Dissection of the Anti-Inflammatory Effect of the Core and C-Terminal (KPV) α-Melanocyte-Stimulating Hormone Peptides

Abstract

In this study, we analyzed the anti-inflammatory effects of ␣-melanocyte stimulating hormone (MSH) [11][12][13]

Mapping of a Novel Susceptibility Locus Suggests a Role for MC3R and CTSZ in Human Tuberculosis

“…MC1R was originally believed to be the key family member playing a role in inflammatory responses, mediating the proinflammatory effects of g-MSH in monocytes. However, recent work from Getting and colleagues suggests a more important role for MC3R (37). Getting and coworkers (38,39) have used a murine model of gouty inflammation to show that inhibition of MC3R reduces the response of peritoneal monocytes to an injection of urate crystals and, more recently, that it reduces the inflammatory reaction in a model of gouty arthritis (40).…”

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

“…Furthermore, ␣-MSH (11-13) reduced NF-B translocation to the nucleus much as the full-length ␣-MSH Barcellini et al, 2000;Mandrika et al, 2001). However, several observations indicate that this molecule does not compete with ␣-MSH for receptors expressed by the B16 mouse melanoma cells (Lyson et al, 1994) and does not recognize any of the known melanocortin receptors Mandrika et al, 2001;Getting et al, 2003b;Muceniece et al, 2003). Therefore, the cell receptor for Lys-Pro-Val is still unknown.…”

The oligopeptide transporter hPepT1: gateway to the innate immune response

“…Although its underlying mechanisms are not known, the ability of KPV to inhibit NF-kB activation suggests that it may act by inhibiting the synthesis of pro-inflammatory cytokines. [107][108][109][110][111][112] These peptides may therefore be good candidates for mediators of anti-inflammatory effects, by acting through PepT1 expressed in inflamed colonic epithelial and immune cells.…”