Disseminated cutaneous granulomatous eruptions associated with myelodysplastic syndrome and acute myeloid leukaemia

Vestey, J.P.; Turner, M.; Biddlestone, L.; McLaren, K M; Goulden, Nicholas; Hunter, John

doi:10.1111/j.1365-2230.1993.tb01031.x

Cited by 37 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GA-associated malignancies have been reported in Hodgkin’s disease [1, 7], non-Hodgkin’s lymphoma [1], chronic lymphocytic lymphoma [1], seminoma [8], myelodysplastic syndrome [9], acute myeloid leukemia [9]and metastatic adenocarcinoma [10]. However, to the best of our knowledge, generalized GA associated with GrMF has not been previously reported.…”

Section: Discussionmentioning

confidence: 78%

Generalized Granuloma annulare Associated with Granulomatous Mycosis fungoides

Wong

Yang²,

Kuo³

et al. 2000

Dermatology

View full text Add to dashboard Cite

We describe a 68-year-old man with plaque stage mycosis fungoides (MF) for 8 years. He developed tumorous lesions of granulomatous MF (GrMF) and generalized granuloma annulare (GA) after a previously indolent clinical course. Since then, the clinical course was aggressive with involvement of the bone marrow and lymph nodes, and leukemic change occurred. Systemic chemotherapy was given, but the patient died 9 months later due to neutropenic fever and septic shock. GA in malignant lymphoma has been reported most frequently in association with Hodgkin’s disease. To the best of our knowledge, GA associated with GrMF has never been reported in the English language literature. The prognostic significance of the association of granulomatous inflammation and malignancy is reviewed.

show abstract

Section: Discussionmentioning

confidence: 78%

Generalized Granuloma annulare Associated with Granulomatous Mycosis fungoides

Wong

Yang²,

Kuo³

et al. 2000

Dermatology

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4] In addition, disseminated cutaneous granulomatous eruptions have been described in patients with MDS. [38][39][40] Vestey et al 39 described 2 cases of widespread papular granulomatous eruptions containing epithelioid granulomata with variable numbers of giant cells. The first case resembled granuloma annulare with transformation to acute myeloblastic leukemia and the second case of cutaneous sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

Cornejo

Lum²,

Izumi³

2013

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Cutaneous manifestations associated with myelodysplastic syndromes (MDS) are uncommon and can occur as specific or nonspecific lesions. Recognizing these cutaneous manifestations is important as they can precede blood or bone marrow transformation to leukemia. Granulomatous reactions have rarely been described as nonspecific lesions of MDS. These rare cases histologically resembled granuloma annulare, sarcoid, and a generalized dermal interstitial granulomatous dermatitis (IGD) which were not associated with leukemic infiltration. The authors report an interesting case of an IGD-like eruption evolving over the course of MDS with eventual progression to systemic leukemia. IGD is an inflammatory reaction that refers to a varied spectrum of histologic patterns and is associated with a variety of systemic illnesses and hypersensitivity reactions, including lymphoma and leukemia. In patients with MDS, surveillance for leukemia is a critical component of their follow-up care. Normally, this surveillance occurs through serial peripheral blood smears and bone marrow studies. IGD-like eruptions are a cutaneous reaction pattern that may serve as an additional clinical indicator of leukemic progression in patients with MDS. Although primarily a reactive pattern, this entity can rarely harbor leukemic blasts.

show abstract

“…The skin lesions subsided after his AML was controlled by chemotherapy. 5 Our patient had similar clinical manifestations, with eruptive GA appearing just weeks before AML transformation. However, more observations are needed to clarify the pathogenesis of this phenomenon and to determine whether GA and AML are simply coincidental events or whether the acute onset of generalized eruptive GA can be regarded as a paraneoplastic phenomenon.…”

mentioning

confidence: 52%