Disseminated aspergillosis in a dog: an immunohistochemical study

Pérez, J.; Mozos, E.; Lara, F. Chacón-M. de; Paniagua, Jorge; Day, Michael

doi:10.1016/s0021-9975(96)80041-7

Cited by 24 publications

(20 citation statements)

References 16 publications

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“…In the present study, canine periodontal T-lymphocytes were specifically immunolabeled with a polyclonal antibody raised against a highly conserved intracellular peptide sequence of the human CD3 antigen (Mason et al 1989;Jones et al 1993). These results are consistent with previous findings (Ferrer et al 1992(Ferrer et al ,1993Day 1996Day , 1997Pérez et al 1996Pérez et al ,1997 in which the use of this antibody was documented for the successful detection of canine T-lymphocytes in different inflamed extraoral soft tissue specimens. In our study, CD3 ϩ staining was mainly found in the connective tissue subjacent to the sulcus epithelium of the inflamed beagle periodontium.…”

Section: Discussionsupporting

confidence: 93%

Characterization of Immunocompetent Cells in the Diseased Canine Periodontium

Christgau

Caffesse

Newland

et al. 1998

J Histochem Cytochem.

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Section: Discussionsupporting

confidence: 93%

Characterization of Immunocompetent Cells in the Diseased Canine Periodontium

Christgau

Caffesse

Newland

et al. 1998

J Histochem Cytochem.

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“…A. fumigatus and A. flavus usually cause localized disease in the nasal cavity. A. terreus is most frequently associated with systemic aspergillosis in dogs, but A. deflectus and A. niger cause disease in some dogs 1–19 …”

mentioning

confidence: 99%

Clinicopathologic and Diagnostic Imaging Characteristics of Systemic Aspergillosis in 30 Dogs

Schultz

Johnson

Wisner

et al. 2008

Veterinary Internal Medicne

117

156

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Background: Systemic aspergillosis is a serious disease of dogs for which the clinical characteristics are poorly described. Objective: To describe the clinical and diagnostic imaging characteristics of dogs with systemic aspergillosis. Animals: Thirty dogs with systemic aspergillosis. Methods: Retrospective case review. Medical records were reviewed for signalment, clinical features, and results of clinicopathologic testing and diagnostic imaging. Diagnosis was confirmed by culture of Aspergillus terreus (n 5 13), Aspergillus deflectus (n 5 11), or other Aspergillus spp. (n 5 6).Results: Compared with the background hospital population, German Shepherd dogs and female dogs were overrepresented (odds ratio [OR] 43, 95% confidence interval [CI] 20-91, P o .0001, and OR 2.9, 95% CI 1.2-6.7, P 5 .02), respectively, with 20 of the 30 dogs being German Shepherd dogs and 77% (23 of 30) of the dogs being female. The median age was 4.5 years (range 2-8 years). Anemia, leukocytosis, hyperglobulinemia, azotemia, hypercalcemia, and hypoalbuminemia were present in 8, 21, 12, 9, 8, and 6 dogs, respectively. Diskospondylitis, osteomyelitis and thoracic lymphadenomegaly were present in 16, 10, and 5 dogs, respectively. Sonographic findings were enlarged hypoechoic lymph nodes (n 5 12), mottled and irregular kidneys with or without masses (n 5 12), pyelectasia, and an aggregate of echogenic material in the renal pelvis (n 5 9). Thirteen dogs were treated with antifungal drugs, with survival times ranging from 0 to 25 months after diagnosis.Conclusions and Clinical Importance: Systemic aspergillosis typically involves young to middle-age female German Shepherd dogs, and there are characteristic abdominal ultrasound findings with the disease process. Infection with A. deflectus was as common as A. terreus, and in rare cases, long-term survival was associated with antifungal therapy.

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“…German shepherd dogs make up a substantial number of the cases of canine paecilomycosis reported (Watt and others , Foley and others ) and are predisposed to fungal infections (Day and Penhale , Benitah ). The exact mechanism of their susceptibility to fungal infections is unclear; however, defects in mucosal immunity through IgA dysregulation (Day and Penhale ) and depressed local cellular responses (Pérez and others ) are possible. As a result of this susceptibility, recurrent and sequential fungal infections are reported in German shepherd dogs (Krockenberger and others ).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of bilateral paecilomyces pyelonephritis in a German shepherd dog

Tappin

Ferrandis

Jakovljevic

et al. 2012

J of Small Animal Practice

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A six-year-old female entire German shepherd dog was investigated for polyuria, polydipsia and lethargy. Investigations revealed a mild azotaemia and abdominal ultrasound revealed marked bilateral dilation of the renal pelves with echogenic material and proximal left hydroureter. Urine cytological examination and aspirates from the right renal pelvis revealed mats of fungal hyphae consistent with fungal bezoar formation. Fungal cultures revealed a profuse growth of Paecilomyces variotii. Initial treatment with oral itraconazole was unsuccessful, leading to bilateral nephrotomies to remove the fungal material. Postoperatively the Paecilomyces infection persisted despite continued itraconazole therapy. Treatment was commenced with amphotericin B, leading to resolution of the dog's clinical signs. To the authors' knowledge this is the first report of canine Paecilomyces pyelonephritis, without disseminated systemic disease, which documents its successful treatment.

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Disseminated aspergillosis in a dog: an immunohistochemical study

Cited by 24 publications

References 16 publications

Characterization of Immunocompetent Cells in the Diseased Canine Periodontium

Characterization of Immunocompetent Cells in the Diseased Canine Periodontium

Clinicopathologic and Diagnostic Imaging Characteristics of Systemic Aspergillosis in 30 Dogs

Successful treatment of bilateral paecilomyces pyelonephritis in a German shepherd dog

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