Disseminated Aspergillosis and Bleeding Colonic Ulcers in Renal Transplant Patient

Kinder, R. B.; Jourdan, Martin

doi:10.1177/014107688507800414

Cited by 13 publications

(9 citation statements)

References 4 publications

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“…From the lungs, Aspergillus spp. may disseminate to almost any organ, including the brain, liver, spleen, kidneys, heart, pericardium, blood vessels, thyroid, gastrointestinal tract, bones, and joints (125,189,316,342,349,470,655). Clinical manifestations of central nervous system aspergillosis include alteration of mental status, diffuse central nervous system depression, seizures, evolving cerebrovascular accidents, and headache (713,754).…”

Section: Mycelial Fungi (Excluding Zygomycetes)mentioning

confidence: 99%

Infections in solid-organ transplant recipients

1997

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Solid-organ transplantation is a therapeutic option for many human diseases. Infections are a major complication of solid-organ transplantation. All candidates should undergo a thorough infectious-disease screening prior to transplantation. There are three time frames, influenced by surgical factors, the level of immunosuppression, and environmental exposures, during which infections of specific types most frequently occur posttransplantation. Most infections during the first month are related to surgical complications. Opportunistic infections typically occur from the second to the sixth month. During the late posttransplant period (beyond 6 months), transplantation recipients suffer from the same infections seen in the general community. Opportunistic bacterial infections seen in transplant recipients include those caused by Legionella spp., Nocardia spp., Salmonella spp., and Listeria monocytogenes. Cytomegalovirus is the most common cause of viral infections. Herpes simplex virus, varicella-zoster virus, Epstein-Barr virus and others are also significant pathogens. Fungal infections, caused by both yeasts and mycelial fungi, are associated with the highest mortality rates. Mycobacterial, pneumocystis, and parasitic diseases may also occur.

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Section: Mycelial Fungi (Excluding Zygomycetes)mentioning

confidence: 99%

Infections in solid-organ transplant recipients

1997

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“…At present, histoplasmosis, 20 , 21 candidiasis, 13 and zygomycosis 22 – 25 have already been reviewed. In cases of other fungal infections, including cryptococcosis, 26 – 35 penicilliosis, 36 – 38 aspergillosis, 9 , 39 – 44 and paracoccidioidomycosis, 45 – 50 the author summarized case reports, as shown in Tables 1 – 4 . Only one case report was published for each of pneumocystosis 51 and scedosporiosis.…”

Section: Methodsmentioning

confidence: 99%

“…Colonic cryptococcosis and zygomycosis often occur in immunocompromised hosts, occurring in 77% 26 – 35 and 67% 22 of infections respectively, while colonic candidiasis, 13 penicilliosis, 36 – 38 and aspergillosis 9 , 39 – 44 exclusively occur in immunocompromised hosts. Risk factors for these infections are malignancy, taking immunosuppressive agents, chemotherapy, neutropenia, AIDS, renal failure, splenectomy, Job’s syndrome, cirrhosis, malnutrition, and diabetes mellitus; however, most colonic penicilliosis patients usually have AIDS.…”

Section: Risk Factorsmentioning

confidence: 99%

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Fungal infection of the colon

Praneenararat¹

2014

CEG

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Fungi are pathogens that commonly infect immunocompromised patients and can affect any organs of the body, including the colon. However, the literature provides limited details on colonic infections caused by fungi. This article is an intensive review of information available on the fungi that can cause colon infections. It uses a comparative style so that its conclusions may be accessible for clinical application.

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“…Although the portal of entry is usually pulmonary, there are rare reports of IA involving the gastrointestinal tract (3–7). However, the majority of these patients had coexistent lung lesions or disseminated aspergillosis.…”

mentioning

confidence: 99%

Invasive aspergillosis localised to the colon presenting as toxic megacolon

Mohite¹,

Kell²,

Haj³

et al. 2006

European J of Haematology

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Primary gut involvement by Aspergillus is an exceedingly rare and often a fatal complication of intensive chemotherapy in patients with acute leukaemia. We report a 46-yr-old patient with granulocytic sarcoma of the testis. He received acute myeloid leukaemia type treatment with ADE chemotherapy (Cytosine Arabinoside, Daunorubicin and Etoposide). While neutropenic he presented with pyrexia, abdominal pain and massive abdominal distention. He was treated with intravenous antibiotics and antifungals according to our usual institutional protocol without any response. He was found to have toxic megacolon on plain X-ray and subsequently underwent total colectomy and ileostomy. The colon histology showed Aspergillus fungal hyphae infiltrating the bowel wall. There was no any evidence of pulmonary, hepatic, splenic or renal lesions on the computerised tomography scan. Following colectomy, he was treated with 2 wk of antifungal treatment. He recovered well and was discharged home. The increased awareness, high degree of clinical suspicion of unusual presentation and early surgical intervention with aggressive antifungal treatment, has a key role in the management of these rare and often fatal cases.

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Disseminated Aspergillosis and Bleeding Colonic Ulcers in Renal Transplant Patient

Cited by 13 publications

References 4 publications

Infections in solid-organ transplant recipients

Infections in solid-organ transplant recipients

Fungal infection of the colon

Invasive aspergillosis localised to the colon presenting as toxic megacolon

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