Disseminated cryptococcal infection in a patient with a remote renal transplant

Li, Kelli; Khan, Abid Ali; Mishra, Sharmistha; Zhabokritsky, Alice

doi:10.1503/cmaj.200825

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lungs and central nervous system (CNS) are the organs frequently affected by disseminated cryptococcosis. Involvements of other organs, including thyroid, liver, kidneys, pancreas, lymph nodes, spleen, intestine, and ovaries by Cryptococcus are also sporadically reported [ 3 ]. To the best of our knowledge, co-involvement of prostate and adrenal glands in cryptococcosis caused by C neoformans sensu stricto has been scarcely mentioned in human.…”

Section: Introductionmentioning

confidence: 99%

Disseminated cryptococcosis in a patient with idiopathic CD4 + T lymphocytopenia presenting as prostate and adrenal nodules: diagnosis from pathology and mNGS, a case report

Baomo,

Guofen,

Jie

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

Disseminated Cryptococcosis infection typically occurs in immunocompromised patients, often manifested as pneumonia or meningoencephalitis. Cases with involvement of either prostate or adrenal glands are less frequent. We describe a case of an immunocompromised 62-year-old man with new-found Idiopathic CD4 + T lymphocytopenia who presented with urinary irritation symptoms followed by headache. The patient was finally diagnosed as disseminated cryptococcosis of prostate, adrenal gland involvement with the help of combining histopathology of formalin-fixed, paraffin-embedded tissue with metagenomic next-generation sequencing technique to identify C neoformans sensu stricto in prostate, adrenal gland tissues. Clinicians should be aware of atypical presentations of cryptococcal disease. In this case of cryptococcosis in immunocompromised patients, we find that cryptococcosis can affect varied organs simultaneously and should be considered in the differential of infectious diseases. And mNGS technology helps to confirm the diagnosis.

show abstract

Section: Introductionmentioning

confidence: 99%