Disseminated cutaneous herpes zoster complicated by acyclovir nephrotoxicity and successfully treated with brivudin

Aksoy, Berna; Altaykan-Hapa, Aslı; Cengiz, A. Tevfik; Aksoy, Hasan Mete; Atakan, Nilgün

doi:10.1684/ejd.2010.0894

Cited by 6 publications

(1 citation statement)

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“…1). It is a highly potent inhibitor of Herpes simplex virus type1 [1] and Varicella zoster virus [2][3][4]. It is also used in anticancer therapy [5].…”

Section: Introductionmentioning

confidence: 99%

LC–MS–MS Quantitative Determination of Brivudine in Human Plasma and Its Application to Pharmacokinetic Studies

PeiShan¹,

Chen²,

FanWei³

2011

Chromatographia

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A sensitive and specific liquid chromatography-electrospray ionization-tandem mass spectrometry method has been developed and validated for the identification and quantification of brivudine in human plasma using diclofenac as an internal standard. The method involves extraction with ethyl acetate. The analyte was separated on a C 18 column and analyzed in multiple reaction monitoring mode with a negative electrospray ionization interface using the [M-H] -ions, m/z 332.8? m/z 80.9 for brivudine, m/z 293.6?m/z 249.5 for diclofenac. The method was validated over the concentration range of 5.54-2,836 lg L -1 for brivudine. The intra-and inter-day precisions were less than 8.91% in terms of relative standard deviation (RSD), and the accuracy was within -4.22% in terms of relative error (RE). The lower limit of quantification (LLOQ) was 5.54 lg L -1 with acceptable precision and accuracy. There were almost no matrix effects. Recovery of brivudine spiked in drug-free plasma was higher than 77.17%. The method was used to study the pharmacokinetic profile of brivudine in human plasma after oral administration of brivudine tablets.

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“…1). It is a highly potent inhibitor of Herpes simplex virus type1 [1] and Varicella zoster virus [2][3][4]. It is also used in anticancer therapy [5].…”

Section: Introductionmentioning

confidence: 99%

LC–MS–MS Quantitative Determination of Brivudine in Human Plasma and Its Application to Pharmacokinetic Studies

PeiShan¹,

Chen²,

FanWei³

2011

Chromatographia

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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