Disseminated candidiasis. Newer approaches to early recognition and treatment

Abstract

The clinical triad of fever, erythematous papular rash, and diffuse muscle tenderness has recently been reported to be presumptive evidence for disseminated candidiasis in the immunocompromised host who is receiving broad-spectrum antibiotics. This case report further explores this clinical association and demonstrates that the immediate institution of antifungal therapy before laboratory test results are known may favorably alter the outcome of this frequently fatal condition. In view of the low positive yield of blood cultures, skin biopsy may represent an effective method for achieving rapid laboratory confirmation of the diagnosis.

Acute disseminated candidiasis with skin lesions: a systematic review

“…The association between C. krusei fungemia and skin lesions was first reported in 1980 [13]. The first case series was published in 1992, with the description of seven patients with acute myeloid leukaemia who presented with embolic skin lesions in the setting of candidaemia due to C. krusei [14].…”