the data from humans still scarce.…”

Section: Discussionsupporting

confidence: 76%

Signs of Sucettability Associated With Extrinsic Factors to Fungal Infection by the Genus Sporothrix Spp.

Rezende¹,

Teodoro²

2021

IJBM

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Objective: To evaluate the susceptibility to infection by the genus sporothrix spp.; targeting patients with immunosuppression due to the use of inadequate medication, seropositive patients (carriers of Human Immunodeficiency Syndrome – HIV) and alcoholics dependents. Method: This is an integrative review of the literature available in the PUBMED database, using the descriptors: “Sporotrichosis”, “Fungi” and “Sporothrix”, duly registered in MeSH, using the boolean operator AND. A total of 128 articles were found and evaluated and, at the end, 15 were selected to compose this review. The inclusion criteria were: full articles, available free of charge, published in English between 2010 and 2020. Results: Sporotrichosis is clinically characterized in fixed cutaneous, lymphocutaneous, disseminated cutaneous and extracutaneous. Frequently the appearance of disseminated cutaneous sporotrichosis occurs especially in immunosuppressed individuals. The four cases evaluated have as etiological agent in common, the genus Sporothrix spp., distinguishing the species, the contagion, clinical aspects and their susceptibility factors. Conclusion: However, most cases of sporotrichosis are related to a dysfunction of the immune system. As well, the unusual cases characterize a challenge to reliable diagnosis and can often lead to a wrong pharmacological therapy.

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Section: Discussionsupporting

confidence: 76%

Signs of Sucettability Associated With Extrinsic Factors to Fungal Infection by the Genus Sporothrix Spp.

Rezende¹,

Teodoro²

2021

IJBM

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“…The most emblematic case of disseminated disease occurred in a diabetic and alcoholic patient who developed a fatal fungemia after 17 days of hospitalization [110]. The other cases corresponded to isolated monoarthritis, endophthalmitis and cutaneous disseminated sporotrichosis [111,112,113].…”

Section: Comorbidities As Risk Factors For Sporotrichosismentioning

confidence: 99%

Sporotrichosis In Immunocompromised Hosts

Queiroz‐Telles

Buccheri

Benard

2019

JoF

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Sporotrichosis is a global implantation or subcutaneous mycosis caused by several members of the genus Sporothrix, a thermo-dimorphic fungus. This disease may also depict an endemic profile, especially in tropical to subtropical zones around the world. Interestingly, sporotrichosis is an anthropozoonotic disease that may be transmitted to humans by plants or by animals, especially cats. It may be associated with rather isolated or clustered cases but also with outbreaks in different periods and geographic regions. Usually, sporotrichosis affects immunocompetent hosts, presenting a chronic to subacute evolution course. Less frequently, sporotrichosis may be acquired by inhalation, leading to disseminated clinical forms. Both modes of infection may occur in immunocompromised patients, especially associated with human immunodeficiency virus (HIV) infection, but also diabetes mellitus, chronic alcoholism, steroids, anti-TNF treatment, hematologic cancer and transplanted patients. Similar to other endemic mycoses caused by dimorphic fungi, sporotrichosis in immunocompromised hosts may be associated with rather more severe clinical courses, larger fungal burden and longer periods of systemic antifungal therapy. A prolonged outbreak of cat-transmitted sporotrichosis is in progress in Brazil and potentially crossing the border to neighboring countries. This huge outbreak involves thousands of human and cats, including immunocompromised subjects affected by HIV and FIV (feline immunodeficiency virus), respectively. We reviewed the main epidemiologic, clinical, diagnostic and therapeutic aspects of sporotrichosis in immunocompromised hosts.

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“…[6][7][8] The latter is rare and usually related with immunosuppression. 9,10 Sporotrichosis is considered the main subcutaneous mycosis in Latin America. It is endemic to Mexico, Guatemala, Costa Rica, Panama, Colombia, Venezuela, Brazil, Peru, Bolivia, Argentina, and Uruguay.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Caus

Zanotti

Faccini-Martínez

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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This study discusses a historical patient series and is designed to describe clinical and epidemiological characteristics of human sporotrichosis in the state of Espírito Santo, Brazil. Data were derived from patients treated at the Infectious Diseases service of Cassiano Antônio Moraes University Hospital in Vitória, the state capital, from July 1982 to June 2012. A total of 171 patients were diagnosed with sporotrichosis, mostly men (80.7%) with a median age of 33 years and 5 months. We can presume an approximate average incidence rate of 4.9 cases per 100,000 inhabitants during the studied period. All the patients were involved in occupational or leisure activities with direct contact with soil or plants. Most cases were recorded in the mountainous region of the state during the hot and rainy periods. The average time elapsed from lesion progression to diagnosis was 3 months, with the lymphocutaneous form being the most common (70.2%), followed by the fixed cutaneous form (28.6%). Diagnosis was confirmed in 93.6% of the cases by culturing Sporothrix spp. in Sabouraud dextrose agar, and from the clinical features in the remaining cases. Aspiration of cutaneous nodule secretions was the best method for the collection of clinical specimens for disease diagnosis. A 25% saturated solution of potassium iodide (SSKI) was provided to almost all patients (98.8%), with therapeutic success. In conclusion, in this retrospective study in the state of Espírito Santo, we found that sporotrichosis affects primarily the ³ 10-year-old population, and the most common presentation is the lymphocutaneous form affecting the lower and upper limbs, and the infection appeared to be acquired predominantly through occupational activities. Treatment with SSKI was safe and effective.

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Disseminated cutaneous sporotrichosis in patient with alcoholism

Cited by 8 publications

References 10 publications

Signs of Sucettability Associated With Extrinsic Factors to Fungal Infection by the Genus Sporothrix Spp.

Signs of Sucettability Associated With Extrinsic Factors to Fungal Infection by the Genus Sporothrix Spp.

Sporotrichosis In Immunocompromised Hosts

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

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